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60477-34-1

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60477-34-1 Usage

General Description

A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.

Biochem/physiol Actions

Cell permeable: yes

Check Digit Verification of cas no

The CAS Registry Mumber 60477-34-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,4,7 and 7 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 60477-34:
(7*6)+(6*0)+(5*4)+(4*7)+(3*7)+(2*3)+(1*4)=121
121 % 10 = 1
So 60477-34-1 is a valid CAS Registry Number.

60477-34-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole

1.2 Other means of identification

Product number -
Other names Pifithrin-Beta

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60477-34-1 SDS

60477-34-1Downstream Products

60477-34-1Relevant articles and documents

Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: Discovery of a highly potent in vivo inhibitor and its action mechanism

Pietrancosta, Nicolas,Moumen, Anice,Dono, Rosanna,Lingor, Paul,Planchamp, Veronique,Lamballe, Fabienne,B?hr, Mathias,Kraus, Jean-Louis,Maina, Flavio

, p. 3645 - 3652 (2006)

Several neurological disorders manifest symptoms that result from the degeneration and death of specific neurons. p53 is an important modulator of cell death, and its inhibition could be a therapeutic approach to several neuropathologies. Here, we report

Imidazothiazole Derivatives or Its Pharmaceutically Acceptable Salts and Pharmaceutical Use Thereof

-

, (2017/05/10)

The present invention relates to a novel imidazothiazole compound for inhibiting an NF-andkappa;B activity, and to a medical use thereof. More specifically, a novel imidazothiazole derivative according to the present invention has inhibited the generation

Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same

-

, (2008/06/13)

Methods of modulating the activity of multidrug transporters are disclosed. The methods of modulating the activity of multidrug transporters use compounds that selectively increase or decrease the efflux capabilities of the multidrug transporter. The methods can be used therapeutically to enhance performance of therapeutic drugs, like chemotherapeutic drugs and antibiotics; to promote detoxification of cells and tissues; and to increase or decrease the efficacy of the blood-brain barrier or placental barrier.

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