6195-54-6

Basic information

• Product Name: DiosMin Octaacetate
• Synonyms: DiosMin Octaacetate
• CAS NO: 6195-54-6
• Molecular Formula: C₄₄H₄₈O₂₃
• Molecular Weight: 944.84
• Product Categories: Aromatics, Oligosaccharides, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 6195-54-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DiosMin Octaacetate(CAS DataBase Reference)
• NIST Chemistry Reference: DiosMin Octaacetate(6195-54-6)
• EPA Substance Registry System: DiosMin Octaacetate(6195-54-6)

Safety Data

• Hazardous Substances Data: 6195-54-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
DiosMin Octaacetate is used as a key intermediate in the synthesis of Diosmin derivatives for their potential therapeutic applications. Diosmin and its derivatives have been found to possess various biological activities, such as anti-inflammatory, antioxidant, and vasodilatory effects, making them valuable in the development of pharmaceutical products for treating various diseases and conditions.
Used in Drug Synthesis:
DiosMin Octaacetate is used as a starting material in the synthesis of various Diosmin derivatives, which can be further modified or combined with other compounds to create new drugs with improved properties or novel therapeutic effects. This allows researchers and pharmaceutical companies to explore and develop new drug candidates with potential applications in various medical fields.

Upstream product

• 108-24-7 acetic anhydride 
• 520-26-3 hesperidin 
• 520-27-4 diosmin 

Downstream Products

• 827346-24-7 3-bromo-octaacetyldiosmin 
• 827346-30-5 3-bromodiosmetin 
• 890661-60-6 3-bromodiosmetin 7-isopropyl ether 
• 890661-62-8 3-bromodiosmetin 7,3'-dibenzyl ether 
• 890661-71-9 3-(3'',4'',5''-trimethoxyphenyl)diosmetin 7-isopropyl ether 
• 890661-67-3 3-(3'',4'',5''-trimethoxyphenyl)diosmetin 3'-benzyl-5-methyl ether 
• 890661-66-2 3-(3'',4'',5''-trimethoxyphenyl)diosmetin 7,3'-dibenzyl-5-methyl ether 
• 890661-65-1 3-(3'',4'',5''-trimethoxyphenyl)diosmetin 7,3'-dibenzyl ether 
• 1415983-00-4 3-bromo-2-methoxyoctacetylhesperidin 
• 827346-25-8 3-chlorooctacetyldiosmin 
• 827346-33-8 C₂₈H₃₁ClO₁₅ 

Relevant articles and documents

Synthesis of 5-Hydroxy-3′,4′,7-trimethoxyflavone and Related Compounds and Elucidation of Their Reversal Effects on BCRP/ABCG2-Mediated Anticancer Drug Resistance

3′,4′,7-Trimethoxyflavone (TMF) has been reported to show a potent reversal effect on drug resistance mediated by breast cancer resistance protein (BCRP)/ATP-binding cassette subfamily G member 2 (ABCG2). In this study, we designed and synthesized five derivatives with either a hydroxy group or a fluorine atom at C-5 and several kinds of capping moiety at the C-7 hydroxy group, on the same 3′,4′-dimethoxy-substituted flavone skeleton. We subsequently evaluated the efficacies of these compounds against BCRP-expressing human leukaemia K562/BCRP cells. Reversal of drug resistance was expressed as the concentration of compound causing a twofold reduction in drug sensitivity (RI50). Of the synthesized compounds, the reversal effect of 5-hydroxy-3′,4′,7-trimethoxyflavone (HTMF, RI50 7.2 nm) towards 7-ethyl-10-hydroxycamptothecin (SN-38) was stronger than that of TMF (RI50 18 nm). Fluoro-substituted 5-fluoro-3′,4′,7-trimethoxyflavone (FTMF, RI50 25 nm) and monoglycosylated 7-(β-glucosyloxy)-5-hydroxy-3′,4′-dimethoxyflavone (GOHDMF, 91 nm) also exhibited reversal effects, whereas the di- and triglycoside derivatives did not. TMF, HTMF and FTMF at 0.01–10 μm upregulated the K562/BCRP cellular accumulation of Hoechst 33342 nuclear staining dye. In addition, western blotting revealed that treatment of K562/BCRP cells with 0.1 μm TMF, HTMF or FTMT suppressed the expression of BCRP. HTMF showed the strongest inhibition of BCRP-mediated efflux and suppression of BCRP expression of the three effective synthesized flavones.

Synthesis of new glycosylated flavonoids with inhibitory activity on cell growth

Natural flavonoids and xanthone glycosides display several biological activities, with the glycoside moiety playing an important role in the mechanism of action of these metabolites. Herein, to give further insights into the inhibitory activity on cell gr

Synthesis and anti-tubulin evaluation of chromone-based analogues of combretastatins

Twenty new hybrid compounds with both combretastatin and flavone moieties were synthesized. These derivatives are classified according to the position of the trimethoxyphenyl ring at C-2 or C-3 of the chromone and presence or absence of a carbonyl as a linker between C-3 and the aryl ring. Most of these compounds were prepared from hesperidin or naringin, two natural and abundant Citrus flavonoids. Seven of these combretastatin analogues revealed anti-tubulin activity but in a medium range.