60756-86-7

Basic information

• Product Name: 4-hydroxypiperidinocyclohexyl carbonitrile
• Synonyms: 4-hydroxypiperidinocyclohexyl carbonitrile
• CAS NO: 60756-86-7
• Molecular Weight: 208.304
• Mol File: 60756-86-7.mol

Chemical Properties

• CAS DataBase Reference: 4-hydroxypiperidinocyclohexyl carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxypiperidinocyclohexyl carbonitrile(60756-86-7)
• EPA Substance Registry System: 4-hydroxypiperidinocyclohexyl carbonitrile(60756-86-7)

Safety Data

• Hazardous Substances Data: 60756-86-7(Hazardous Substances Data)

Upstream product

• 151-50-8 potassium cyanide 
• 108-94-1 cyclohexanone 
• 5382-17-2 piperidin-4-ol hydrochloride 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 773837-37-9 sodium cyanide 

Downstream Products

• 60232-85-1 1-(1-phenylcyclohexyl)-4-hydroxypiperidine 
• 77179-35-2 Benzoic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 77179-36-3 Nicotinic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 77179-37-4 4-Amino-benzoic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 77179-34-1 3,4-Dimethoxy-benzoic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 1165754-52-8 1-[1-(4-methoxyphenyl) (cyclohexyl)]-4-piperidinol 
• 1165754-50-6 1-[1-(4-methylphenyl) (cyclohexyl)]-4-piperidinol 
• 1372710-25-2 1-[1-[3-hydroxy-5-methylphenyl][cyclohexyl]]-4-piperidinol 

Relevant articles and documents

Synthesis and antinociceptive behaviors of new methyl and hydroxyl derivatives of phencyclidine

Phencyclidine (I) and its derivatives show such pharmacological behaviors as analgesic, anticonsulvant, anti-anxiety and antidepressant, while interacting with central nervous system. In this study, new methyl and hydroxyl derivatives of PCP were synthesized and their antinociceptive behaviors in animals were examined by measuring the number of writhing in a writhing test of visceral pain and the pain scores in Formalin test. Compared to control and PCP groups, findings in experimental groups indicated the new synthesized analogues (compounds II, III and V, 10 mg/kg) of PCP were able to produce more analgesic effects in formalin and writhing tests, especially for compound V. It was concluded that the new synthesized derivatives of PCP could substantially and respectively diminish acute and chronic pains.

Synthesis and study on analgesic effects of 1-[1-(4-methylphenyl) (cyclohexyl)] 4-piperidinol and 1-[1-(4-methoxyphenyl) (cyclohexyl)] 4-piperidinol as two new phencyclidine derivatives

Phencyclidine (1-(1-phenylcyclohexyl) piperidine; CAS 956-90-1; PCP, I) has shown analgesic effects. Some of its derivatives have been synthesized and their biological properties have been studied. In this work, new methyl and methoxy hydroxyl derivatives of phencyclidine were synthesized and the analgesic effects of this compounds [(1-[1-(4-methylphenyl) (cyclohexyl)] 4-piperidinol, II), (1-[1-(4-methoxyphenyl) (cyclohexyl)] 4-piperidinol, III)] were studied using tail immersion test on rats and compared to PCP. The results showed that, II can produce more analgesic effects in the tail immersion test (as a model of acute thermal pain) in comparison to the PCP with a marked significant increase in tail immersion latency (15, 40 and 45 min after injection) but for III, only slight analgesic effects (15, 35 and 40 min after injection) was seen (without significant differences between pain thresholds). ECV Editio Cantor Verlag.

1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vitro: Synthesis, identification from rat liver microsome extracts, and affinity for the neuronal dopamine transporter

1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP, 1) and cocaine bind to the neuronal dopamine transporter to inhibit dopamine (DA) reuptake. However, on chronic administration, cocaine produces sensitization, but 1 produces tolerance

Synthesis and analgesic activity of new phencyclidine derivatives

New phencyclidine derivatives having structural similarities with the well known 4-phenylpiperidine narcotic analgesics were synthesized, characterized and their anti-nociceptive activity tested in mice by the hot-plate and tail-flick tests. Structure, activity relationships for these compounds further point to the importance of a second aryl moiety at position 4 of the piperidine ring of phencyclidine. In addition, the presence of a hydroxyl group in close proximate to the lipophilic moiety is vital for analgesic activity.

Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies

The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them. The tracers and the immunogens are made from substituted phencyclidine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.