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CAS

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611187-05-4

2-(Benzyloxy)isoquinoline-1,3(2H,4H)-dione is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a benzyloxy group attached to the isoquinoline core, which contributes to its unique chemical properties and reactivity.

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  • 611187-05-4 Structure

  • Basic information

    1. Product Name: 2-(benzyloxy)isoquinoline-1,3(2H,4H)-dione
    2. Synonyms: 2-(benzyloxy)isoquinoline-1,3(2H,4H)-dione
    3. CAS NO:611187-05-4
    4. Molecular Formula: C16H13NO3
    5. Molecular Weight: 267.27932
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 611187-05-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C Freezer
    8. Solubility: DMSO; Methanol
    9. CAS DataBase Reference: 2-(benzyloxy)isoquinoline-1,3(2H,4H)-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(benzyloxy)isoquinoline-1,3(2H,4H)-dione(611187-05-4)
    11. EPA Substance Registry System: 2-(benzyloxy)isoquinoline-1,3(2H,4H)-dione(611187-05-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 611187-05-4(Hazardous Substances Data)

611187-05-4 Usage

Uses

Used in Pharmaceutical Industry:
2-(Benzyloxy)isoquinoline-1,3(2H,4H)-dione is used as an intermediate in the synthesis of 2-Hydroxyisoquinoline-1,3(2H,4H)-dione (H939800), a compound with potential antiviral properties. It plays a crucial role in the development of new drugs targeting HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase, offering a promising avenue for the treatment of HIV infections.
Used in Antiviral Research:
2-(Benzyloxy)isoquinoline-1,3(2H,4H)-dione is utilized in the study of antiviral agents, particularly focusing on its interaction with metal ions such as Mg2+ and Mn2+. Its ability to form complexes with these ions has been investigated using various spectroscopic techniques, providing valuable insights into its potential use as an antiviral agent.

Check Digit Verification of cas no

The CAS Registry Mumber 611187-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,1,1,8 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 611187-05:
(8*6)+(7*1)+(6*1)+(5*1)+(4*8)+(3*7)+(2*0)+(1*5)=124
124 % 10 = 4
So 611187-05-4 is a valid CAS Registry Number.

611187-05-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-benzyloxyisoquinoline-1,3(2H,4H)-dione

1.2 Other means of identification

Product number -
Other names 2-(Benzyloxy)isoquinoline-1,3(2H,4H)-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:611187-05-4 SDS

611187-05-4Relevant articles and documents

4-benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors

Senaweera, Sameera,He, Tianyu,Cui, Haixi,Aihara, Hideki,Wang, Zhengqiang

, p. 371 - 386 (2020/11/23)

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase II (Top2) mediated DNA damages, including double-strand breaks (DSBs) that underpin the anticancer mechanism of clinical Top2 poisons such as etoposide (ETP). Inhibition of TDP2 could sensitize

AN ANTIVIRAL AGENT INHIBITING RNase H ACTIVITY OF DNA POLYMERASE OF HEPATITIS B VIRUS

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Page/Page column 12, (2018/10/04)

The present invention relates to an antiviral agent inhibiting the Rnase H activity of a DNA polymerase of hepatitis B virus, and a substance of the present invention has a target different from a target of a nucleoside drug such as entecavir, which is a

Method for selection of hDIS3 PIN domain inhibitors and use of hDIS3 PIN domain inhibitors for cancer treatment

-

Paragraph 0161-0162, (2016/04/22)

The present invention relates to a method for selection or screening of hDIS3 PIN domain inhibitors, yeast strain and cell line used in such methods It also relates to new therapeutic agents selected hDIS3 PIN domain inhibitors and uses thereof in the tre

Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain

Billamboz, Muriel,Bailly, Fabrice,Barreca, Maria Letizia,De Luca, Laura,Mouscadet, Jean-Fran?ois,Calmels, Christina,Andréola, Marie-Line,Witvrouw, Myriam,Christ, Frauke,Debyser, Zeger,Cotelle, Philippe

experimental part, p. 7717 - 7730 (2009/12/07)

We report herein the synthesis of a series of 19 2-hydroxyisoquinoline-1, 3(2H,4H)-dione derivatives variously substituted at position 7 aimed at inhibiting selectively two-metal ion catalytic active sites. The compounds were tested against HIV-1 reverse

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