- NEW PROCESS FOR THE PREPARATION OF AMENAMEVIR
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The present invention relates to an improved process for the preparation of Amenamevir and derivatives thereof via a four component Ugi reaction.
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- Preparation method of 4-(1,2,4-oxadiazole-3-yl)aniline
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The invention provides a preparation method of 4-(1,2,4-oxadiazole-3-yl)aniline. The preparation method comprises the following steps of adding 3-(4-nitrophenyl)-1,2,4-oxadiazole and an alkaline reagent into an organic solvent, slowly adding trichlorosila
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Paragraph 0040; 0041; 0046; 0048; 0052; 0055; 0057; 0060
(2018/09/21)
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- THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE
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Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.
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- NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
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The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
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Page/Page column 20
(2009/10/01)
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- NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
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The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
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Page/Page column 54
(2009/10/01)
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- HYDRAZONE DERIVATIVE
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A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof
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Page/Page column 27
(2010/11/08)
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- Antiparasitic Agents. 6. Synthesis and Anthelmintic Activities of Novel Isothiocyanatophenyl-1,2,4-oxadiazoles
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The syntheses and anthelmintic activities of 31 3- and 5-(isothiocyanatophenyl)-1,2,4-oxadiazoles are reported.In the primary anthelmintic screen, 3-(4-isothiocyanatophenyl)-1,2,4-oxadiazole (39) showed 100percent nematocidal activity and 3-(2-furanyl)-5-
- Haugwitz, R. D.,Martinez, A. J.,Venslavsky, J.,Angel, R. G.,Maurer, B. V.,et al.
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p. 1234 - 1241
(2007/10/02)
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- [(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters
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Compounds of the formula STR1 and their acid-addition salts wherein X is O or S; R is hydrogen, lower alkyl, phenyl, chloro, bromo, trifluoromethyl, lower alkoxy, phenoxy, or di(lower alkyl)amino; R1 is hydrogen, lower alkyl, phenyl, substitute
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