- A Scalable Metal-, Azide-, and Halogen-Free Method for the Preparation of Triazoles
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A scalable metal-, azide-, and halogen-free method for the synthesis of substituted 1,2,3-triazoles has been developed. The reaction proceeds through a 3-component coupling of α-ketoacetals, tosyl hydrazide, and a primary amine. The reaction shows outstanding functional-group tolerance with respect to both the α-ketoacetal and amine coupling partners, providing access to 4-, 1,4-, 1,5-, and 1,4,5-substituted triazoles in excellent yield. This robust method results in densely functionalised 1,2,3-triazoles that remain challenging to prepare by azide–alkyne cycloaddition (AAC, CuAAC, RuAAC) methods and can be scaled in either batch or flow reactors. Methods for the chemoselective reaction of either aliphatic amines or anilines are also described, revealing some of the potential of this novel and highly versatile transformation.
- Clark, Peter R.,Hayes, Jerome F.,Tomkinson, Nicholas C. O.,Williams, Glynn D.
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supporting information
p. 6740 - 6744
(2020/03/23)
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- CYCLOADDITION DES METHYLAZIDE ET PHENYLAZIDE AU β-NITROSTYRENE ET AU NITROPROPENE HOMOLOGUE
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Phenylazide and methylazide reacts with title olefines and gives two isomeric triazoles without nitro group, and 4-nitro-1,2,3 triazole.The isomerisation of starting alkenes explains the formation of isomeric triazoles.Oxydation of amino-nitro-diazocompounds in equilibrium with 1,2,3 triazolines leads to 4-nitro-1,2,3 triazoles.
- Cailleux, P.,Piet, J. C.,Benhaoua, H.,Carrie, R.
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