611233-77-3

Basic information

• Product Name: 2,6-Bis(bromomethyl)-4-cyanopyridine
• Synonyms: 2,6-Bis(bromomethyl)-4-cyanopyridine
• CAS NO: 611233-77-3
• Molecular Formula: C8H6Br2N2
• Molecular Weight: 289.95464
• Mol File: 611233-77-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-Bis(bromomethyl)-4-cyanopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Bis(bromomethyl)-4-cyanopyridine(611233-77-3)
• EPA Substance Registry System: 2,6-Bis(bromomethyl)-4-cyanopyridine(611233-77-3)

Safety Data

• Hazardous Substances Data: 611233-77-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Bis(bromomethyl)-4-cyanopyridine is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure allows for the creation of new drug molecules with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 2,6-Bis(bromomethyl)-4-cyanopyridine serves as a key component in the synthesis of pesticides and other crop protection agents, contributing to the development of effective and targeted solutions for agricultural challenges.
Used in Dye Manufacturing:
2,6-Bis(bromomethyl)-4-cyanopyridine is utilized as a starting material in the production of dyes, particularly those with specific color properties and stability. Its presence in dye formulations enhances their performance in various applications, including textiles and printing inks.
Used in Organic Chemistry Research:
As a highly reactive compound, 2,6-Bis(bromomethyl)-4-cyanopyridine is employed in organic chemistry research for exploring novel reactions and mechanisms. Its unique functional groups facilitate the study of new synthetic pathways and the development of innovative chemical processes.

Upstream product

• 5093-70-9 4-bromo-2,6-dimethylpyridine 
• 39965-81-6 2,6-dimethylisonicotinonitrile 

Relevant articles and documents

Synthesis of 12-Membered Tetra-aza Macrocyclic Pyridinophanes Bearing Electron-Withdrawing Groups

The number of substituted pyridine pyridinophanes found in the literature is limited due to challenges associated with 12-membered macrocycle and modified pyridine synthesis. Most notably, the electrophilic character at the 4-position of pyridine in pyridinophanes presents a unique challenge for introducing electrophilic chemical groups. Likewise, of the few reported, most substituted pyridine pyridinophanes in the literature are limited to electron-donating functionalities. Herein, new synthetic strategies for four new macrocycles bearing the electron-withdrawing groups CN, Cl, NO2, and CF3 are introduced. Potentiometric titrations were used to determine the protonation constants of the new pyridinophanes. Further, the influence of such modifications on the chemical behavior is predicted by comparing the potentiometric results to previously reported systems. X-ray diffraction analysis of the 4-Cl substituted species and its Cu(II) complex are also described to demonstrate the metal binding nature of these ligands. DFT analysis is used to support the experimental findings through energy calculations and ESP maps. These new molecules serve as a foundation to access a range of new pyridinophane small molecules and applications in future work.

Synthesis and structural studies of 5,12-dioxocyclams capped by 4-substituted pyridines across the amine nitrogens

A series of 4-substituted pyridine-capped 5,12-dioxocyclams was synthesized and fully characterized. The 4-substituent varied from electron-withdrawing groups (NO2, NO, CN) to electron-donating groups (NHCbz, NH2). The most versatile substituent was the 4-bromo group, which could be replaced by a variety of groups using Stille, Sonogashira, or Buchwald-Hartig palladium-catalyzed chemistry. Copper complexes of a majority of these capped dioxocyclams were synthesized and characterized as well.