60477-34-1

Usage

Uses

Used in Pharmaceutical Industry:
CYCLIC-PIFITHRIN-ALPHA is used as a research tool for studying the role of p53 in various cellular processes and diseases. Its ability to inhibit p53-dependent transactivation and apoptosis makes it a valuable compound for investigating the mechanisms underlying p53-mediated cell cycle regulation, DNA repair, and cell death.
Used in Cancer Research:
In cancer research, CYCLIC-PIFITHRIN-ALPHA is used as a potential therapeutic agent for targeting p53-dependent pathways in cancer cells. Its inhibition of p53-mediated apoptosis and transactivation of p53-responsive genes may help in the development of novel cancer treatments, particularly for tumors with p53 mutations or overexpression.
Used in Drug Resistance Studies:
CYCLIC-PIFITHRIN-ALPHA is used as a P-gp modulator to study the role of P-glycoprotein in multidrug resistance. By altering the substrate specificity of the transporter, CYCLIC-PIFITHRIN-ALPHA may help in understanding the mechanisms of drug resistance and the development of strategies to overcome it.
Used in Neurodegenerative Disease Research:
CYCLIC-PIFITHRIN-ALPHA is used as a research tool to investigate the role of p53 in neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's disease. Its ability to inhibit p53-dependent pathways may provide insights into the molecular mechanisms underlying these diseases and aid in the development of potential therapeutic strategies.
Used in Transcription Factor Inhibition:
As a potent inhibitor of STAT6 transcription, CYCLIC-PIFITHRIN-ALPHA is used in research to study the role of STAT6 in various cellular processes, including cell growth, differentiation, and immune responses. Its inhibition of STAT6 transcription may help in understanding the molecular mechanisms involved in these processes and the development of targeted therapies for related diseases.

Biochem/physiol Actions

Cell permeable: yes

Upstream product

• 2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 
• 619-41-0 4-(bromoacetyl)toluene 
• 63208-82-2 pifithrin-α 
• 108-94-1 cyclohexanone 
• 206983-57-5 pifithrin‐α 

Relevant academic research and scientific papers

Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: Discovery of a highly potent in vivo inhibitor and its action mechanism

Several neurological disorders manifest symptoms that result from the degeneration and death of specific neurons. p53 is an important modulator of cell death, and its inhibition could be a therapeutic approach to several neuropathologies. Here, we report

PIFITHRIN ANALOGUES AND METHODS OF TREATING RETT SYNDROME

Disclosed herein are Pifithrin compounds, methods of treating Rett Syndrome, brain fusion organoids comprising a fusion between a cerebral cortex (Cx) organoid and the ganglionic eminence (GE) organoid, one of which comprises, consists essentially of, or

Imidazothiazole Derivatives or Its Pharmaceutically Acceptable Salts and Pharmaceutical Use Thereof

The present invention relates to a novel imidazothiazole compound for inhibiting an NF-andkappa;B activity, and to a medical use thereof. More specifically, a novel imidazothiazole derivative according to the present invention has inhibited the generation

Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same

Methods of modulating the activity of multidrug transporters are disclosed. The methods of modulating the activity of multidrug transporters use compounds that selectively increase or decrease the efflux capabilities of the multidrug transporter. The methods can be used therapeutically to enhance performance of therapeutic drugs, like chemotherapeutic drugs and antibiotics; to promote detoxification of cells and tissues; and to increase or decrease the efficacy of the blood-brain barrier or placental barrier.

Condensed Tetrahydrobenzothiazoles: Part III - Synthesis of 2-Aryl-5,6,7,8-tetrahydroimidazobenzothiazoles and 1,2,3,4-Tetrahydrobenzimidazobenzothiazoles and Their 4/5 Carbethoxy Derivatives

2-Aryl-5,6,7,8-tetrahydroimidazobenzothiazoles (III) have been prepared by the condensation of substituted 2-amino-4,5,6,7-tetrahydrobenzothiazoles (I) with phenacyl bromides (II), while 1,2,3,4-tetrahydrobenzimidazobenzothiazoles (IXa) have