- The isolation and synthesis of a novel benzofuran compound from Tephrosia purpurea, and the synthesis of several related derivatives, which suppress histamine H1 receptor gene expression
-
A novel naturally occurring compound with a benzofuran skeleton was isolated from a plant, Tephrosia purpurea collected in Bangladesh. The chemical synthesis of this compound confirmed its structure, and preliminary biological results showed its suppressi
- Shill, Manik Chandra,Das, Asish Kumar,Itou, Tomohiro,Karmakar, Sanmoy,Mukherjee, Pulok K.,Mizuguchi, Hiroyuki,Kashiwada, Yoshiki,Fukui, Hiroyuki,Nemoto, Hisao
-
-
Read Online
- First asymmetric total synthesis?of Millpuline B ?
-
Millpuline B (1), isolated from Millettia pulchra, is a naturally occurring bioactive compound with a chiral center. Herein, we report the first total syntheses of both (+/-)-Millpuline B from commercal available 6,7-dihydro-4(5H)-benzofuranone (4) using Grignard reaction and asymmetric CBS reduction as the key steps. Millpuline B (1) was synthesized with up to 94.3% enantiomeric excess and the Mosher’s methods were used to elucidate the absolute configuration of key intermediates 11 and 12. All of the synthetic steps could be carried out on gram-scale.
- Dong, Hongbo,Wu, Min,Du, Weihong,Shong, Mingwei,He, Yujiao,Wang, Yuchi
-
supporting information
p. 79 - 84
(2021/11/20)
-
- CONDENSED-CYCLIC COMPOUND
-
The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.
- -
-
Paragraph 0361
(2021/08/05)
-
- HETEROCYCLIC COMPOUND
-
The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the specifi
- -
-
Paragraph 0277; 0280
(2021/08/05)
-
- 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME
-
A compound represented by the formula: wherein R1 represents a hydrogen atom, a halogen atom, alkyl group, etc., ???R2 represents a hydrogen atom, a halogen atom, alkyl group, etc., ???R3, R4, R5, R6 and R7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitute-able cycloalkyl group, etc., or adjacent two of R3, R4, R5, R6 and R7 may together with the carbon atoms to which the respective substituents are bonded form a ring which may be substituted, ???m and n each independently represent 0 or 1, a salt thereof or an ester derivative thereof; an agricultural chemical containing the same as an active ingredient; and a herbicidal composition containing the compound and a second herbicidally active compound as active ingredients.
- -
-
-
- Efficient synthesis of dihydrofurans with sulfide groups by ceric(IV) ammonium nitrate-mediated oxidative cycloaddition of 1,3-dicarbonyl compounds to vinyl sulfides. Application to the synthesis of benzo[b]naphtho[2,3-d]furan-6,11-dione and first total synthesis of millettocalyxins C and pongamol methyl ether
-
Ceric(IV) ammonium nitrate-mediated oxidative cycloaddition of 1,3-dicarbonyls to vinyl sulfides afforded substituted dihydrofurans with sulfide groups in moderate yields. This new synthetic method has been applied to the synthesis of benzo[b]naphtho[2,3-d]furan-6,11-dione and furanoflavone natural products such as millettocalyxins C and pongol methyl ether.
- Lee, Yong Rok,Kang, Keon Yong,Lee, Gun Joon,Lee, Won Kyong
-
p. 1977 - 1988
(2007/10/03)
-
- A NEW ROUTE FOR THE SYNTHESIS OF FURANOFLAVONE AND FURANOCHALCONE NATURAL PRODUCTS
-
An efficient synthesis of furanoflavones and furanochalcones has been carried out starting from a dihydrobenzofuran derivative.Key Words: Total synthesis, lanceolatin B, pongaglabrone, isopongaglabol, isopongaglabol methyl ether, pongol, pongamol, ovalite
- Lee, Yong Rok,Morehead, Andrew T.
-
p. 4909 - 4922
(2007/10/02)
-
- Dipolar Cycloaddition of Rhodium Carbenoids with Vinyl Esters. Total Synthesis of Pongamol and Lanceolatin B.
-
A new method for dipolar cycloaddition of diazocyclohexane-1,3-diones, leading to benzofuran derivatives, has been applied to the total synthesis of natural products from Tephrosia and Pongamia.
- Pirrung, Michael C.,Lee, Yong Rok
-
p. 6231 - 6234
(2007/10/02)
-