60197-60-6

Basic information

• Product Name: LICOFLAVONOL
• Synonyms: LICOFLAVONOL;3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
• CAS NO: 60197-60-6
• Molecular Formula: C₂₀H₁₈O₆
• Molecular Weight: 354.35
• Mol File: 60197-60-6.mol

Chemical Properties

• Boiling Point: 608.3°C at 760 mmHg
• Flash Point: 220.2°C
• Appearance: /
• Density: 1.444g/cm³
• Vapor Pressure: 2.16E-15mmHg at 25°C
• Refractive Index: 1.699
• PKA: 6.86±0.40(Predicted)
• CAS DataBase Reference: LICOFLAVONOL(CAS DataBase Reference)
• NIST Chemistry Reference: LICOFLAVONOL(60197-60-6)
• EPA Substance Registry System: LICOFLAVONOL(60197-60-6)

Safety Data

• Hazardous Substances Data: 60197-60-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
LICOFLAVONOL is used as an antioxidant agent for its ability to scavenge free radicals, which can help protect cells from oxidative damage and reduce the risk of various diseases.
LICOFLAVONOL is used as an anti-inflammatory agent for its capacity to inhibit the production of inflammatory mediators, which can help alleviate inflammation and associated symptoms.
LICOFLAVONOL is used as an anti-cancer agent for its potential to induce apoptosis in cancer cells, which can contribute to the suppression of tumor growth and progression.
Used in Neuroprotective Applications:
LICOFLAVONOL is used as a neuroprotective agent for its potential to protect neurons from damage and degeneration, which can be beneficial in the treatment of neurodegenerative diseases.
Used in Immunomodulation:
LICOFLAVONOL is used as an immunomodulatory agent for its ability to modulate immune responses, which can be useful in managing autoimmune and inflammatory conditions.

InChI:InChI=1/C20H18O6/c1-10(2)3-8-13-14(22)9-15-16(17(13)23)18(24)19(25)20(26-15)11-4-6-12(21)7-5-11/h3-7,9,21-23,25H,8H2,1-2H3

Upstream product

• 143724-72-5 5-Hydroxy-3,7-bis-methoxymethoxy-2-(4-methoxymethoxy-phenyl)-6-(3-methyl-but-2-enyl)-chromen-4-one 
• 520-18-3 kaempferol 
• 870-63-3 prenyl bromide 
• 143724-66-7 3,4',7-tris-O-methoxymethylkaempferol 

Downstream Products

• 143724-80-5 3,5-Dihydroxy-2-(4-hydroxy-phenyl)-8,8-dimethyl-7,8-dihydro-6H-pyrano[3,2-g]chromen-4-one 

Relevant articles and documents

Icarisid I type compound, derivatives, pharmaceutical composition and application thereof

The invention provides an icarisid I type compound and derivatives, or a stereisomer, geometrical isomer, tautomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically-acceptable salt or prodrug of the compound of formula I (shown in the specification). The synthetic materials of the icarisid I type compound and derivatives are selected from quercetin, apigenin, kaempferol, scutellarein, wild scutellarein, chrysin, daidzein, genistein, isorhamnetin, myricetin, luteolin, fisetin or icaritin. By methods of chemical synthesis and bioengineering, the icarisid I type compound and derivatives with better biological effect and higher economic benefit can be synthesized by flavone compounds (such as the apigenin and the quercetin and the like) with higher existence in nature.

1H-NMR CHEMICAL SHIFT OF THE FLAVONOL 5-HYDROXY PROTON AS A CHARACTERIZATION OF 6- OR 8-ISOPRENOID SUBSTITUTION

1H Nmr examination of 6- or 8-isoprenoid substituted flavonols has shown that the location of isoprenoid side chain on A ring can be deduced from the chemical shift of the 5-hydroxy proton.The application of this 1H nmr technique to identification of the