61563-36-8

Basic information

• Product Name: 7,8-Dichloroisoquinoline
• Synonyms: 7,8-Dichloroisoquinoline;7,8-Dichloroisoquinoline 98%;7,8-Dichloroisoquinoline98%
• CAS NO: 61563-36-8
• Molecular Formula: C₉H₅Cl₂N
• Molecular Weight: 198.0487
• Product Categories: blocks;Heterocycles;Quinolines;Quinoline&Isoquinoline
• Mol File: 61563-36-8.mol

Chemical Properties

• Melting Point: 89-92
• Boiling Point: 327 °C at 760 mmHg
• Flash Point: 181.5 °C
• Appearance: /
• Density: 1.407 g/cm³
• Vapor Pressure: 0.000396mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 7,8-Dichloroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-Dichloroisoquinoline(61563-36-8)
• EPA Substance Registry System: 7,8-Dichloroisoquinoline(61563-36-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 61563-36-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
7,8-Dichloroisoquinoline is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with specific therapeutic or pesticidal properties, contributing to advancements in medicine and agriculture.
Used in Materials Science:
In the field of materials science, 7,8-Dichloroisoquinoline is explored for its potential applications due to its structural and electronic characteristics. It may be incorporated into the design of new materials with tailored properties for use in various industries.
Used in Organic Electronics:
7,8-Dichloroisoquinoline has also been studied for its possible use in organic electronics, where its electronic properties could be harnessed for the development of novel electronic devices and components.
It is crucial to handle 7,8-Dichloroisoquinoline with care, as it is toxic and should only be manipulated by trained professionals within a controlled laboratory environment to ensure safety and proper use.

InChI:InChI=1/C9H5Cl2N/c10-8-2-1-6-3-4-12-5-7(6)9(8)11/h1-5H

Upstream product

• 57987-75-4 2,3-dichloro-N-(2,2-dimethoxyethyl)benzylidenamine 
• 57987-75-4 N-<(2,3-dichlorophenyl)methylene>-2,2-dimethoxyethanamine 
• 6334-18-5 2,3-dichlorobenzylaldehyde 

Downstream Products

• 61563-24-4 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline 
• 57987-77-6 SKF 64139 hydrochloride 

Relevant articles and documents

Synthesis of novel substituted isoquinolones

A series of novel substituted isoquinolones have been synthesised. This has been achieved by two routes, either Curtius rearrangment of cinnamic acids or via an isoquinoline N-oxide.

Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis: I. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines

In a search for inhibitors of epinephrine biosynthesis as potential therapeutic agents, a series of 13 ring-chlorinated 1,2,3,4-tetrahydroisoquinolines was prepared. These compounds were tested initially for their ability to inhibit rabbit adrenal phenylethanolamine N-methyltransferase (PNMT) in vitro. Enzyme-inhibitor dissociation constants, determined for the six most potent members of the series, indicated the following order of decreasing potency: 7,8-Cl2>6,7,8-Cl3>7-Cl~8-Cl>5,6,7,8-Cl4>5,7,8-Cl3. These compounds were subsequently examined for PNMT-inhibiting activity in intact rats and mice. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SK&F 64139) was the most potent member of the series both in vitro and in vivo and is currently undergoing clinical investigation.

7 AND 8-Halo substituted 1,2,3,4-tetrahydroisoquinoline compounds

1,2,3,4-Tetrahydroisoquinoline compounds having 7 and 8 halo substituents are inhibitors of phenylethanolamine N-methyltransferase.

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.