Welcome to LookChem.com Sign In|Join Free

CAS

  • or

520-18-3

Post Buying Request

520-18-3 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

520-18-3 Usage

Pharmacological effects

Kaempferol (3,5,7‐trihydroxy‐2‐[4‐hydroxyphenyl]‐4H‐1‐benzopyran‐4‐one) is a yellow bioactive flavonoid, which is present inmany edible plants such as tea, cabbage, broccoli, endive, kale, beans, tomato, strawberries, leek, and grapes. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Its efficacy, a broad range of activity, and low toxicity compared with other examined compounds, make it an attractive chemical in the fight against diseases (including cancer).

Mechanism of action

Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3‐kinase (PI3K)/AKT (protein kinase B) and human T‐cell leukemia/lymphoma virus‐I (HTLV-I) signaling pathways, suppresses protein expression of epithelial‐mesenchymal transition (EMT)‐related markers including N‐cadherin, E‐cadherin, Slug, and Snail, and metastasis‐related markers such as matrix metallopeptidase 2 (MMP-2).

Bioactivity

As an anti‐oxidant, kaempferol counteracts production of superoxide ions and lowers the formation of reactive oxygen and nitrogen species. It also scavenges Fenton‐generated hydroxyl radical, peroxynitrite, and hydroxyl radicals. Furthermore, kaempferol suppresses the activity of xanthine oxidase and enhances the activities of catalase, heme oxygenase‐1, and superoxide dismutase.

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 520-18-3 differently. You can refer to the following data:
1. antidepressant, inhibits fatty acid amide hydrolase
2. Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.
3. Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.

General Description

Kaempferol is a polyphenolic antioxidant abundantly present in vegetables and fruits. It has a diphenylpropane structure. In many plants, it is present as a glycosidic form namely, kaempferol-3-O-glucoside.

Biological Activity

Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca 2+ uniporter (EC 50 = 7 μ M). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro .

Biochem/physiol Actions

Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.

Anticancer Research

Kaempferol is one of the secondary metabolites found in some plants, plant-derivedfoods, and traditional medicines. It is a flavonoid compound obtained from someedible plants including grapes, tea, strawberries, broccoli, tomato, cabbage, leek,kale, endive, and beans. It inhibits growth and migration of pancreatic cancer cellsby acting on proto-oncogene tyrosine kinase (Src), ERK1/2, and AKT pathways(Singh et al. 2016a). It is being investigated in pancreatic and lung cancers toevaluate its antiangiogenic, anticancer, and radical scavenging activities. It showsmoderate cytostatic activity in PC3, HeLa, and K562 human cancer cells. It isidentified as aryl hydrocarbon receptor antagonist and acts against ABCG2 (ATP-bindingcassette subfamily G member 2)-mediated multidrug resistance bypreventing the ABCG2 upregulation in esophageal carcinoma. It induces theapoptosis of ovarian cancer cell by activating p53 in intrinsic pathway mechanism.It is an inhibitor of breast cancer resistance protein (BCRP), quinine reductase-2,and a substrate of BCRP (Calderon-Montano et al. 2011; Wang et al. 2012).

Check Digit Verification of cas no

The CAS Registry Mumber 520-18-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 0 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 520-18:
(5*5)+(4*2)+(3*0)+(2*1)+(1*8)=43
43 % 10 = 3
So 520-18-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H10O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-6,16-19H

520-18-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (K0018)  Kaempferol Hydrate  >97.0%(HPLC)

  • 520-18-3

  • 100mg

  • 990.00CNY

  • Detail
  • TCI America

  • (K0018)  Kaempferol Hydrate  >97.0%(HPLC)

  • 520-18-3

  • 1g

  • 5,750.00CNY

  • Detail
  • Sigma-Aldrich

  • (96353)  Kaempferol  analytical standard

  • 520-18-3

  • 96353-10MG

  • 3,326.31CNY

  • Detail
  • USP

  • (1354900)  Kaempferol  United States Pharmacopeia (USP) Reference Standard

  • 520-18-3

  • 1354900-15MG

  • 4,750.20CNY

  • Detail
  • Sigma

  • (60010)  Kaempferol  ≥97.0% (HPLC)

  • 520-18-3

  • 60010-25MG

  • 1,033.11CNY

  • Detail
  • Sigma

  • (60010)  Kaempferol  ≥97.0% (HPLC)

  • 520-18-3

  • 60010-100MG

  • 3,463.20CNY

  • Detail
  • Sigma-Aldrich

  • (00550580)  Kaempferol  primary pharmaceutical reference standard

  • 520-18-3

  • 00550580-10MG

  • 4,346.55CNY

  • Detail

520-18-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name kaempferol

1.2 Other means of identification

Product number -
Other names 3,4',5,7-Tetrahydroxyflavone Hydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:520-18-3 SDS

520-18-3Synthetic route

kaempferol 3-O-β-D-glucuronide
22688-78-4

kaempferol 3-O-β-D-glucuronide

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogenchloride; methanol for 2h; Heating;100%
astragalin
480-10-4

astragalin

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogenchloride for 1h; Heating;91.1%
With sulfuric acid
kaempferol 5,7,4'-trimethyl ether
1098-92-6

kaempferol 5,7,4'-trimethyl ether

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With boron tribromide In dichloromethane for 24h; Heating;91%
With 1-butylpyridinium bromide for 0.1h; microwave irradiation;72%
With trimethylsilyl iodide In methanol at 35℃; for 96h; Inert atmosphere;
5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-hydroxy-4H-chromen-4-one
23405-70-1

5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-hydroxy-4H-chromen-4-one

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol under 760.051 Torr; for 12h;72%
With hydrogen; palladium(II) hydroxide In tetrahydrofuran; methanol at 20℃; for 3h;58%
dihydrokaempferol
724434-08-6

dihydrokaempferol

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With potassium pyrosulfite In ethanol at 100℃;60%
With oxygen; potassium carbonate In ethanol for 8h; Reflux;23.4 g
Conditions
ConditionsYield
With sulfuric acid; water unter Durchleiten von Luft;
With water; sodium hydrogensulfite
With FLAVONOL SYNTHASE; TrxA-His-AtFLS1 In aq. buffer at 30℃; for 3h; pH=7.2; Kinetics; Concentration; Temperature; Enzymatic reaction;
astragalin
480-10-4

astragalin

A

D-Glucose
2280-44-6

D-Glucose

B

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With emulsin
With sulfuric acid
With hydrogenchloride
Hydrolysis; Acid hydrolysis;
Conditions
ConditionsYield
Product distribution; acid hydrolysis, also mild acid hydrolysis and enzymatic hydrolysis, other flavonoid;
Conditions
ConditionsYield
acidic hydrolysis for structure determination;
3,7-Di-O-glucosylkaempferol
25615-14-9

3,7-Di-O-glucosylkaempferol

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With sulfuric acid
kaempferol 7-O-α-L-rhamnopyranoside
5041-97-4

kaempferol 7-O-α-L-rhamnopyranoside

A

L-rhamnose
73-34-7

L-rhamnose

B

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogen cation
kaempferol 3-rhamnoside
482-39-3, 22334-39-0, 28978-08-7

kaempferol 3-rhamnoside

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogenchloride; ethanol for 1h; Heating;
With naringinase In acetate buffer at 20℃; for 3h; pH=5.5; Enzymatic reaction;
With flavonol 3-O-rhamnosyltransferase UGT78D1 from arabidopsis thaliana; UDP-Rha

A

D-Galactose
10257-28-0

D-Galactose

B

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With acid hydrolysis
With sulfuric acid
With hydrogenchloride In ethanol
Kaempferol-3,7-dirhamnosid
482-38-2

Kaempferol-3,7-dirhamnosid

A

L-rhamnose
73-34-7

L-rhamnose

B

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
In methanol for 1.66667h; 2percent H2SO4;
ermanin
20869-95-8

ermanin

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
demethylation;

A

D-Glucose
2280-44-6

D-Glucose

B

p-Coumaric Acid
7400-08-0

p-Coumaric Acid

C

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogenchloride at 100℃; for 2h;

A

D-glucose
50-99-7

D-glucose

B

p-Coumaric Acid
7400-08-0

p-Coumaric Acid

C

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogenchloride In methanol for 1.5h; Product distribution; Heating; hydrolysis;
rhamnocitrin
569-92-6

rhamnocitrin

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogen iodide; acetic anhydride; phenol at 130℃; for 0.5h;
kaempferol 3-O-[β-D-glucopyranosyl-(1->2)-β-D-glucopyranoside]
152390-63-1

kaempferol 3-O-[β-D-glucopyranosyl-(1->2)-β-D-glucopyranoside]

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 0.5h;
kaempferol 3-O-β-D-<2G-O-β-D-xylopyranosyl-6G-O-α-L-rhamnopyranosyl>glucopyranoside
131573-90-5

kaempferol 3-O-β-D-<2G-O-β-D-xylopyranosyl-6G-O-α-L-rhamnopyranosyl>glucopyranoside

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 1h;
3-O-[(2-O-β-D-galactopyranosyl-6-O-α-L-rhamnopyranosyl)-β-D-glucopyranosyl]-kaempferol
135095-52-2

3-O-[(2-O-β-D-galactopyranosyl-6-O-α-L-rhamnopyranosyl)-β-D-glucopyranosyl]-kaempferol

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 1h;
Kaempferol-3-O-<3,6-di-O-acetyl-2,4-di-O-(p-cumaroyl)-β-D-glucopyranosid>
94474-72-3

Kaempferol-3-O-<3,6-di-O-acetyl-2,4-di-O-(p-cumaroyl)-β-D-glucopyranosid>

A

D-Glucose
2280-44-6

D-Glucose

B

p-Coumaric Acid
7400-08-0

p-Coumaric Acid

C

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
acid total hydrolysis;
kaempferol-5-O-arabinoside

kaempferol-5-O-arabinoside

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogenchloride
Kaempferol-3-O-<2Glc-(p-cumaroyl)-α-L-rhamnopyranosyl(1->6)-β-D-glucopyranosid>

Kaempferol-3-O-<2Glc-(p-cumaroyl)-α-L-rhamnopyranosyl(1->6)-β-D-glucopyranosid>

A

L-Rhamnose
3615-41-6

L-Rhamnose

B

D-glucose
50-99-7

D-glucose

C

p-Coumaric Acid
7400-08-0

p-Coumaric Acid

D

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogenchloride In methanol for 1.5h; Product distribution; Heating; hydrolysis;
lepidoside
89946-00-9

lepidoside

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With sulfuric acid In methanol for 0.5h; Heating;

A

D-Glucose
2280-44-6

D-Glucose

B

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
acid hydrolysis;
7-O-β-D-glucopyranosyl-kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside
78527-48-7

7-O-β-D-glucopyranosyl-kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside

A

D-Glucose
2280-44-6

D-Glucose

B

L-rhamnose
73-34-7

L-rhamnose

C

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogenchloride In methanol for 2h; Heating;
kaempferol 3-O-(3'',6''-di-O-E-p-coumaroyl)-β-D-glucopyranoside
74712-68-8

kaempferol 3-O-(3'',6''-di-O-E-p-coumaroyl)-β-D-glucopyranoside

A

D-Glucose
2280-44-6

D-Glucose

B

p-Coumaric Acid
7400-08-0

p-Coumaric Acid

C

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With hydrogenchloride at 100℃; for 3h;

A

D-Glucose
2280-44-6

D-Glucose

B

L-rhamnose
73-34-7

L-rhamnose

C

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With sulfuric acid In water for 2h; Heating;
kaempferol
520-18-3

kaempferol

acetic anhydride
108-24-7

acetic anhydride

3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one
16274-11-6

3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one

Conditions
ConditionsYield
With pyridine at 20℃; for 4h;95%
With pyridine at 20℃;94%
With pyridine94%
kaempferol
520-18-3

kaempferol

acetic anhydride
108-24-7

acetic anhydride

5,7-dihydroxy-3,3',4',6-tetramethoxyflavone
35688-42-7

5,7-dihydroxy-3,3',4',6-tetramethoxyflavone

Conditions
ConditionsYield
With pyridine at 20℃; for 4h; Inert atmosphere;95%
kaempferol
520-18-3

kaempferol

acetic anhydride
108-24-7

acetic anhydride

kaempferol triacetate
143724-69-0

kaempferol triacetate

Conditions
ConditionsYield
With pyridine at 20℃; for 0.25h; Inert atmosphere;95%
With pyridine at 20℃; for 0.25h;95%
With pyridine at 100 - 140℃;90.5%
kaempferol
520-18-3

kaempferol

acetic anhydride
108-24-7

acetic anhydride

C19H14O8

C19H14O8

Conditions
ConditionsYield
With piperidine at 100 - 140℃;92.4%
kaempferol
520-18-3

kaempferol

acetic anhydride
108-24-7

acetic anhydride

3,4',5-tri-O-acetylkaempferol

3,4',5-tri-O-acetylkaempferol

Conditions
ConditionsYield
With 4-methylpiperidin at 100 - 140℃;91.8%
kaempferol
520-18-3

kaempferol

uridine-5'-diphosphoglucose
952585-00-1

uridine-5'-diphosphoglucose

kaempferol 8-C-β-D-glucoside
562068-65-9

kaempferol 8-C-β-D-glucoside

Conditions
ConditionsYield
With TcCGT1-C-glycosyltransferase from Trolliuschinensisuridine in complex with uridine diphosphate In aq. phosphate buffer; dimethyl sulfoxide pH=8; Enzymatic reaction;91.6%
kaempferol
520-18-3

kaempferol

dimethyl sulfate
77-78-1

dimethyl sulfate

3,4',5,7-tetramethoxyflavone
16692-52-7

3,4',5,7-tetramethoxyflavone

Conditions
ConditionsYield
With potassium carbonate In acetone at 50℃; for 48h;90%
With potassium carbonate In acetone at 50℃;90%
With potassium carbonate In acetone at 50℃; for 48h;86.3%
With potassium carbonate
With potassium carbonate In acetone for 4h; Heating;
kaempferol
520-18-3

kaempferol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

3,7,4'-tri-O-tert-butyldimethylsilylkaempferol
1246814-11-8

3,7,4'-tri-O-tert-butyldimethylsilylkaempferol

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 0.25h;90%
In N,N-dimethyl-formamide at 20℃; Inert atmosphere;81%
kaempferol
520-18-3

kaempferol

benzyl bromide
100-39-0

benzyl bromide

3,4',7-tri-O-benzylkaempferol

3,4',7-tri-O-benzylkaempferol

Conditions
ConditionsYield
With potassium carbonate In acetone90%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;72%
kaempferol
520-18-3

kaempferol

1-deoxy-1-fluoro-α-D-glucose
2106-10-7

1-deoxy-1-fluoro-α-D-glucose

kaempferol 7-α-O-glucoside
16290-07-6

kaempferol 7-α-O-glucoside

Conditions
ConditionsYield
With α-glucosidase from sulfolobus solfataricus In dimethyl sulfoxide at 45℃; for 2h; pH=9; Enzymatic reaction;90%
kaempferol
520-18-3

kaempferol

L-proline
147-85-3

L-proline

kaempferol L-proline cocrystals (1:2)

kaempferol L-proline cocrystals (1:2)

Conditions
ConditionsYield
In tetrahydrofuran; methanol at 50℃;89.6%
kaempferol
520-18-3

kaempferol

kaempferol 3-O-N-acetylglucosamine

kaempferol 3-O-N-acetylglucosamine

Conditions
ConditionsYield
With 3-O-glycosyltransferase from Scutellaria baicalensis In dimethyl sulfoxide at 45℃; for 4h; pH=9; Enzymatic reaction; regiospecific reaction;88%
5-fluorouracil
51-21-8

5-fluorouracil

kaempferol
520-18-3

kaempferol

C15H10O6*C4H3FN2O2

C15H10O6*C4H3FN2O2

Conditions
ConditionsYield
In ethanol at 20℃; for 24h;83.3%
In ethanol at 20℃; for 5h; Solvent;83.3%
UDP-glucose
133-89-1

UDP-glucose

kaempferol
520-18-3

kaempferol

kaempferol 7-glucoside
16290-07-6

kaempferol 7-glucoside

Conditions
ConditionsYield
With glycosyltransferase from Carthamus tinctorius (L.) (Honghua) recombinant In dimethyl sulfoxide at 30℃; for 12h; pH=7.4; Enzymatic reaction;80%
With flavonoid 7-O-glucosyltransferase from Andrographis paniculata In methanol at 30℃; for 12h; Enzymatic reaction;
uridine 5'-diphospho-D-galactose
2956-16-3

uridine 5'-diphospho-D-galactose

kaempferol
520-18-3

kaempferol

Conditions
ConditionsYield
With 3-O-glycosyltransferase from Scutellaria baicalensis In dimethyl sulfoxide at 45℃; for 4h; pH=9; Catalytic behavior; Enzymatic reaction; regiospecific reaction;79%
With 7-O-glucosyltransferase from Epimedium pseudowushanense In dimethyl sulfoxide at 30℃; for 12h; pH=7.4; Green chemistry; Enzymatic reaction;17.1%
kaempferol
520-18-3

kaempferol

methyl iodide
74-88-4

methyl iodide

3,4',5,7-tetramethoxyflavone
16692-52-7

3,4',5,7-tetramethoxyflavone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 15h; Inert atmosphere;78%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

kaempferol
520-18-3

kaempferol

zinc(II) chloride
7646-85-7

zinc(II) chloride

(κ2-O,O-kaempferol)(κ2-N,N-1,10-phenanthroline)zinc(II) chloride
1482348-51-5

(κ2-O,O-kaempferol)(κ2-N,N-1,10-phenanthroline)zinc(II) chloride

Conditions
ConditionsYield
Stage #1: kaempferol; zinc(II) chloride With sodium hydroxide In methanol at 20℃; for 1h;
Stage #2: 1,10-Phenanthroline In methanol for 2h; Reflux;
77%
formaldehyd
50-00-0

formaldehyd

kaempferol
520-18-3

kaempferol

dimethyl amine
124-40-3

dimethyl amine

8-((dimethylamino)methyl)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

8-((dimethylamino)methyl)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

Conditions
ConditionsYield
In ethanol at 20℃; for 0.5h; Mannich Aminomethylation;76%
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

kaempferol
520-18-3

kaempferol

zinc(II) chloride
7646-85-7

zinc(II) chloride

(κ2-O,O-kaempferol)(κ2-N,N-2,20-bipyridine)zinc(II) chloride
1482348-52-6

(κ2-O,O-kaempferol)(κ2-N,N-2,20-bipyridine)zinc(II) chloride

Conditions
ConditionsYield
Stage #1: kaempferol; zinc(II) chloride With sodium hydroxide In methanol at 20℃; for 1h;
Stage #2: [2,2]bipyridinyl In methanol for 2h; Reflux;
75%
formaldehyd
50-00-0

formaldehyd

kaempferol
520-18-3

kaempferol

diisopropylamine
108-18-9

diisopropylamine

6-((diisopropylamino)methyl)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

6-((diisopropylamino)methyl)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

Conditions
ConditionsYield
In ethanol at 20℃; for 0.5h; Mannich Aminomethylation;74%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

copper(II) choride dihydrate

copper(II) choride dihydrate

kaempferol
520-18-3

kaempferol

(κ2-O,O-kaempferol) (κ2-N,N-1,10-phenanthroline)copper(II) chloride

(κ2-O,O-kaempferol) (κ2-N,N-1,10-phenanthroline)copper(II) chloride

Conditions
ConditionsYield
Stage #1: copper(II) choride dihydrate; kaempferol With sodium hydroxide In methanol at 20℃; for 1h;
Stage #2: 1,10-Phenanthroline In methanol for 2h; Reflux;
71%
kaempferol
520-18-3

kaempferol

dimethyl sulfate
77-78-1

dimethyl sulfate

5-hydroxy-3,4',7-trimethoxyflavone
15486-34-7

5-hydroxy-3,4',7-trimethoxyflavone

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetone at 20℃; for 1h;70%
With potassium hydroxide
With potassium carbonate; acetone
kaempferol
520-18-3

kaempferol

A

C15H8O12S2(2-)*2K(1+)
116115-04-9

C15H8O12S2(2-)*2K(1+)

B

C15H7O15S3(3-)*3K(1+)
116097-12-2

C15H7O15S3(3-)*3K(1+)

Conditions
ConditionsYield
With potassium acetate; tetra(n-butyl)ammonium hydrogensulfate; dicyclohexyl-carbodiimide In pyridine at 25℃; for 48h; Yields of byproduct given;A 69%
B n/a
kaempferol
520-18-3

kaempferol

allyl bromide
106-95-6

allyl bromide

7-O-allylkaempherol
1307876-11-4

7-O-allylkaempherol

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In water; N,N-dimethyl-formamide at 50℃; for 3h;69%
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

copper(II) choride dihydrate

copper(II) choride dihydrate

kaempferol
520-18-3

kaempferol

(κ2-O,O-kaempferol)(κ2-N,N-2,2'-bipyridine)copper(II) chloride
1482348-49-1

(κ2-O,O-kaempferol)(κ2-N,N-2,2'-bipyridine)copper(II) chloride

Conditions
ConditionsYield
Stage #1: copper(II) choride dihydrate; kaempferol With sodium hydroxide In methanol at 20℃; for 1h;
Stage #2: [2,2]bipyridinyl In methanol for 2h; Reflux;
68%
kaempferol
520-18-3

kaempferol

Hexanoyl chloride
142-61-0

Hexanoyl chloride

3,7,4'-tri(O-hexanoyl)kaempferol

3,7,4'-tri(O-hexanoyl)kaempferol

Conditions
ConditionsYield
With triethylamine In acetone at 0 - 20℃; for 3h;68%
With triethylamine In acetone at 20℃; Inert atmosphere;61%

520-18-3Relevant articles and documents

Flavonoids as effective protectors of urease from ultrasonic inactivation in solutions

Tarun,Kurchenko,Metelitza

, p. 352 - 359 (2006)

Inactivation of soybean urease in aqueous solution at pH 5.4, 36°C, and high-frequency sonication (2.64 MHz, 1.0 W/cm2) is substantially reduced in the presence of seven structurally different flavonoids. A comparative kinetic study of the effect of these flavonoids on the effective first-order rate constants that characterize the total (thermal and ultrasonic) inactivation k i , thermal inactivation k*i, and ultrasonic inactivation k i (US) of 25 nM enzyme solution was carried out. The dependences of the three inactivation rate constants of the urease on the concentrations of flavonoids within the range from 10-11 to 10-4 M were obtained. The following order of the efficiency of the flavonoids used in respect of the urease protection from ultrasonic inactivation was found: astragalin > silybin > naringin > hesperidin > quercetin > kaempferol > morin. The results confirm a significant role in the inactivation of the urease of HO. and HO 2 . free radicals, which are formed in the ultrasonic cavitation field. Pleiades Publishing, Inc., 2006.

KAEMPFEROL DERIVATIVES FROM THE FRUIT OF THE JAPANESE PAGODA TREE

Akhmedkhodzhaeva, N. M.,Svechnikova, A. N.

, p. 116 - 117 (1983)

-

-

Gumenyuk et al.

, (1971)

-

Tannins, flavonol sulfonates, and a norlignan from Phyllanthus virgatus

Huang, Yu-Lin,Chen, Chien-Chih,Hsu, Feng-Lin,Chen, Chieh-Fu

, p. 1194 - 1197 (1998)

Investigation of the constituents of Phyllanthus virgatus has led to the isolation of five new compounds, including a norlignan, 2-(3,4- methylenedioxybenzyl)-4-(3,4-methylenedioxyphenyl)-3-butyne-1,2-diol named virgatyne (1); a hydrolyzable tannin, virganin (2); and three flavonoid sulfonates, galangin-8-sulfonate (4), galangin-3-O-β-D-glucoside-8- sulfonate (5), and kaempferol-8-sulfonate (6). Their structures were established by spectral and chemical methods.

FLAVONOIDS OF THE FLOWERS OF Cyclachaena xanthifolia

Kurkin, V. A.,Zapesochnaya, G. G.,Krivenchuk, P. E.,Yurkenik, A. Yu.,Artamonova, L. P.

, p. 366 - 367 (1984)

-

A new acylated flavonol glycoside from the aerial parts of Cardamine tangutorum

Feng, Wei-Sheng,Zhang, Qiu-Bo,Zheng, Xiao-Ke,Chen, Hui,Zhang, Yan-Li,Zhang, Chun-Lei

, p. 805 - 810 (2012)

A new acylated flavonol glycoside, kaempferol-3-O-β-d-(2- feruloylglucopyranosyl) (1 → 6)-[β-d-glucopyranosyl(1 → 2)]-β-d-glucopyranoside, named tangutorumoside A (1), together with 12 known compounds, was isolated from 50% acetone extract of Cardamine tangutorum. Their structures were elucidated by NMR and MS experiments. In addition, compound 1 could promote the proliferation of splenic lymphocytes and thymic lymphocytes with ConA in vitro.

-

Roshchin

, (1977)

-

-

Samokish,Shinkurenko

, (1969)

-

Anti-complement activity of tiliroside from the flower buds of Magnolia fargesii

Jung, Keun Young,Oh, Sei Ryang,Park, Si-Hyung,Lee, Im Seon,Ahn, Kyung Seop,Lee, Jung Joon,Lee, Hyeong-Kyu

, p. 1077 - 1078 (1998)

As part of the search for anticomplementary active components from natural products, the anticomplementary properties of methanolic extracts from the flower buds of Magnolia fargesii have been investigated. Bioassay- guided chromatographic Separation of the active constituents led to the isolation of compound 1, whose structure was identified by spectroscopic methods to be kaempferol 3-O-β-D-(6-O-coumaroyl)glucopyranoside (tiliroside). Tiliroside showed very potent anti-complement activity (IC50=5.4x 10-5 M) on the classical pathway of the complement system, even higher than rosmarinic acid, which is a well-known inhibitor against the complement system. On the other hand, the hydrolysates of tiliroside, kaempferol, astragalin and p-coumaric acid showed very weak activity on this system.

-

Betkhi Tkhuan',Blinova

, (1974)

-

Synthesis and Biological Evaluation of 4-Substituted Kaempfer-3-ols

Kim, Sugyeom,Lannigan, Deborah A.,Li, Yu,Lin, Lin,O'Doherty, George A.,Sayasith, Peyton R.,Tarr, Ariel T.,Wright, Eric B.,Yasmin, Sharia

, p. 4279 - 4288 (2020/04/09)

The synthesis of two series of five kaempfer-3-ols was described. The first set all have a C-3 hydroxyl group and the second has a carboxymethoxy ether at the C-3 position. Both series have variable substitution at the C-4 position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proliferation.

Flavonoid glycosides from seeds of Hippophae rhamnoides subsp. Sinensis with α-glucosidase inhibition activity

Li, Rui,Wang, Qing,Zhao, Menghao,Yang, Peiming,Hu, Xiao,Ouyang, Danwei

, (2019/07/04)

Hippophae rhamnoides subsp. Sinensis is a famous traditional medicinal plant in Tibet and Mongolia of China. Three novel flavonoid glycosides and ten known analogues were obtained from the seeds of H. rhamnoides. The structures of new compounds were elucidated by spectroscopics, chemical methods as well as literature data. In vitro assay, compounds 5–9, kaempferol and 70% ethanolic elution fraction showed prominent α-glucosidase inhibitory activities with IC50 values ranging from 8.30 to 112.11 μM, better than that of the positive control, acarbose, whose IC50 value was 1727.07 μM.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 520-18-3