613656-16-9

Basic information

• Product Name: 4-(2-CHLOROPHENOXY)BENZOIC ACID
• Synonyms: 4-(2-CHLOROPHENOXY)BENZOIC ACID
• CAS NO: 613656-16-9
• Molecular Formula: C₁₃H₉ClO₃
• Molecular Weight: 248.66
• Mol File: 613656-16-9.mol

Chemical Properties

• Boiling Point: 374.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.347±0.06 g/cm3(Predicted)
• PKA: 4.24±0.10(Predicted)
• CAS DataBase Reference: 4-(2-CHLOROPHENOXY)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-CHLOROPHENOXY)BENZOIC ACID(613656-16-9)
• EPA Substance Registry System: 4-(2-CHLOROPHENOXY)BENZOIC ACID(613656-16-9)

Safety Data

• Hazardous Substances Data: 613656-16-9(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Industry:
4-(2-Chlorophenoxy)benzoic acid is used as a herbicide for controlling broadleaf weeds in various crops such as soybeans, peanuts, and wheat. It is effective in inhibiting the growth of target weeds, leading to their death and ensuring the healthy growth of the desired crops.
Used in Weed Management:
4-(2-Chlorophenoxy)benzoic acid is used as a weed management tool to selectively control problematic weed species in agricultural fields. Its selective systemic action allows for targeted control of broadleaf weeds without causing significant harm to the surrounding crops.

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 158771-11-0 4-(2-chlorophenoxy)benzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 95-57-8 2-monochlorophenol 

Downstream Products

• 1377995-58-8 C₂₂H₂₇ClN₂O₂ 
• 913829-08-0 (5-{5-[4-(2-chlorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-4-ethyl-2-thienyl)methanol 

Relevant articles and documents

Design, synthesis, and biological evaluation of phenyloxadiazole derivatives as potential antifungal agents against phytopathogenic fungi

Abstract: A novel series of picarbutrazox-inspired oxadiazole hybrids was synthesized and the derivatives’ biological activity against phytopathogenic fungi was investigated. The molecules were designed by retaining the active fragment of tetrazolyl phenyloxime ether of lead compound picarbutrazox, while introducing the potentially active oxadiazole-derived fragment. Bioassay results revealed that some of the title compounds showed potent in vivo antifungal activities to control cucumber downy mildew. Therefore, this novel oxadiazole phenyloxadiazole derivative can be used as a potential antifungal agent to control cucumber downy mildew and other phytopathogenic fungi for crop protection. Graphic abstract: [Figure not available: see fulltext.].

Synthesis and structure–activity relationship of N-(piperidin-4-yl)benzamide derivatives as activators of hypoxia-inducible factor 1 pathways

Guided by bioisosterism and pharmacokinetic parameters, we designed and synthesized a series of novel benzamide derivatives. Preliminary in vitro studies indicated that compounds 10b and 10j show significant inhibitory bioactivity in HepG2 cells (IC50 values of 0.12 and 0.13?μM, respectively). Compounds 10b and 10j induced the expression of HIF-1α protein and downstream target gene p21, and upregulated the expression of cleaved caspase-3 to promote tumor cells apoptosis.

Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist

S1P3-sparing S1P1 agonists have attracted attention as a suppressant of autoimmunity with reduced side effects. Our synthetic efforts and extensive SAR studies led to the discovery of 10b named CS-2100 with the EC50 value of 4.0 nM for human S1P1 and over 5000-fold selectivity against S1P3. The in vivo immunosuppressive efficacy was evaluated in rats on host versus graft reaction and the ID 50 value was determined at 0.407 mg/kg. The docking studies of CS-2100 with the homology model of S1P1 and S1P3 showed that the ethyl group on the thiophene ring of CS-2100 was sterically hindered by Phe263 in S1P3, not in the case of Leu276 in S1P1. This observation gives an explanation for the excellent S1P3-sparing characteristic of CS-2100.

HETEROCYCLIC COMPOUND

[Object] To provide a novel compound having an excellent immunosuppressive activity with low toxicity or a pharmacological salt thereof. [Means to achieve the object] A compound having general formula (I) shown below or a pharmacologically acceptable salt thereof, or a pharmacologically acceptable prodrug thereof [wherein A represents a carboxyl group, or the like, B represents a hydrogen atom, or the like, V represents a single bond, a methylene group, or the like, n represents an integer of from 0 to 2, W represents a 5- to 7-membered heterocyclic group, or the like, Z represents a group selected from Substituent group A, or the like, and Substituent group A represents the group consisting of a halogen atom, a C1-C6 alkyl group, a C3-C7 cycloalkyl group.