610300-07-7

Basic information

• Product Name: (3S,5R)-3-Amino-5-methyloctanoic acid
• Synonyms: (3S,5R)-3-Amino-5-methyloctanoic acid;IMagabalin;PD 0332334;PF 00195889;JXEHXYFSIOYTAH-SFYZADRCSA-N
• CAS NO: 610300-07-7
• Molecular Formula: C9H19NO2
• Molecular Weight: 173.25
• Mol File: 610300-07-7.mol

Chemical Properties

• Boiling Point: 282.945 °C at 760 mmHg
• Flash Point: 124.921 °C
• Appearance: /
• Density: 0.983
• CAS DataBase Reference: (3S,5R)-3-Amino-5-methyloctanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5R)-3-Amino-5-methyloctanoic acid(610300-07-7)
• EPA Substance Registry System: (3S,5R)-3-Amino-5-methyloctanoic acid(610300-07-7)

Safety Data

• Hazardous Substances Data: 610300-07-7(Hazardous Substances Data)

Usage

Uses

Imagabalin is an oral drug that is used for treatment-resistant depression and anxiety

Upstream product

• 610300-51-1 (5S)-5-methyl-octa-2,6-dienoic acid tert-butyl ester 
• 610300-52-2 (S)-3-methyl-hex-4-enoic acid ethyl ester 
• 610300-36-2 (3S,5R)-3-amino-5-methyl-octanoic acid tert-butyl ester 
• 663920-91-0 (3R,5S)-3-[benzyl-(1-phenyl-ethyl)-amino]-5-methyl-oct-6-enoic acid tert-butyl ester 

Relevant articles and documents

METHODS FOR USING AMINO ACIDS WITH AFFINITY FOR THE ALPHA-2-DELTA PROTEIN

This invention relates to certain ?-amino acids that bind to the alpha-2-delta ((x2S) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.

Combinations

The instant invention relates to a combination of an alpha-2-delta ligand and an AChE inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. Particularly preferred ACHE inhibitors are donepezil (Aricept?), tacrine (cognex?), rivastigmine (Exelon?), physostgmine (Synapton?), galantamine (Reminyl), metrifonate (Promem), neostigmine (Prostigmin) and icopezil.

Synergistic combinations

The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the curative, prophylactic or palliative treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. Particularly preferred PDEV inhibitors are sildenafil, vardenafil and tadalafil.

Amino acids with affinity for the alpha-2-delta-protein

This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.