6334-18-5Relevant articles and documents
An aerobic oxidation of alcohols into carbonyl synthons using bipyridyl-cinchona based palladium catalyst
Cheedarala, Ravi Kumar,Chidambaram, Ramasamy R.,Siva, Ayyanar,Song, Jung Il
, p. 32942 - 32954 (2021/12/02)
We have reported an aerobic oxidation of primary and secondary alcohols to respective aldehydes and ketones using a bipyridyl-cinchona alkaloid based palladium catalytic system (PdAc-5) using oxygen at moderate pressure. ThePdAc-5catalyst was analysed using SEM, EDAX, and XPS analysis. The above catalytic system is used in experiments for different oxidation systems which include different solvents, additives, and bases which are cheap, robust, non-toxic, and commercially available on the industrial bench. The obtained products are quite appreciable in both yield and selectivity (70-85%). In addition, numerous important studies, such as comparisons with various commercial catalysts, solvent systems, mixture of solvents, and catalyst mole%, were conducted usingPdAc-5. The synthetic strategy of oxidation of alcohol into carbonyl compounds was well established and all the products were analysed using1H NMR,13CNMR and GC-mass analyses.
Visible light mediated selective oxidation of alcohols and oxidative dehydrogenation of N-heterocycles using scalable and reusable La-doped NiWO4nanoparticles
Abinaya, R.,Balasubramaniam, K. K.,Baskar, B.,Divya, P.,Mani Rahulan, K.,Rahman, Abdul,Sridhar, R.,Srinath, S.
, p. 5990 - 6007 (2021/08/24)
Visible light-mediated selective and efficient oxidation of various primary/secondary benzyl alcohols to aldehydes/ketones and oxidative dehydrogenation (ODH) of partially saturated heterocycles using a scalable and reusable heterogeneous photoredox catalyst in aqueous medium are described. A systematic study led to a selective synthesis of aldehydes under an argon atmosphere while the ODH of partially saturated heterocycles under an oxygen atmosphere resulted in very good to excellent yields. The methodology is atom economical and exhibits excellent tolerance towards various functional groups, and broad substrate scope. Furthermore, a one-pot procedure was developed for the sequential oxidation of benzyl alcohols and heteroaryl carbinols followed by the Pictet-Spengler cyclization and then aromatization to obtain the β-carbolines in high isolated yields. This methodology was found to be suitable for scale up and reusability. To the best of our knowledge, this is the first report on the oxidation of structurally diverse aryl carbinols and ODH of partially saturated N-heterocycles using a recyclable and heterogeneous photoredox catalyst under environmentally friendly conditions.
Degradation of substituted phenols with different oxygen sources catalyzed by Co(II) and Cu(II) phthalocyanine complexes
Saka, Ece Tugba,Dügdü, Esra,ünver, Yasemin
, p. 1119 - 1130 (2019/05/17)
Research on substituted phenol degradations has received substantial attention. In this work, effective Co(II) and Cu(II) phthalocyanine complexes as catalysts were studied to degrade toxic phenols to harmless products. The effect of various process parameters, such as initial concentration of phenol, catalyst, oxygen sources, and temperature on the degradation reaction was investigated to achieve maximum degradation efficiency. The catalytic activities of Co(II) and Cu(II) phthalocyanines were evaluated for oxidation of phenolic compounds such as p-nitrophenol, o-chlorophenol, 2,3-dichlorophenol, and m-methoxyphenol. Co(II) phthalocyanine displayed good catalytic performance in degradation of 2,3-dichlorophenol to 2,3-dichlorobenzaldehyde and 2,3-dichloro-1,4-benzoquinone with the highest TON and TOF values within 3 h at 50 °C. The fate of catalyst during the degradation process was followed by UV–Vis spectroscopy.
A process for preparing 2, 3 - dichloro-benzaldehyde (by machine translation)
-
Paragraph 0034-0066, (2019/11/20)
The present invention provides a process for preparing 2, 3 - dichloro formaldehyde of the method, the method including: the 2, 3 - two chlorine animal pens fork two bromines solution, water and catalyst through the dynamic tubular reactor to carry out the hydrolysis reaction to obtain the 2, 3 - dichloro formaldehyde; the method of the invention, through the use of dynamic tubular reactor, using novel process route, hydrogen bromide as the hydrolysis catalyst, homogeneous phase hydrolysis the continuous preparation of 2, 3 - dichloro formaldehyde, compared with the traditional tank reactor and the like, has high mass transfer efficiency, good heat transfer efficiency, automatic precise control, high safety, shortens the reaction time, only needs 1 h can finish in about reaction, improves the reaction conversion and yield, is very suitable for industrial production. (by machine translation)
Method for synthesizing felodipine intermediate 2,3-dichlorobenzaldehyde
-
Paragraph 0030; 0036; 0037; 0043; 0044; 0051; 0052; 0053-007, (2019/10/01)
The invention discloses a method for synthesizing felodipine intermediate 2,3-dichlorobenzaldehyde. The method comprises the following steps: performing sulfonating, hydroformylation and de-sulfonation on o-dichlorobenzene to generate 2,3-dichlorobenzaldehyde; under the condition of a protonic acid, performing protonation and fracturing on urotropine to generate imine ions; using the imine ions toundergo electrophilic aromatic substitution on an aromatic ring and undergo tautomerism to generate a benzylamine derivative; performing secondary protonation and fracturing on the rest of urotropineto generate imine ions, and performing an intramolecular redox reaction to partially oxidize the benzylamine into benzylidene imine ions; and performing hydrolysis to obtain an aldehyde. The method has high selectivity, less pollution discharge and lower cost.
Method for preparing 2,3-dichlorobenzaldehyde through continuous oxidization of 2,3-dichlorotoluene
-
Paragraph 0039; 0040, (2017/07/12)
The invention relates to a method for preparing 2,3-dichlorobenzaldehyde through continuous oxidization of 2,3-dichlorotoluene, and belongs to the technical field of organic synthesis processes. The method comprises the following steps: taking 2,3-dichlorotoluene compound as a raw material, one or more metal ion complexes of cobalt, molybdenum and bromine is used as catalyst, hydrogen peroxide is used as an oxidizing agent, acetic acid is used as a solvent, and 2,3-dichlorotoluene is continuously oxidized in a tubular reactor to prepare the 2,3-dichlorobenzaldehyde. The method is mild in condition, short in reaction time and high in raw material utilization rate, effective control in the reaction process can be realized, safety and stability are achieved, continuous operation is achieved, and production efficiency is high.
Synthetic process of 2,3-dichlorobenzaldehyde
-
, (2017/09/01)
The invention discloses a synthetic process of 2,3-dichlorobenzaldehyde. The synthetic process comprises the steps that 2,3-dichlorotoluene is used as a raw material, bromine is used as an auxiliary material, azodiisobutyronitrile is used as a catalyst, the bromine utilization rate is improved through hydrogen peroxide, the generated 2,3-dichlorobenzyl bromide is hydrolyzed into 2,3-dichlorobenzaldehyde in 30 wt% of sodium carbonate water solution, the 2,3-dichlorobenzaldehyde is generated by using hydrogen bromide to catalyze hydrogen peroxide oxidization, the total yield is 70% or above, and the product purity is 99.25% or above. The raw material conversion rate and selectivity of the process are high. In addition, the by-product production rate is reduced, the bromine utilization rate is improved, the bromine usage amount is decreased, and the synthetic process is greener and environmentally friendly compared with a traditional metal-catalyzed oxidation technology.
Metal-free, visible-light photoredox catalysis: Transformation of arylmethyl bromides to alcohols and aldehydes
Li, Jian,Wang, Hongni,Liu, Li,Sun, Jiangtao
, p. 49974 - 49978 (2014/12/10)
A mild, simple, and controllable metal-free photocatalytic system for the transformation of arylmethyl bromides to corresponding alcohols and aldehydes in high yields with visible-light irradiation has been achieved. Eosin Y was found to be an efficient promoter for this oxidative dehalogenation reaction under photo irradiation conditions.
Solvent-controlled copper-catalyzed oxidation of benzylic alcohols to aldehydes and esters
Zhu, Yefeng,Wei, Yunyang
supporting information, p. 4503 - 4508 (2013/07/26)
A procedure for the copper-catalyzed selective oxidation of primary alcohols to esters and aldehydes was developed. Under solvent-free conditions, self-oxidative esterification and cross-esterification of benzyl alcohols with various aliphatic alcohols proceed smoothly to give the corresponding esters in good yields. If DMF was used as a solvent, the benzyl alcohols were selectively converted into the corresponding aldehydes in excellent yields. Depend on solvent! Under solvent-free conditions, Cu-catalyzed oxidative self-esterification and cross-esterification of benzylic alcohols with various aliphatic alcohols proceed smoothly to give the corresponding esters in good yields. If DMF is used as a solvent, the benzylic alcohols are selectively converted into the corresponding aldehydes in excellent yields. DTBP = di-tert-butyl peroxide. Copyright
Simple, economical and environmentally benign selective regeneration of carbonyl compounds from oximes and N,N-dimethyl hydrazones
Bose, D. Subhas,Reddy, A. V. Narsimha,Das, A. P. Rudra
, p. 1883 - 1885 (2007/10/03)
A mild, efficient, selective method for the regeneration of carbonyl compounds from oximes and N,N-dimethylhydrazones in MeCN at ambient temperature or aqueous media has been carried out in excellent yields under K 5CoW12O40·3H2O (0.01 equiv) catalysis.
