- Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: Discovery of a highly potent in vivo inhibitor and its action mechanism
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Several neurological disorders manifest symptoms that result from the degeneration and death of specific neurons. p53 is an important modulator of cell death, and its inhibition could be a therapeutic approach to several neuropathologies. Here, we report
- Pietrancosta, Nicolas,Moumen, Anice,Dono, Rosanna,Lingor, Paul,Planchamp, Veronique,Lamballe, Fabienne,B?hr, Mathias,Kraus, Jean-Louis,Maina, Flavio
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- PIFITHRIN ANALOGUES AND METHODS OF TREATING RETT SYNDROME
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Disclosed herein are Pifithrin compounds, methods of treating Rett Syndrome, brain fusion organoids comprising a fusion between a cerebral cortex (Cx) organoid and the ganglionic eminence (GE) organoid, one of which comprises, consists essentially of, or
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- Imidazothiazole Derivatives or Its Pharmaceutically Acceptable Salts and Pharmaceutical Use Thereof
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The present invention relates to a novel imidazothiazole compound for inhibiting an NF-andkappa;B activity, and to a medical use thereof. More specifically, a novel imidazothiazole derivative according to the present invention has inhibited the generation
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- Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same
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Methods of modulating the activity of multidrug transporters are disclosed. The methods of modulating the activity of multidrug transporters use compounds that selectively increase or decrease the efflux capabilities of the multidrug transporter. The methods can be used therapeutically to enhance performance of therapeutic drugs, like chemotherapeutic drugs and antibiotics; to promote detoxification of cells and tissues; and to increase or decrease the efficacy of the blood-brain barrier or placental barrier.
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- Condensed Tetrahydrobenzothiazoles: Part III - Synthesis of 2-Aryl-5,6,7,8-tetrahydroimidazobenzothiazoles and 1,2,3,4-Tetrahydrobenzimidazobenzothiazoles and Their 4/5 Carbethoxy Derivatives
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2-Aryl-5,6,7,8-tetrahydroimidazobenzothiazoles (III) have been prepared by the condensation of substituted 2-amino-4,5,6,7-tetrahydrobenzothiazoles (I) with phenacyl bromides (II), while 1,2,3,4-tetrahydrobenzimidazobenzothiazoles (IXa) have
- Balse, Mukta N.,Mahajanshetti, C. S.
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p. 263 - 265
(2007/10/02)
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