61188-00-9

Basic information

• Product Name: Cyclohexanone, 6-(hydroxymethylene)-2,2-dimethyl-
• CAS NO: 61188-00-9
• Molecular Formula: C9H14O2
• Molecular Weight: 154.209
• Mol File: 61188-00-9.mol

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 6-(hydroxymethylene)-2,2-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 6-(hydroxymethylene)-2,2-dimethyl-(61188-00-9)
• EPA Substance Registry System: Cyclohexanone, 6-(hydroxymethylene)-2,2-dimethyl-(61188-00-9)

Safety Data

• Hazardous Substances Data: 61188-00-9(Hazardous Substances Data)

Upstream product

• 1193-47-1 2,2-dimethyl-cyclohexanone 
• 109-94-4 formic acid ethyl ester 
• 107-31-3 Methyl formate 
• 583-60-8 2-Methylcyclohexanone 
• 74-88-4 methyl iodide 

Downstream Products

• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 10219-83-7 3,3-dimethyl-2-oxocyclohexanecarbonitrile 
• 41641-14-9 1-hydroxymethyl-3,3-dimethyl-cyclohex-1-ene 
• 547-15-9 2-(6',6'-Dimethyl-2'-methylenecyclohexyl)ethanal 
• 876050-84-9 6-[6,6-Dimethoxy-hex-(Z)-ylidene]-2,2-dimethyl-cyclohexanone 

Relevant articles and documents

Total Synthesis of (+)-Antrocin and Its Diastereomer and Clarification of the Absolute Stereochemistry of (-)-Antrocin

Using 2,2-dimethyl cyclohexanone as the starting compound, (+)-antrocin and its diastereomer have been synthesized. The absolute stereochemistry of (-)-antrocin, a natural sesqui-terpenoid and an antagonist in some types of cancer cells, was clarified using the character data of (+)-antrocin. The synthetic procedure involved two key steps: (1) the reaction of vinyl magnesium bromide with 2,2-dimethyl-6-t-butyl-dimethyl-silyoxy-methyl-1-cyclo-hexanone to give a vinyl cyclohexanol derivative and (2) a highly stereoselective intramolecular Diels-Alder (IMDA) reaction of the camphanate-containing triene intermediate. The relative energy levels of the possible transition states of the IMDA reaction of the camphanate-containing triene were obtained from density functional theory calculations, proving the stereospecific formation of the target molecule.

Stereospecific Construction of Contiguous Quaternary All-Carbon Centers by Oxidative Ring Contraction

Oxidative ring contraction of cyclic α-formyl ketones was facilitated by the action of H2O2under operationally simple and environmentally benign reaction conditions. The process was highly regioselective and enables stereospecific construction of contiguous quaternary all-carbon centers from stereodefined all-substituted all-cyclic ketones. The asymmetric syntheses of (+)-cuparene and (+)-tochuinyl acetate were also successively achieved by taking advantage of this novel protocol.

First total synthesis and assignment of the stereochemistry of crispatenine

(Figure Presented) The first racemic and enantioselective synthesis of crispatenine 1 has been achieved, which involved a few steps, enabling the assignment of the absolute and relative configurations.

New Synthesis of γ-Homocyclogeranial, γ-Dihydroionone and Their Derivatives

A new and efficient synthesis of γ-homocyclogeranial (4), γ-dihydroionone (3) and their derivatives, 5, 6, 7 and 8, volatile components of ambergris, is described.Their compounds were synthesized via Claisen rearrangement of (3,3-dimethylcyclohexenyl)methyl vinyl ether (14).