- Synthesis of 6-phenylbenzo[h]quinolinesviaphotoinduced dehydrogenative annulation of (E)-2-phenyl-3-styrylpyridines
-
A concise and environmentally friendly protocol was developed for the synthesis of 6-phenylbenzo[h]quinolines. 6-Phenylbenzo[h]quinolines were obtained in good yieldsviairradiation of (E)-2-phenyl-3-styrylpyridines with a 254 nm UV light (64 W) in EtOH under an argon atmosphere in the presence of TFA. The reaction is a dehydrogenative annulation reaction that proceeds through 6π-electrocyclization, a [1,5]-H shift, 1,3-enamine tautomerization, and elimination of a hydrogen molecule to afford 6-phenylbenzo[h]quinolines. The described protocol not only avoids the usage of a transition metal catalyst and an oxidant but also has the advantages of high atom efficiency and mild reaction conditions.
- He, Yun,Liang, Yong,Niu, Lixin,Wang, Tao,Xi, Jin,Zhang, Zunting
-
supporting information
p. 8554 - 8558
(2021/10/20)
-
- With the antibacterial activity of the substituted 2 - amido - 1, 10 - eurepium (by machine translation)
-
The invention relates to a compound of formula I is shown of a substituted 2 - amido - 1, 10 - eurepium antibacterial compound or its physiologically acceptable salt and their method of preparation, also relates to a pharmaceutical composition comprising said compound. Wherein each substituent defined as stated in claims. (by machine translation)
- -
-
Paragraph 0037; 0038
(2019/06/07)
-
- Synthesis of stereodefined 1-aryl(heteroaryl) substituted 1,2-bis(2-bromopyridin-3-yl)ethenes by selective tandem Suzuki-Miyaura cross-coupling reactions
-
A protocol for the synthesis of stereodefined 1-aryl(heteroaryl) substituted 1,2-bis(2-bromopyridin-3-yl)ethenes by tandem Suzuki-Miyaura cross-coupling reactions and an example of convention into 5-phenyl-1,10-phenanthroline are described.
- Chelucci, Giorgio,Baldino, Salvatore
-
p. 2738 - 2742
(2008/09/18)
-
- Production method of a cross-coupling compound from an alkyl halide and an organoboron compound
-
There is provided a method for producing a coupling compound of formula (1):(Y-)(n-1)R1-R2-(R1)(n'-1) wherein R1, R2 n and n' are as defined below, Y is R2 or X as defined below, which method comprises reactinganorganichalogen compound of formula (2):n' (R1X1n) wherein X1 represents a bromine or iodine, R1 represents a substituted or unsubstituted, linear, branched or cyclic hydrocarbon group of which α and β carbon atoms in relation to X1 are sp3 carbon atoms, n and n' each independently represent an integer of 1 or 2, and provided that n and n' do not simultaneously represent 2, with an organic boron compound of formula (3):m{R2(BX22)n'} wherein R2 represents a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted alkenyl group and the boron atom is bonded with an sp2 carbon atom thereof, X2 represents a hydroxyl or alkoxy group, n' is as defined above, m represents an integer of 1 or 2, and m is not more than n, in the presence of a catalyst comprising a) a nickel compound, and ???b) b-1) a compound of formula (i): ???or ???b-2) a compound of formula (ii):
- -
-
-