60166-43-0

Basic information

• Product Name: 1,4-diMethyl-1H-1,2,3-triazole
• Synonyms: 1,4-diMethyl-1H-1,2,3-triazole;EOS-61404
• CAS NO: 60166-43-0
• Molecular Formula: C₄H₇N₃
• Molecular Weight: 97.11848
• EINECS: -0
• Mol File: 60166-43-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 315 °C (decomp)
• Boiling Point: 173.7±33.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.79±0.10(Predicted)
• CAS DataBase Reference: 1,4-diMethyl-1H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-diMethyl-1H-1,2,3-triazole(60166-43-0)
• EPA Substance Registry System: 1,4-diMethyl-1H-1,2,3-triazole(60166-43-0)

Safety Data

• Hazardous Substances Data: 60166-43-0(Hazardous Substances Data)

Usage

General Description

1,4-DiMethyl-1H-1,2,3-triazole, also known as CAS Number 6278-40-8, bears the molecular formula of C4H8N3, and is soluble in water. This chemical compound falls under the chemical class of triazoles which are known for their function as a protective agent in plants and vital component in pharmaceutical drugs. 1,4-DiMethyl-1H-1,2,3-triazole can be characterized by its aromaticity, hydrogen bond acceptor, and properties as an alkyl halide. While specific uses for the compound are not widely listed, triazoles in general have a variety of uses across different industries such as in making fungicides, herbicides, as corrosion inhibitors, and medications, particularly antifungal drugs. Overall, caution must be practiced when handling this compound, due to its potential volatile nature and health risks associated.

Upstream product

• 56020-04-3 N'-(1,1-dimethoxypropan-2-ylidene)-4-methylbenzenesulfonohydrazide 
• 74-89-5 methylamine 
• 91257-99-7 N′-(2,2-dichloro-1-methylethylidene)-4-methylbenzenesulfonohydrazide 
• 624-90-8 methyl azide 
• 27675-36-1 1-nitropropene 

Downstream Products

• 1047637-17-1 1,4-dimethyl-5-(tri-n-butylstannyl)-1H-1,2,3-triazole 
• 1616291-01-0 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

A Scalable Metal-, Azide-, and Halogen-Free Method for the Preparation of Triazoles

A scalable metal-, azide-, and halogen-free method for the synthesis of substituted 1,2,3-triazoles has been developed. The reaction proceeds through a 3-component coupling of α-ketoacetals, tosyl hydrazide, and a primary amine. The reaction shows outstanding functional-group tolerance with respect to both the α-ketoacetal and amine coupling partners, providing access to 4-, 1,4-, 1,5-, and 1,4,5-substituted triazoles in excellent yield. This robust method results in densely functionalised 1,2,3-triazoles that remain challenging to prepare by azide–alkyne cycloaddition (AAC, CuAAC, RuAAC) methods and can be scaled in either batch or flow reactors. Methods for the chemoselective reaction of either aliphatic amines or anilines are also described, revealing some of the potential of this novel and highly versatile transformation.

CYCLOADDITION DES METHYLAZIDE ET PHENYLAZIDE AU β-NITROSTYRENE ET AU NITROPROPENE HOMOLOGUE

Phenylazide and methylazide reacts with title olefines and gives two isomeric triazoles without nitro group, and 4-nitro-1,2,3 triazole.The isomerisation of starting alkenes explains the formation of isomeric triazoles.Oxydation of amino-nitro-diazocompounds in equilibrium with 1,2,3 triazolines leads to 4-nitro-1,2,3 triazoles.