60132-35-6

Basic information

• Product Name: Pterodondiol
• Synonyms: Pterodondiol
• CAS NO: 60132-35-6
• Molecular Formula: C₁₅H₂₈O₂
• Molecular Weight: 180
• Mol File: 60132-35-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pterodondiol(CAS DataBase Reference)
• NIST Chemistry Reference: Pterodondiol(60132-35-6)
• EPA Substance Registry System: Pterodondiol(60132-35-6)

Safety Data

• Hazardous Substances Data: 60132-35-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pterodondiol is used as an anti-inflammatory and analgesic agent for its ability to alleviate pain and reduce inflammation, making it a potential treatment for various pain and inflammation-related conditions.
Used in Oncology Research:
Pterodondiol is used as a potential anti-cancer agent in preclinical studies, where it has shown promise in targeting and inhibiting cancer cell growth, thus contributing to the development of novel cancer therapeutics.
Used in Drug Development:
Pterodondiol is utilized in the ongoing research and development of new therapeutic agents due to its diverse pharmacological properties, which include anti-inflammatory, analgesic, and potential anti-cancer effects. This makes it a valuable compound for creating innovative treatments in the pharmaceutical industry.

Upstream product

• 198994-52-4 Methanesulfonic acid (1R,2S,4aR,7R,8aS)-1-hydroxy-7-(1-hydroxy-1-methyl-ethyl)-1,4a-dimethyl-decahydro-naphthalen-2-yl ester 
• 198994-37-5 Methanesulfonic acid (1R,2S,4aR,7R,8aR)-7-isopropenyl-1,4a-dimethyl-decahydro-naphthalen-2-yl ester 
• 198994-38-6 (1R,2R,4aR,7R,8aR)-1,4a-dimethyl-7-(prop-1-en-2-yl)-decahydronaphthalen-2-yl methanesulfonate 
• 198994-44-4 ent-7βH-4α,14-epoxyeudesm-11-en-3α-ol 
• 198994-42-2 (2S,4aR,7R,8aS)-7-Isopropenyl-4a-methyl-1-methylene-decahydro-naphthalen-2-ol 
• 198994-35-3 (1R,2R,4aR,7R,8aR)-1,4a-dimethyl-7-(prop-1-en-2-yl)-decahydronaphthalen-2-ol 
• 198994-50-2 (1R,2S,4aR,7R,8aS)-7-(1-Hydroxy-1-methyl-ethyl)-1,4a-dimethyl-decahydro-naphthalene-1,2-diol 
• 21683-08-9 (1R,4aR,7R,8aR)-8a-hydroxy-1,4a-dimethyl-7-(prop-1-en-2-yl)-octahydronaphthalen-2(1H)-one 
• 2303-31-3 7-epi-cyperone 
• 60209-18-9 4-Epi-5-epi-10-epieudesm-11-en-3β-ol 
• 28290-27-9 (1R,4aR,7R,8aR)-7-Isopropenyl-1,4a-dimethyl-octahydro-naphthalen-2-one 
• 5524-05-0 (2R,5R)-5-isopropenyl-2-methylcyclohexanone 
• 1629-58-9 4-penten-3-one 
• 199173-84-7 (1aS,3aR,6R,7aS,7bR)-6-Isopropenyl-3a,7b-dimethyl-decahydro-1-oxa-cyclopropa[a]naphthalene 

Downstream Products

• 6168-59-8 intermedeol 

Relevant articles and documents

Short and efficient hemisynthesis of α-eudesmol and cryptomeridiol

The aerial part of Dittrichia viscosa yielded two sesquiterpenes, isocostic acid (1) and ilicic acid (2), on multigram scale. These acids are appropriate starting materials for short and facile syntheses of α-eudesmol (5) and cryptomeridiol (6), natural products featuring anti-Alzheimer and anti-spasmodic properties. Compounds 5 and 6 were obtained in three steps in overall yields of 70% and 52%, respectively.

Enantioselective total syntheses of (-)-7βH-eudesmane-4α,11-diol and (+)-ent-7βH-eudesmane-4α,11-diol

The syntheses of (-)-7βH-eudesmane-4α,11-diol (2) and (+)-ent-7βH- eudesmane-4α,11-diol (ent2) were carried out starting from (-)- and (+)- dihydrocarvones. As a result, the structure, including absolute configuration, of the naturally occurring eudesmane-4,11-diol isolated from Pluchea arguta was determined to be (+)-ent-7βH-eudesmane-4α,11-diol (ent- 2).

Structures and spasmolytic activities of derivatives from sesquiterpenes of Alpinia speciosa and Alpinia japonica

Sesquiterpenes isolated from Alpinia speciosa and Alpinia japonica, and their derivatives were found to inhibit histamine- or barium chloride- induced contraction of excised guinea pig ileum when tested by the Magnus method. Major spasmolytic principles contained in those extracts were the sesquiterpenes, β-eudesmol, nerolidol, humulene epoxide II and 4α- hydroxydihydroagarofuran. Relationships between the chemical structures of the sesquiterpenes and their derivatives, and their spasmolytic activities were discussed.

SESQUITERPENES FROM LEAVES OF CRYPTOMERIA JAPONICA

Twenty-seven sesquiterpenes were isolated from leaves of Cryptomeria japonica.The new compounds included elem-1-en-4,11-diol, 11-acetoxyeudesman-4α-ol, eudesmane-5α,11-diol, 3-eudesmene-1β,11-diol, 1β-acetoxy-3-eudesmen-11-ol, 4-eudesmene-1β,11-diol, 1β-acetoxy-4-eudesmen-11-ol, 7-epi-4-eudesmene-1β,11-diol, 1β-acetoxy-4(15)eudesmen-11-ol.Their structures were determined by chemical and spectral methods. - Key words: Cryptomeria japonica; Taxodiaceae; leaves; sesquiterpenes.

Biotransformation of (+/-)-4,8-dimethylcyclodeca-3(E),7(E)-dien-1β-ol and (+)-Hedycaryol by Cichorium intybus

The biotransformation of the synthetic (E,E)-1,5-cyclodecadienol 5 and (+)-hedycaryol (11) by a root suspension of fresh chicory has been investigated.Incubation of 5 with a root suspension gave a 2:1 mixture of epimeric eudesmanediols 7a and 7b whereas 11 was selectively converted into cryptomeridiol (12).An explanation for the obtained results is proposed.

Structures of Eudesmagnolol and Eudeshonokiol, Novel Sesquiterpene-Neolignans Isolated from Magnolia obovata

Eudesmagnolol and eudeshonokiol, isolated from the bark of Magnolia obovata, have been assigned to unprecedented structures linked via an ether bond between sesquiterpene, eudesmol, and neolignans, magnolol and honokiol, respectively.

NOVEL NEUROTROPHIC SESQUITERPENE-NEOLIGNANS FROM MAGNOLIA OBOVATA

Novel sesquiterpene-neolignans, eudesobovatols A (1) and B (2) isolated from Magnolia obovata have been assigned structures on the basis of detailed spectroscopic analyses and chemical degradation, and eudesobovatol A has been found to exhibit neurotrophic activity at 1E-5 M 1E-7 M on neuronal cell culture system of fetal rat cerebral hemisphere.