Diprotonative stabilization of ring-opened carbocationic intermediates: conversion of tetrahydroisoquinoline to triarylmethanes
Superacid-promoted conversion of tetrahydroisoquinolines to triarylmethanes via tandem reactions of C-N bond scission, Friedel-Crafts alkylation, C-O bond scission, and electrophilic aromatic amidation was developed. Dication formation was important for stabilizing the ring-opened carbocationic intermediate, which is a new role for diprotonation in reaction mechanisms. This journal is
Kurouchi, Hiroaki
p. 8313 - 8316
(2020/08/17)
Asymmetric Transfer Hydrogenation of Unhindered and Non-Electron-Rich 1-Aryl Dihydroisoquinolines with High Enantioselectivity
The use of arene/Ru/TsDPEN catalysts bearing a heterocyclic group on the TsDPEN in the asymmetric transfer hydrogenation (ATH) of dihydroisoquinolines (DHIQs) containing meta- or para-substituted aromatic groups at the 1-position results in the formation of products of high enantiomeric excess. Previously, only 1-(ortho-substituted)aryl DHIQs, or with an electron-rich fused ring gave products with high enantioselectivity; therefore, this approach solves a long-standing challenge for imine ATH.
Barrios-Rivera, Jonathan,Xu, Yingjian,Wills, Martin
p. 6283 - 6287
(2020/09/02)
Highly-efficiency red-emitting platinum (II) complexes containing 4′-diarylamino-1-phenylisoquinoline ligands in polymer light-emitting diodes: Synthesis, structure, photoelectron and electroluminescence
Heteroleptic cyclometalated platinum (II) complexes bearing diarylamino-functionalized 1-phenylisoquinoline derivatives as primary ligand and acetyl acetonate as ancillary ligand were prepared and characterized. Single-crystal X-ray diffraction revealed t
(Dihydro) Isoquinoline derivatives as phosphodiesterase inhibitors
3,4-Dihydroisoquinoline and isoquinoline compounds of formula I, in which Ar represents a phenyl raidcal of the formulae IIa, IIb or IIc are novel effective PDE7 inhibitors.
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(2008/06/13)
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