NOVEL COMPOUNDS WITH A 3A-AZABICYCLO [4.1.0] HEPTANE CORE ACTING ON OREXIN RECEPTORS
This invention relates to azabicyclo[4.1.0]hept-4-yl derivatives and their use as pharmaceuticals.
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Page/Page column 46
(2012/07/14)
Piperazinylpyrazines with central serotoninmimetic activity.
A series of 2-(1-piperazinyl)pyrazines was synthesized and evaluated for central serotonin-like activity. The most interesting member of the series, 6-chloro-2(1-piperazinyl)pyrazine (3a), had pharmacological properties characteristic of potent central serotoninmimetic activity and only weak peripheral serotoninmimetic action. Structural similarities between 3a and serotonin are discussed.
Lumma et al.
p. 536,538
(2007/10/04)
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