59908-70-2

Basic information

• Product Name: 4-(1,2,4-oxadiazol-3-yl)Benzenamine
• Synonyms: 4-(1,2,4-oxadiazol-3-yl)Benzenamine;4-(1,2,4-OXADIAZOL-3-YL)ANILINE(WXG02413)
• CAS NO: 59908-70-2
• Molecular Formula: C₈H₇N₃O
• Molecular Weight: 161.16068
• Mol File: 59908-70-2.mol

Chemical Properties

• Boiling Point: 336.1±44.0 °C(Predicted)
• Appearance: /
• Density: 1.276±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.98±0.10(Predicted)
• CAS DataBase Reference: 4-(1,2,4-oxadiazol-3-yl)Benzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,2,4-oxadiazol-3-yl)Benzenamine(59908-70-2)
• EPA Substance Registry System: 4-(1,2,4-oxadiazol-3-yl)Benzenamine(59908-70-2)

Safety Data

• Hazardous Substances Data: 59908-70-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
4-(1,2,4-oxadiazol-3-yl)Benzenamine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with diverse therapeutic profiles. Its unique structure allows for the modulation of pharmacokinetic and pharmacodynamic properties, enhancing drug efficacy and safety.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4-(1,2,4-oxadiazol-3-yl)Benzenamine is utilized as a precursor in the creation of novel agrochemicals, potentially leading to more effective and safer pesticides and other agricultural chemicals.
Used in Organic Synthesis:
4-(1,2,4-oxadiazol-3-yl)Benzenamine is employed as a versatile building block in organic synthesis, enabling the construction of complex heterocyclic compounds with potential applications in various chemical and material sciences.

Upstream product

• 16013-14-2 3-(4-nitrophenyl)-[1,2,4]oxadiazole 
• 619-72-7 4-nitrobenzonitrile 
• 1613-86-1 N-hydroxy-4-nitrobenzamidine 

Downstream Products

• 96898-49-6 (4-[1,2,4]Oxadiazol-3-yl-phenyl)-[1-(1H-pyrrol-2-yl)-meth-(E)-ylidene]-amine 
• 96898-46-3 3-<4-<<(4-chlorophenyl)methylene>amino>phenyl>-1,2,4-oxadiazole 
• 59908-71-3 <4-(1,2,4-oxadiazol-3-yl)phenyl>carbamic acid methyl ester 
• 59908-72-4 [4-(1,2,4-Oxadiazol-3-yl)phenyl]carbamic acid, phenyl ester 
• 96898-47-4 [1-(4-Chloro-3-nitro-phenyl)-meth-(E)-ylidene]-(4-[1,2,4]oxadiazol-3-yl-phenyl)-amine 
• 1187889-68-4 N-(4-[1, 2, 4]oxadiazol-3-yl-phenyl)-3-oxo-3-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-propionamide 
• 1187889-78-6 N-(4-[1,2,4]oxadiazol-3-yl-phenyl)-3-oxo-3-[4-(3,4,5-trifluoro-benzoyl)-piperazin-1-yl]-propionamide 
• 1187889-81-1 3-[4-(2-bromo-benzoyl)-piperazin-1-yl]-N-(4-[1,2,4]oxadiazol-3-yl-phenyl)-3-oxo-propionamide 
• 841301-32-4 N-(2-((4-(1,2,4-oxadiazol-3-yl)phenyl)amino)-2-oxoethyl)-N-(2,6-dimethylphenyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide 
• 1188372-71-5 3-[4-(2-chloro-phenoxy)-piperidin-1-yl]-N-(4-[1,2,4]oxadiazol-3-yl-phenyl)-3-oxo-propionamide 
• 54608-86-5 5-(4-isothicyanatophenyl)-1,2,4-oxadiazole 
• 59908-73-5 (4-[1,2,4]oxadiazol-3-yl-phenyl)-carbamic acid 2,2,2-trichloro-ethyl ester 
• 96898-48-5 [1-(5-Nitro-furan-2-yl)-meth-(E)-ylidene]-(4-[1,2,4]oxadiazol-3-yl-phenyl)-amine 

Relevant articles and documents

NEW PROCESS FOR THE PREPARATION OF AMENAMEVIR

The present invention relates to an improved process for the preparation of Amenamevir and derivatives thereof via a four component Ugi reaction.

Preparation method of 4-(1,2,4-oxadiazole-3-yl)aniline

The invention provides a preparation method of 4-(1,2,4-oxadiazole-3-yl)aniline. The preparation method comprises the following steps of adding 3-(4-nitrophenyl)-1,2,4-oxadiazole and an alkaline reagent into an organic solvent, slowly adding trichlorosila

THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

HYDRAZONE DERIVATIVE

A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof

Antiparasitic Agents. 6. Synthesis and Anthelmintic Activities of Novel Isothiocyanatophenyl-1,2,4-oxadiazoles

The syntheses and anthelmintic activities of 31 3- and 5-(isothiocyanatophenyl)-1,2,4-oxadiazoles are reported.In the primary anthelmintic screen, 3-(4-isothiocyanatophenyl)-1,2,4-oxadiazole (39) showed 100percent nematocidal activity and 3-(2-furanyl)-5-

[(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters

Compounds of the formula STR1 and their acid-addition salts wherein X is O or S; R is hydrogen, lower alkyl, phenyl, chloro, bromo, trifluoromethyl, lower alkoxy, phenoxy, or di(lower alkyl)amino; R1 is hydrogen, lower alkyl, phenyl, substitute