- Enantiodivergent syntheses of pantolactone and pantothenic acid from d -mannitol
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Efficient synthetic routes to both the enantiomers of pantolactone and pantothenic acid have been developed starting from d-mannitol-based d-glyceraldehyde acetonide through its conversion into a protected pantoic acid intermediate followed by either cyclization or amide bond formation with a -amino ester, and subsequent appropriate deprotection. Georg Thieme Verlag Stuttgart . New York.
- Sanyal, Ishita,Barman, Piyalideb,Banerjee, Asishkumar
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p. 1102 - 1108
(2012/05/04)
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- STIMULANT OF HAIR GROWTH BASED ON A PANTOTHENIC ACID DERIVATIVE
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Stimulant of hair growth based on a pantothenic acid derivative The invention relates to cosmetic industry and relates to application of new derivatives of pantothenic acid, namely, ammonium salts with peptides of the following formula (I) where X i s GIy, Ala , Leu , lie , VaI , Pro , Tyr , Phe , Trp , D- IIe , γ-aminobutyric acid ; Y is GIu , Z is OH, NH2, mono- or disubstituted amide (C1-C3) , alkyl ester (C1 - C3) , as well as conjugates of pantothenic acid with peptides of the following formula (II) where X is Gly, Ala , Leu, lie , VaI , Pro , Tyr , Phe , Trp ,D-Ile , γ-aminobutyric acid; Y i s Glu, Z is OH, NH2, mono- or disubstituted amide (C1-C3) , alkyl ester (C1- C3) as a hair growth stimulant, and also a method of preparation of these derivatives.
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Page/Page column 6-7
(2008/06/13)
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- AN INVESTIGATION OF THE STABILITY OF THE PHOSPHATE ESTER BOND IN D-PANTOTHENIC ACID 4'-PHOSPHATE
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The hydrolysis of the phosphate ester bond in D-pantothenic acid 4'-phosphate in strongly acid (9 and 6 N HCL), weakly acid, weakly alkaline, and strongly alkaline (5 N KOH) aqueous media has been studied.In strongly acid and strongly alkaline media the phosphate ester bond of (I) breaks down completely in 3 and 2.5 h, respectively.The rate of hydrolysis at pH values between 1.3 and 11 remains constantly low but almost doubles in the presence of lanthanum salts at pH 8-9 and in the presence of lithium salts at pH 4 and a molar ratio of (I):Me+ = 1:1.
- Moiseenok, A. G.,Slyshenkov, V. S.,Dedovich, T. V.
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p. 220 - 223
(2007/10/02)
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