- Baimantuoluosides A-C, three new withanolide glucosides from the flower of Datura metel L.
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In search for bioactive compounds from the flower of Datura metel L., three new withanolide glucosides, namely baimantuoluosides A, B, and C (1-3, resp.) were isolated. Enzymatic hydrolysis of 1-3 afforded the corresponding aglycones 1a, 2a, and 3a, respectively. The structures of the new compounds were elucidated as (5α,6α,7α,12β,22R)-5,12-dihydroxy-1,26- dioxo-6,7:22,26-diepoxyergosta-2,24-dien-27-yl β-D-glucopyranoside (1), (5α,6α,7α,12α,22R)-5,12-dihydroxy-1,26-dioxo-6,7:22, 26-diepoxyergosta-2,24-dien-27-yl β-D-glucopyranoside (2), (5α,6α,7α,22R)-5-hydroxy-1,26-dioxo-6,7:22, 26-diepoxyergosta-2,24-dien-27-yl β-D-glucopyranoside (3) on the basis of chemical and physicochemical evidence, and are further confirmed by the structure determination by X-ray diffraction of withanolide aglycone 1a.
- Kuang, Haixue,Yang, Bingyou,Tang, Ling,Xia, Yonggang,Dou, Deqiang
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experimental part
p. 1315 - 1323
(2009/10/17)
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