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ANB-NOS, also known as ANB-NOS Crosslinker, is a photoactive, heterobifunctional cross-linking reagent that contains a nitrophenyl azide group and an amine reactive NHS ester group. It is capable of reacting with nucleophiles and is typically used for coupling via ester to primary amine by amide bond formation in the pH range of 6.5-8.5. The second bonding occurs during UV irradiation (250-350 nm) via reactive nitrene, which is rapid and non-specific.

60117-35-3

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60117-35-3 Usage

Uses

Used in Ophthalmology:
ANB-NOS is used as a crosslinking agent for devices implanted in the eyes to treat glaucoma and/or dry eye. Its photoactive properties and ability to form amide bonds make it suitable for this application, providing a stable and effective treatment option for patients.
Used in Bioconjugation and Molecular Biology:
ANB-NOS is used as a heterobifunctional crosslinking reagent in bioconjugation and molecular biology applications. Its dual reactive groups allow for the specific coupling of molecules, such as proteins or other biomolecules, through the formation of amide bonds. This makes it a valuable tool for researchers working with biomolecular interactions and the development of new therapeutic agents.
Used in Material Science:
In the field of material science, ANB-NOS can be used as a crosslinking agent to improve the properties of various materials. Its ability to form stable amide bonds and undergo rapid, non-specific bonding upon UV irradiation makes it a versatile component in the development of new materials with enhanced mechanical, chemical, or biological properties.

Check Digit Verification of cas no

The CAS Registry Mumber 60117-35-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,1,1 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60117-35:
(7*6)+(6*0)+(5*1)+(4*1)+(3*7)+(2*3)+(1*5)=83
83 % 10 = 3
So 60117-35-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H7N5O6/c12-14-13-6-1-2-8(16(20)21)7(5-6)11(19)22-15-9(17)3-4-10(15)18/h1-2,5H,3-4H2

60117-35-3 Well-known Company Product Price

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  • TCI America

  • (S0860)  N-Succinimidyl 5-Azido-2-nitrobenzoate  >97.0%(HPLC)

  • 60117-35-3

  • 10mg

  • 690.00CNY

  • Detail

60117-35-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Azido-2-nitrobenzoic acid N-hydroxysuccinimide ester

1.2 Other means of identification

Product number -
Other names (2,5-dioxopyrrolidin-1-yl) 5-azido-2-nitrobenzoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60117-35-3 SDS

60117-35-3Relevant articles and documents

First synthesis of N-acylated photoactivatable analogues of glutathione bearing an aryl azide moiety

Bernardi, Dan,Ba, Lalla Aicha,Kirsch, Gilbert

, p. 140 - 144 (2008/01/03)

N-Acylated photoactivatable analogues of glutathione bearing an aryl azide moiety were synthesized for the first time starting from S-tritylglutathione. Georg Thieme Verlag Stuttgart.

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