61123-70-4

Basic information

• Product Name: 3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPAN-1-AMINE
• Synonyms: 3-(Indolin-1-yl)propan-1-aMine;2,3-Dihydro-1H-indole-1-propanamine;3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPAN-1-AMINE
• CAS NO: 61123-70-4
• Molecular Formula: C₁₁H₁₆N₂
• Molecular Weight: 176.26
• Mol File: 61123-70-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPAN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPAN-1-AMINE(61123-70-4)
• EPA Substance Registry System: 3-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPAN-1-AMINE(61123-70-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 61123-70-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(2,3-Dihydro-1H-indol-1-yl)propan-1-amine is used as a bioactive compound for its potential role in the development of pharmaceuticals. Its chemical structure, which includes an indole ring, is common in many bioactive molecules, suggesting that it may have applications in drug discovery and design.
Used in Dye Industry:
3-(2,3-Dihydro-1H-indol-1-yl)propan-1-amine is used as a chemical intermediate for the synthesis of dyes. Indole compounds are often used in the production of dyes due to their ability to absorb and emit light, making them suitable for colorants in various applications.
Used in Organic Synthesis:
3-(2,3-Dihydro-1H-indol-1-yl)propan-1-amine is used as a reagent or intermediate in organic synthesis. Its unique structure may allow for the creation of new compounds or the modification of existing ones, contributing to the advancement of organic chemistry.

Upstream product

• 91349-96-1 3-(indolin-1-yl)propanenitrile 
• 496-15-1 1-indoline 
• 14753-26-5 3-chloropropan-1-amine 
• 5003-71-4 3-bromopropylamine hydrochloride 
• 4414-79-3 3-(1H-indol-1-yl)propanenitrile 
• 120-72-9 indole 

Relevant articles and documents

Synthesis and Biological Evaluation of Derivatives of Indoline as Highly Potent Antioxidant and Anti-inflammatory Agents

We describe the preparation and evaluation of novel indoline derivatives with potent antioxidant and anti-inflammatory activities for the treatment of pathological conditions associated with chronic inflammation. The indolines are substituted at position 1 with chains carrying amino, ester, amide, or alcohol groups, and some have additional substituents, Cl, MeO, Me, F, HO, or BnO, on the benzo ring. Concentrations of 1 pM to 1 nM of several compounds protected RAW264.7 macrophages against H2O2 induced cytotoxicity and LPS induced elevation of NO, TNF-α, and IL-6. Several derivatives had anti-inflammatory activity at 1/100th of the concentration of unsubstituted indoline. Four compounds with ester, amine, amide, or alcohol side chains injected subcutaneously in mice at a dose of 1 μmol/kg or less, like dexamethasone (5.6 μmol/kg) prevented LPS-induced cytokine elevation in the brain and peripheral tissues. Subcutaneous injection of 100 μmol/kg of these compounds caused no noticeable adverse effects in mice during 3 days of observation.

INDOLINE DERIVATIVES, COMPOSITIONS COMPRISING THEM AND USES THEREOF

The present invention is directed to indoline derivatives and salts thereof, compositions comprising them and uses thereof for the treatment of diseases and disorders associated with at least one of oxidative stress, an immune response, release of NO and release of pro-inflammatory cytokine.

Salts of 2- or 3-haloalkylamines in the synthesis of N-aminoalkyl derivatives of heterocyclic and aromatic amines

Reactions of 2-haloethyl- or 3-halopropylamine salts with NH-substrates (indoline, 1,2,3,4-tetrahydroquinoline, aniline, and N-ethylaniline) in the presence of NaHCO3 in water furnished various N-aminoalkyl derivatives of heterocyclic and aromatic amines.

Electrooxidative cyclization of hydroquinolyl alcohols, hydroquinolylamines, and dimethyl aminomalonates

Several hydroquinolyl alcohols and amines were electrochemically oxidized in methanol in the presence of sodium methoxide and potassium iodide to afford the corresponding intramolecular cyclization products. Furthermore, several amino malonates were electrochemically oxidized to yield the corresponding heterocyclic compounds through an intramolecular carbon-carbon bond formation in the presence of sodium cyanide in methanol. CSIRO 2007.