Preparative and Regiochemical Aspects of the Palladium-Catalyzed Carbonylative Coupling of 2-Hydroxyaryl Iodides with Ethynylarenes
The title reaction has been conveniently carried out in DMF at 60 deg C under 1 atm CO pressure using DBU as the base and Pd(OAc)2(DPPF)2 as the catalyst to afford generally mixtures of flavones 4 and aurones 5 in varying yields, depending on the substituents in the both reactants.Factors controlling the regioselectivity for 4 or 5 formation in this and in similar, previously reported, coupling procedures have been examined.
Synthesis and Reaction of 3-Bromoflavanones with DMSO
Bromination of flavanones (I) with (2-carboxyethyl)triphenylphosphonium perbromide gives the corresponding 3-bromoflavanones (II) which when treated with DMSO at room temperature undergo dehydrobromination to flavones (III).
Sharma, T. C.,Pawar, S. R.,Reddy, N. J.,Donnelly, John A.
p. 80 - 81
(2007/10/02)
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