60232-85-1 Usage
Description
1-(1-phenylcyclohexyl)-4-hydroxypiperidine, also known as 4-Hydroxy Phencyclidine, is a chemical compound derived from Phencyclidine (P295502). It is a major monohydroxy metabolite that exhibits PCP-like stimuli. 1-(1-phenylcyclohexyl)-4-hydroxypiperidine has a complex structure with a phenylcyclohexyl group attached to a piperidine ring, featuring a hydroxyl group at the 4-position.
Uses
1. Used in Pharmaceutical Research:
1-(1-phenylcyclohexyl)-4-hydroxypiperidine is used as a research compound for understanding the effects and mechanisms of action of Phencyclidine (PCP) and its metabolites. Its PCP-like stimuli make it a valuable tool in studying the neurological and psychoactive properties of PCP, which can contribute to the development of new therapeutic strategies for related conditions.
2. Used in Toxicology and Drug Metabolism Studies:
As a metabolite of Phencyclidine, 1-(1-phenylcyclohexyl)-4-hydroxypiperidine is utilized in toxicology and drug metabolism research. It helps scientists investigate the metabolic pathways and toxic effects of PCP, which can be crucial for assessing the risks and safety profiles of similar compounds.
3. Used in Drug Development:
1-(1-phenylcyclohexyl)-4-hydroxypiperidine may also be used in the development of new drugs with similar structures or mechanisms of action. By studying the properties and effects of 1-(1-phenylcyclohexyl)-4-hydroxypiperidine, researchers can gain insights into designing more effective and safer medications for various applications.
4. Used in Analytical Chemistry:
1-(1-phenylcyclohexyl)-4-hydroxypiperidine can be employed as a reference material or standard in analytical chemistry, particularly in the development and validation of analytical methods for the detection and quantification of PCP and its metabolites in biological samples.
5. Used in Forensic Science:
In forensic science, the compound can be used for the identification and analysis of PCP and its metabolites in cases involving drug-related crimes or toxicological investigations.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 24, p. 496, 1981 DOI: 10.1021/jm00137a004
Check Digit Verification of cas no
The CAS Registry Mumber 60232-85-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,3 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60232-85:
(7*6)+(6*0)+(5*2)+(4*3)+(3*2)+(2*8)+(1*5)=91
91 % 10 = 1
So 60232-85-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H25NO/c19-16-9-13-18(14-10-16)17(11-5-2-6-12-17)15-7-3-1-4-8-15/h1,3-4,7-8,16,19H,2,5-6,9-14H2
60232-85-1Relevant articles and documents
IDENTIFICATION OF PHENCYCLIDINE METABOLITES BY THE METHOD OF CHROMATO-MASS SPECTROMETRY
Addison, J. B.
, p. 215 - 217 (1981)
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Synthesis and analgesic activity of new phencyclidine derivatives
Al-Deeb
, p. 1141 - 1144 (2007/10/02)
New phencyclidine derivatives having structural similarities with the well known 4-phenylpiperidine narcotic analgesics were synthesized, characterized and their anti-nociceptive activity tested in mice by the hot-plate and tail-flick tests. Structure, activity relationships for these compounds further point to the importance of a second aryl moiety at position 4 of the piperidine ring of phencyclidine. In addition, the presence of a hydroxyl group in close proximate to the lipophilic moiety is vital for analgesic activity.
Application of chemical P450 model systems to studies on drug metabolism. I. Phencyclidine: A multi-functional model substrate
Masumoto,Takeuchi,Ohta,Hirobe
, p. 1788 - 1794 (2007/10/02)
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