62182-11-0 Usage
Uses
Used in Medical Imaging:
4-Fluoro-4-deoxy-D-glucose is used as a PET radiopharmaceutical for visualizing and locating areas of increased metabolic activity in the body. It serves as a marker for conditions with high glucose metabolism, such as cancer, heart disease, and neurological disorders.
Used in Cancer Diagnosis and Monitoring:
In the field of oncology, 4-Fluoro-4-deoxy-D-glucose is used as a diagnostic and monitoring tool for cancer. It helps physicians detect the presence of tumors, assess their metabolic activity, and evaluate the effectiveness of treatments by observing changes in glucose uptake.
Used in Heart Disease Detection:
4-Fluoro-4-deoxy-D-glucose is utilized in cardiology to identify areas of the heart with reduced blood flow or damaged tissue, which may indicate heart disease. By visualizing the metabolic activity of heart tissue, physicians can better understand the extent of the disease and determine appropriate treatment strategies.
Used in Neurological Disorder Assessment:
In neurology, 4-Fluoro-4-deoxy-D-glucose is employed to assess metabolic changes in the brain associated with various neurological disorders. PET imaging with 18F-FDG can reveal areas of abnormal glucose metabolism, aiding in the diagnosis and monitoring of conditions such as Alzheimer's disease, Parkinson's disease, and epilepsy.
Check Digit Verification of cas no
The CAS Registry Mumber 62182-11-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,1,8 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 62182-11:
(7*6)+(6*2)+(5*1)+(4*8)+(3*2)+(2*1)+(1*1)=100
100 % 10 = 0
So 62182-11-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H11FO5/c7-3-2(1-8)12-6(11)5(10)4(3)9/h2-6,8-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
62182-11-0Relevant articles and documents
Addressing the Structural Complexity of Fluorinated Glucose Analogues: Insight into Lipophilicities and Solvation Effects
St-Gelais, Jacob,C?té, émilie,Lainé, Danny,Johnson, Paul A.,Giguère, Denis
supporting information, p. 13499 - 13506 (2020/10/02)
In this work, we synthesized all mono-, di-, and trifluorinated glucopyranose analogues at positions C-2, C-3, C-4, and C-6. This systematic investigation allowed us to perform direct comparison of 19F resonances of fluorinated glucose analogues and also to determine their lipophilicities. Compounds with a fluorine atom at C-6 are usually the most hydrophilic, whereas those with vicinal polyfluorinated motifs are the most lipophilic. Finally, the solvation energies of fluorinated glucose analogues were assessed for the first time by using density functional theory. This method allowed the log P prediction of fluoroglucose analogues, which was comparable to the C log P values obtained from various web-based programs.
THE SYNTHESIS AND HYDROLYSIS OF A SERIES OF DEOXYFLUORO-D-GLUCOPYRANOSYL PHOSPHATES
Withers, Stephen G.,MacLennan, David J.,Street, Ian P.
, p. 127 - 144 (2007/10/02)
The synthesis of all four deoxyfluoro-α-D-glucopyranosyl phosphates is described.Rate conctants for their acid-catalyzed hydrolysis were determined, and fluorine substitution was shown to have a significant effect in lowering the rate, particularly when t
