60077-57-8

Upstream product

• 186581-53-3 diazomethane 
• 487-56-9 karanjic acid 
• 67-56-1 methanol 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 164531-75-3 4-oxo-4,5,6,7-tetrahydrobenzofuran-5-carboxylic acid methyl ester 
• 84-58-2 2,3-dicyano-5,6-dichloro-p-benzoquinone 
• 480-97-7 4-hydroxybenzofuran 

Downstream Products

• 482-00-8 lanceolatin B 
• 121324-08-1 (2Z)-3-hydroxy-1-(4–methoxy-1-benzofuran-5-yl)-3-phenylprop 2-en-1-one 

Relevant academic research and scientific papers

The isolation and synthesis of a novel benzofuran compound from Tephrosia purpurea, and the synthesis of several related derivatives, which suppress histamine H1 receptor gene expression

A novel naturally occurring compound with a benzofuran skeleton was isolated from a plant, Tephrosia purpurea collected in Bangladesh. The chemical synthesis of this compound confirmed its structure, and preliminary biological results showed its suppressi

First asymmetric total synthesis?of Millpuline B ?

Millpuline B (1), isolated from Millettia pulchra, is a naturally occurring bioactive compound with a chiral center. Herein, we report the first total syntheses of both (+/-)-Millpuline B from commercal available 6,7-dihydro-4(5H)-benzofuranone (4) using Grignard reaction and asymmetric CBS reduction as the key steps. Millpuline B (1) was synthesized with up to 94.3% enantiomeric excess and the Mosher’s methods were used to elucidate the absolute configuration of key intermediates 11 and 12. All of the synthetic steps could be carried out on gram-scale.

CONDENSED-CYCLIC COMPOUND

The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

HETEROCYCLIC COMPOUND

The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the specifi

3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME

A compound represented by the formula: wherein R1 represents a hydrogen atom, a halogen atom, alkyl group, etc., ???R2 represents a hydrogen atom, a halogen atom, alkyl group, etc., ???R3, R4, R5, R6 and R7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitute-able cycloalkyl group, etc., or adjacent two of R3, R4, R5, R6 and R7 may together with the carbon atoms to which the respective substituents are bonded form a ring which may be substituted, ???m and n each independently represent 0 or 1, a salt thereof or an ester derivative thereof; an agricultural chemical containing the same as an active ingredient; and a herbicidal composition containing the compound and a second herbicidally active compound as active ingredients.

Efficient synthesis of dihydrofurans with sulfide groups by ceric(IV) ammonium nitrate-mediated oxidative cycloaddition of 1,3-dicarbonyl compounds to vinyl sulfides. Application to the synthesis of benzo[b]naphtho[2,3-d]furan-6,11-dione and first total synthesis of millettocalyxins C and pongamol methyl ether

Ceric(IV) ammonium nitrate-mediated oxidative cycloaddition of 1,3-dicarbonyls to vinyl sulfides afforded substituted dihydrofurans with sulfide groups in moderate yields. This new synthetic method has been applied to the synthesis of benzo[b]naphtho[2,3-d]furan-6,11-dione and furanoflavone natural products such as millettocalyxins C and pongol methyl ether.

A NEW ROUTE FOR THE SYNTHESIS OF FURANOFLAVONE AND FURANOCHALCONE NATURAL PRODUCTS

An efficient synthesis of furanoflavones and furanochalcones has been carried out starting from a dihydrobenzofuran derivative.Key Words: Total synthesis, lanceolatin B, pongaglabrone, isopongaglabol, isopongaglabol methyl ether, pongol, pongamol, ovalite

Dipolar Cycloaddition of Rhodium Carbenoids with Vinyl Esters. Total Synthesis of Pongamol and Lanceolatin B.

A new method for dipolar cycloaddition of diazocyclohexane-1,3-diones, leading to benzofuran derivatives, has been applied to the total synthesis of natural products from Tephrosia and Pongamia.