611239-26-0

Basic information

• Product Name: 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6,7-dihydroxy-, methyl ester, (3S)- (9CI)
• Synonyms: 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6,7-dihydroxy-, methyl ester, (3S)- (9CI);(S)-methyl 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
• CAS NO: 611239-26-0
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.22522
• Product Categories: ALCOHOL
• Mol File: 611239-26-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6,7-dihydroxy-, methyl ester, (3S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6,7-dihydroxy-, methyl ester, (3S)- (9CI)(611239-26-0)
• EPA Substance Registry System: 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6,7-dihydroxy-, methyl ester, (3S)- (9CI)(611239-26-0)

Safety Data

• Hazardous Substances Data: 611239-26-0(Hazardous Substances Data)

Usage

Chemical compound

3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6,7-dihydroxy-, methyl ester, (3S)(9CI)

Potential pharmaceutical applications

This compound has the potential for pharmaceutical use.

Methyl ester derivative

This compound is a methyl ester derivative of 3-isoquinolinecarboxylic acid.

Heterocyclic compound

3-Isoquinolinecarboxylic acid is a heterocyclic compound.

Two hydroxy groups

The presence of two hydroxy groups in the 1,2,3,4-tetrahydro-6,7-dihydroxymoiety suggests potential biological activity.

Possible biological activities

It may act as an antioxidant or bind to specific receptors.

(3S)configuration

The (3S)configuration indicates a specific stereochemistry for potential biological effects.

Need for further research

Further research is needed to fully understand the properties and potential uses of this compound.

Upstream product

• 59-92-7 levodopa 
• 67-56-1 methanol 
• 34312-81-7 (3S)-6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 

Downstream Products

• 538367-15-6 (S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(3,4-dimethoxy-phenyl)-propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester 
• 538367-18-9 (3S,11aS)-3-(3,4-Dimethoxy-benzyl)-1-hydroxy-8,9-dimethoxy-4-oxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinoline-2-carboxylic acid isopropyl ester 
• 538367-17-8 (3S,11aS)-3-(3,4-Dimethoxy-benzyl)-8,9-dimethoxy-1,4-dioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinoline-2-carboxylic acid isopropyl ester 
• 538367-16-7 3-(3,4-dimethoxy-benzyl)-8,9-dimethoxy-2,3,11,11a-tetrahydro-6H-pyrazino[1,2-b]isoquinoline-1,4-dione 

Relevant articles and documents

Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands

Ruthenium complexes offer potential reduced toxicity compared to current platinum anticancer drugs. 1,2,3,4-tetrahydrisoquinoline amino alcohol ligands were synthesised, characterised and coordinated to an organometallic Ru(II) centre. These complexes were evaluated for activity against the cancer cell lines MCF-7, A549 and MDA-MB-231 as well as for toxicity in the normal cell line MDBK. They were observed to be moderately active against only the MCF-7 cells with the best IC50 value of 34 μM for the cis-dia-stereomeric complex C4. They also displayed excellent selectivity by being relatively inactive against the normal MDBK cell line with SI values ranging from 2.3 to 7.4.

A new efficient synthetic process for the construction of the pentacyclic core of marine alkaloid ecteinascidins

The pentacyclic core of ecteinascidins was constructed from two fundamental building blocks, the 1,2,3,4-tetrahydroisoquinoline derivative and the substituted phenylalanine derivative, via 8 steps using readily available L-Dopa as starting material. The k