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Benzoic acid, 4-(4-pyridinyl)-, hydrazide (9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 619328-60-8 Structure
  • Basic information

    1. Product Name: Benzoic acid, 4-(4-pyridinyl)-, hydrazide (9CI)
    2. Synonyms: Benzoic acid, 4-(4-pyridinyl)-, hydrazide (9CI);4-(pyridin-4-yl)benzohydrazide
    3. CAS NO:619328-60-8
    4. Molecular Formula: C12H11N3O
    5. Molecular Weight: 213.23524
    6. EINECS: N/A
    7. Product Categories: HYDRAZINE
    8. Mol File: 619328-60-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Benzoic acid, 4-(4-pyridinyl)-, hydrazide (9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: Benzoic acid, 4-(4-pyridinyl)-, hydrazide (9CI)(619328-60-8)
    11. EPA Substance Registry System: Benzoic acid, 4-(4-pyridinyl)-, hydrazide (9CI)(619328-60-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 619328-60-8(Hazardous Substances Data)

619328-60-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 619328-60-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,9,3,2 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 619328-60:
(8*6)+(7*1)+(6*9)+(5*3)+(4*2)+(3*8)+(2*6)+(1*0)=168
168 % 10 = 8
So 619328-60-8 is a valid CAS Registry Number.

619328-60-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(pyridin-4-yl)benzohydrazide

1.2 Other means of identification

Product number -
Other names 4-(4-pyridinyl)benzohydrazide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:619328-60-8 SDS

619328-60-8Relevant articles and documents

Acylhydrazone as a novel off-On-Off fluorescence probe for the sequential detection of Al3+ and F-

Wu, Yi-Peng,Rahman, Faiz-Ur,Bhatti, Muhammad Zeeshan,Yu, Shang-Bo,Yang, Bo,Wang, Hui,Li, Zhan-Ting,Zhang, Dan-Wei

supporting information, p. 14978 - 14985 (2018/09/29)

A new acylhydrazone fluorescence probe, SPBH, was synthesized from salicylaldehyde and 4-(pyridin-4-yl)benzohydrazide (PBH). SPBH exhibited high selectivity and a sensitive fluorescence response towards Al3+, even in the presence of other competing metal ions in DMF/H2O (1:1, v/v) medium. And, the chemosensor can even detect Al3+ in the intracellular region of human non-small cell lung cancer H460 cells. The binding phenomenon of SPBH was investigated by 1H NMR spectroscopy and HR-MS. Mass spectrometry analysis showed a 1:1 complex formation of SPBH with Al3+. The Job plot also confirmed its 1:1 interaction. This SPBH/Al3+ complex exhibited excellent fluorescence turn-off properties towards the F- anion. Thus, SPBH acts as a sequential fluorescence Off-On-Off probe. The limits of detection for Al3+ and F- were calculated from the titration curve and found to be 1.1 × 10-7 M and 1.47 × 10-6 M, respectively.

Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate

Wu, Jiahui,Zhang, Dengyou,Chen, Lei,Li, Jianneng,Wang, Jianling,Ning, Chengqing,Yu, Niefang,Zhao, Fei,Chen, Dongying,Chen, Xiaoyan,Chen, Kaixian,Jiang, Hualiang,Liu, Hong,Liu, Dongxiang

, p. 761 - 780 (2013/04/10)

SIRT1 is an NAD+-dependent deacetylase, whose activators have potential therapeutic applications in age-related diseases. Here we report a new class of SIRT1 activators. The activation is dependent on the fluorophore labeled to the substrate. To elucidate the activation mechanism, we solved the crystal structure of SIRT3/ac-RHKKac-AMC complex. The structure revealed that the fluorophore blocked the H-bond formation and created a cavity between the substrate and the Rossmann fold. We built the SIRT1/ac-RHKK ac-AMC complex model based on the crystal structure. Km and Kd determinations demonstrated that the fluorophore decreased the peptide binding affinity. The binding modes of SIRT1 activators indicated that a portion of the activators interacts with the fluorophore through π-stacking, while the other portion inserts into the cavity or interacts with the Rossmann fold, thus increasing the substrate affinity. Our study provides new insights into the mechanism of SIRT1 activation and may aid the design of novel SIRT1 activators.

5-ARYL-1,3,4-OXADIAZOLE-2-AMINES AS NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS

-

Page/Page column 28, (2009/07/17)

The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and their use in the treatment of neurological, psychiatric disorders and gastrointestinal disorders. wherein R1 and R2 independently represent hydrogen, C1-6 alkyl or C3-6 cycloalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a nitroge containing heterocyclyl group which is unsubstituted or substituted with 1, 2, or 3 substituents selected from methyl or fluoro; Q represents -(CH2)n- wherein n represents 3 or 4; A represents a phenyl ring and B represents a 5 or 6 membered heteroaryl ring or B represents a phenyl ring and A represents a 5 or 6 membered heteroaryl ring; R3 and R4 independently represent C1-6 alkyl, C1-6 alkoxy and halo; t and m independently represent an integer from 0 to 3. Compounds of formula (I) and their pharmaceutically acceptable salts may have affinity for and be agonists at the nicotinic α7 receptor and are believed to be of potential use in the treatment of neurological diseases including Alzheimer's disease.

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