106047-17-0

Basic information

• Product Name: METHYL 4-(4-PYRIDINYL)BENZOATE
• Synonyms: METHYL 4-PYRIDIN-4-YL-BENZATE;METHYL 4-(PYRIDIN-4-YL)BENZOATE;METHYL 4-(4-PYRIDINYL)BENZOATE;AKOS BAR-0605;Methyl 4-(pyridin-4-yl)benoate
• CAS NO: 106047-17-0
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.23
• Mol File: 106047-17-0.mol
• Article Data: 23

Chemical Properties

• Melting Point: 103-105℃
• Boiling Point: 160 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.147
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.98±0.10(Predicted)
• CAS DataBase Reference: METHYL 4-(4-PYRIDINYL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-(4-PYRIDINYL)BENZOATE(106047-17-0)
• EPA Substance Registry System: METHYL 4-(4-PYRIDINYL)BENZOATE(106047-17-0)

Safety Data

• Hazardous Substances Data: 106047-17-0(Hazardous Substances Data)

Usage

General Description

Methyl 4-(4-pyridinyl)benzoate, also known as ethyl 4-(4-pyridyl)benzoate, is a chemical compound commonly used in the manufacturing of fragrances and flavorings. It is a yellow crystalline solid with a sweet, floral odor, and is often used as a component in perfumes and cosmetics. This chemical is also used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is important to note that methyl 4-(4-pyridinyl)benzoate is considered to be a low-toxicity compound, but direct contact with the skin or eyes should be avoided to prevent irritation.

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 93830-58-1 diethyl (pyridin-4-yl)borane 
• 100-43-6 4-vinylpyridine 
• 6018-41-3 methyl coumalate 
• 17763-71-2 4-carbomethoxyphenyl triflate 
• 1692-15-5 4-pyridylboronic acid 
• 110-86-1 pyridine 
• 1008-89-5 2-phenylpyridine 
• 1120-87-2 4-bromopyridin 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 626-64-2 pyridin-4-ol 
• 905966-40-7 methyl 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate 
• 626-61-9 4-Chloropyridine 
• 619-44-3 methyl 4-iodobenzoate 

Downstream Products

• 281235-04-9 methyl 4-(piperidine-4-yl)benzoate 
• 4385-76-6 4-(4-pyridinyl)benzoic acid 
• 355379-05-4 4-(4-methoxycarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 936130-82-4 methyl 4-(piperidine-4-yl)benzoate hydrochloride 
• 1421511-76-3 N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-4-(pyridin-4-yl)benzohydrazide 
• 619328-60-8 4-(pyridin-4-yl)benzohydrazide 

Relevant articles and documents

Upgrading malic acid to bio-based benzoates via a Diels-Alder-initiated sequence with the methyl coumalate platform

The conversion of naturally-occurring malic acid to the 2-pyrone methyl coumalate was optimized using a variety of acid catalysts. Coupling methyl coumalate with electron-rich dienophiles in an inverse electron-demand Diels-Alder (IEDDA)/decarboxylation/elimination domino sequence resulted in an investigation of the scope and limitations of the methodology. The thermal, metal-free, and one-pot procedure allows regioselective access to diverse aromatic compounds including tricyclic, biphenyl, and pyridinyl systems for elaboration. A comparison with analogous pyrones demonstrates the striking efficacy of methyl coumalate as a versatile platform for the generation of biorenewable functionalized benzoates. This journal is

A convenient synthesis of methyl 4-substituted benzoates via Diels-Alder reaction in the presence of palladium on activated carbon

The thermal reaction of methyl 2-oxo-2H-pyran-5-carboxylates with substituted styrenes in the presence of 10% palladium on activated carbon afforded directly the corresponding methyl 4-biphenylcarboxylates in good yields. By the similar procedure, methyl 4-heteroaryl- and 4-alkyl-substituted benzoates were obtained from heteroaromatic olefines and alkenes, respectively.

Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts

Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.

PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST

The present invention relates to a pyrrolopyrimidine compound as TLR7 agonist, and particularly relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, a preparation process thereof, a pharmaceutical composition containing such compounds and use thereof for manufacturing a medicament against viral infection.