5093-70-9

Usage

Uses

4-Bromo-2,6-dimethylpyridine is a reagent used in the synthesis of novel isoquinoline derivatives of potential interest for pharmaceutical, biomedical, and energy-related research.

InChI:InChI=1/C7H8BrN/c1-5-3-7(8)4-6(2)9-5/h3-4H,1-2H3

Upstream product

• 3512-80-9 4-amino-2,6-lutidine 
• 13603-44-6 2,6-dimethylpyridin-4-ol 
• 520-45-6 Dehydracetic acid 
• 325142-95-8 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Downstream Products

• 3044-71-1 2,6-dimethyl-4-phenylpyridine 
• 130138-48-6 (Z)-2-(2,6-Dimethyl-pyridin-4-yl)-3-phenyl-acrylonitrile 
• 59576-38-4 (2,6-dimethylpyridin-4-yl)(phenyl)methanone 
• 130138-58-8 Benzenesulfonyl-(2,6-dimethyl-1H-pyridin-4-ylidene)-acetonitrile 
• 120491-87-4 4-bromo-2,6-bis(chloromethyl)pyridine 
• 851868-26-3 1,4-bis(2,6-dimethyl-4-pyridyl)benzene 
• 86520-95-8 4-Ethynyl-2,6-dimethylpyridine 
• 130138-46-4 (2,6-dimethylpyridin-4-yl)acetonitrile 
• 130138-45-3 α-Ethyl-2,6-dimethyl-α-phenylsulfonyl-4-pyridineacetonitrile 
• 846548-44-5 (2,6-dimethylpyridine-4-yl)boronic acid 
• 1056462-15-7 4-(4-bromo-2-fluorophenoxy)-2,6-dimethylpyridine 
• 1226799-70-7 5-(2,6-dimethylpyridin-4-yl)-5-(3-methoxyphenyl)-5H-pyrrolo[3,4-b]pyridin-7-amine 
• 1260433-07-5 2-(3-bromophenyl)-2-(2,6-dimethylpyridin-4-yl)-4-methyl-1H-imidazole-5(2H)-thione 
• 1260433-08-6 2-(3-bromophenyl)-2-(2,6-dimethylpyridin-4-yl)-5-methyl-2H-imidazol-4-amine 

Relevant academic research and scientific papers

A 2, 6 - dimethyl -4 - bromo pyridine synthesis method

The invention relates to the field of organic chemistry, in particular to a 2, 6 - dimethyl - 4 - bromo pyridine synthesis method, comprises the following steps: malonic acid diethyl ester and alkali metal reaction to produce salt, then dropwise 4 - nitro - 2 - methyl - 6 chloro pyridine to a toluene solution of a condensation reaction, after decarboxylation under acidic conditions to the 4 - nitro - 2, 6 - dimethyl pyridine; 4 - nitro - 2, 6 - dimethyl pyridine in under the catalysis of the Pd/C, methanol as the solvent, hydrogen reduction, filtered, the filtrate is concentrated, from 4 - amino - 2, 6 - dimethyl pyridine; 4 - amino - 2, 6 - dimethyl pyridine first with an acid generating salt, cooled to - 15 °C - 3 °C, [...], drops the instillment sodium nitrite aqueous solution, pH adjusting solution is dropped is alkaline, and then extracted, dried, concentrated, be 2, 6 - dimethyl - 4 - bromo pyridine. The method of the invention is beneficial effect: mild reaction conditions, high yield, and raw materials are easy, and the cost is low, the process route is short, and has industrial prospects.

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0: [Formula (1.0)] and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

Meta halogenation of 1,3-disubstituted arenes via iridium-catalyzed arene borylation

We report the meta halogenation of 1,3-disubstituted arenes to form 3,5-disubstituted aryl bromides and chlorides by using iridium-catalyzed arene borylation chemistry. Iridium-catalyzed borylation of arenes with B2pin2, followed by reaction of the boronic ester with copper(II) bromide or chloride converts arylboronic esters to the corresponding aryl halides. A variety of arenes containing alkoxy, alkyl, halogen, nitrile, ester, amide, and pivaloyl and TIPS-protected alcohols were converted to the corresponding 3,5-disubstituted aryl bromides and chlorides in yields ranging from 46% to 85%. In addition, 2,6-disubstituted and 3-substituted pyridines were converted to the 4-halo and 5-halopyridines, respectively. The utility of this methodology was demonstrated by the formal conversion of nicotine to Altinicline in three steps with an overall yield of 61% using meta bromination of nicotine as the first step. Copyright

NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

The invention provides certain compounds and salts of Formula I and Formula II:which possess antimicrobial activity. The invention also provides novel synthetic intermediatesuseful in making compounds of Formula I and Formula II. The variables A1, R2, R3, R5, R6, R7, A8, and Rg are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.

ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

The invention provides compounds and salts of Formula (I) and Formula (II): which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula (I) and Formula (II). The variables A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of a compound of Formula (I) or Formula (II) and one or more other active agents. The invention also provides methods for treating microbial infections in animals.

Synthesis of 4-(Phenylethynyl)-2,6-bispyridine

The synthesis of 4-(phenylethynyl)-2,6-bispyridine is described.Two separate routes were investigated to reach the key intermediate 4-bromo-2,6-bis(bromomethyl)pyridine.