- A process for preparing 2-substituted-4-methyl-3-thiazole-oxazoline compounds method of
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The invention provides a method for preparing a 2-substituent-4-methyl-3-thiazoline compound. The method is characterized by comprising the following steps: by taking absolute ethanol or water as a solvent and adopting edible spice-2,5-dimethyl-2,5-dyhydroxyl-1,4-dithiane, aldehyde edible spice and a processing aid ammonia water for food industry as raw materials, reacting at 5-45 DEG C for 20-90 minutes to obtain 2-substituent-4-methyl-3-thiazoline, wherein the molar ratio of 2,5-dimethyl-2,5-dyhydroxyl-1,4-dithiane to aldehyde is (1 : 2) to (1 : 3), and the molar ratio of aldehyde to ammonia water is (1 : 1) to (1 : 2); after the reaction is finished, post-treating to remove low-boiling-point substances, and performing reduced pressure distillation to obtain the 2-substituent-4-methyl-3-thiazoline compound. The method is simple to carry out and easy for industrialization, and the raw materials used in the method are safe and easily available.
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Paragraph 0021-0022
(2018/02/04)
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