617716-32-2Relevant articles and documents
First dual M3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives
Provins, Laurent,Christophe, Bernard,Danhaive, Pierre,Dulieu, Jacques,Durieu, Véronique,Gillard, Michel,Lebon, Florence,Lengelé, Sébastien,Quéré, Luc,Van Keulen, Berendjan
, p. 1834 - 1839 (2007/10/03)
SAR around 4,6-diaminopyrimidine derivatives allowed the discovery of the first potent dual M3 antagonists and PDE4 inhibitors. Various chemical modulations around that scaffold led to the discovery of ucb-101333-3 which is characterized by the
CHEMICAL COMPOUNDS WITH DUAL ACTIVITY, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS
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Page/Page column 32-33, (2008/06/13)
The present invention concerns chemical compounds combining affinity and antagonism against the human m3 muscarinic receptor with activity as selective phosphodiesterase IV (PDE IV) inhibitors, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.