60939-21-1Relevant articles and documents
Mechanistic investigation of the oxidative cleavage of the carbon-carbon double bond in α,β-Unsaturated compounds by hexachloroiridate(iv) in acetate buffer
Pal, Biswajit
, p. 31 - 40 (2014/01/06)
The hexachloroiridate(IV) oxidation of α,β-unsaturated compounds such as acrylic acid, acrylamide, and acrylonitrile (CH2=CHX; X = -COOH, -CONH2, and -CN) was carried out in NaOAc-AcOH buffer medium. The reaction follows complex kinetics, being first order in [IrIV] and complex order in [CH2=CHX]. H+ ion has no effect on the reaction rate in the pH range 3.42-4.63. The pseudo-first-order rate constant decreases with a decrease in the dielectric constant and with a decrease of ionic strength of the medium. The oxidation rate follows the sequence: acrylonitrile > acrylamide > acrylic acid. A mechanism is proposed involving the formation of an unstable intermediate complex between the substrate and the oxidant which is transformed to the radical cation in a slow rate-determining step with the concomitant reduction of Ir(IV) to Ir(III). The radical cation subsequently decomposes to the aldehyde that appears as the ultimate product of the carbon-carbon double bond cleavage. The major product of oxidation was identified as HCHO by 1H NMR. Activation parameters for the slow rate-determining step and thermodynamic parameters associated with the equilibrium step of the proposed mechanism have been evaluated. The enthalpy of activation is linearly related to the entropy of activation, and this linear relationship confirms that the oxidation of all the α,β-unsaturated compounds follows a common mechanism.
Oxidation of some α,β-unsaturated compounds by bromate ion in hydrochloric acid medium
Debnath, Nandadulal,Pal, Biswajit,Gupta, Kalyan Kali Sen
, p. 351 - 355 (2007/10/03)
The oxidation kinetics of some α,β-unsaturated compounds, CH2=CHX (X = COOH, CONH2, CN) by potassium bromate in hydrochloric acid medium have been studied. The activation parameters of the reactions have been evaluated. The reactivity of the α,β-unsaturated compounds is as follows: COOH 2 CN. A mechanism involving the formation of an unstable bromate ester which decomposes to the reaction products has been suggested.
Oxidation of aminodinitrotoluenes with ozone: Products and pathways
Spanggord, Ronald J.,Yao, C. David,Mill, Theodore
, p. 497 - 504 (2007/10/03)
An investigation of the products from the reaction of ozone with aminodinitrotoluenes (ADNTs) provides information about the oxidation pathway. Studies conducted at low conversions of 2- and 4-ADNT show 2:1 ozone/ADNT stoichiometries, prompt formation of glyoxylic and pyruvic acids, and NO2- and NO3- (NOx) ions. Reaction schemes to account for these results involve a 1,3-dipolar cycloaddition of ozone to selected double bonds of the aromatic ring, leading to ring cleavage. 15N-Labeling experiments indicate that the amino function is not involved in the initial ozone oxidation and eventually is incorporated into pyruvamide (2-ADNT) and oxamic acid (4-ADNT) before being oxidized to nitrate.
Method of treating pain and hypertension
-
, (2008/06/13)
3-[2-(Phenyloxycycloazalkyl)ethyl]indoles possessing antihypertensive, analgesic, and tranquilizing properties and process for their preparation are described.
