- PYRIDINE COMPOUNDS AND USES THEREOF
-
The present invention is directed to pyridine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psych
- -
-
Page/Page column 17; 18
(2013/03/26)
-
- Preparation of substituted 1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-ones
-
A new synthetic route to 6-substituted-imidazo[4,5-c]pyridin-2-ons from 4-aminopyridine has been investigated. 4-Aminopyridine protected as alkyl carbamates were nitrated with dinitrogen pentoxide to the corresponding methyl, i-propyl and t-butyl 3-nitropyridin-4-yl carbamates (5a-c) in 51-63% yields. Attempts to substitute these in the 6-position by the ONSH and the VNS techniques succeeded with butylamine and the t-butyl carbamate 9. From the methyl or t-butyl 3-nitropyridin-4-yl carbamates 5a, 5c 1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (1) was formed in 73 and 39% yields, respectively. t-Butyl 6-N-butylamin-3-aminopyridin-4-yl carbamate (6) gave 6-butylamino-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (7) in 53% yield.
- Bakke, Jan M.,Gautun, Hanna S. H.,Svensen, Harald
-
p. 585 - 591
(2007/10/03)
-