623564-72-7

Basic information

• Product Name: 5H,7H-Imidazo[1,2-c]thiazole-2-carboxaldehyde (9CI)
• Synonyms: 5H,7H-Imidazo[1,2-c]thiazole-2-carboxaldehyde (9CI);5H,7H-Imidazo[1,2-c]thiazole-2-carboxaldehyde
• CAS NO: 623564-72-7
• Molecular Formula: C6H6N2OS
• Molecular Weight: 154.18964
• Product Categories: AMINETERTIARY;ALDEHYDE
• Mol File: 623564-72-7.mol

Chemical Properties

• Boiling Point: 436.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.55±0.1 g/cm3(Predicted)
• PKA: 3.05±0.20(Predicted)
• CAS DataBase Reference: 5H,7H-Imidazo[1,2-c]thiazole-2-carboxaldehyde (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5H,7H-Imidazo[1,2-c]thiazole-2-carboxaldehyde (9CI)(623564-72-7)
• EPA Substance Registry System: 5H,7H-Imidazo[1,2-c]thiazole-2-carboxaldehyde (9CI)(623564-72-7)

Safety Data

• Hazardous Substances Data: 623564-72-7(Hazardous Substances Data)

Upstream product

• 623564-71-6 thiazolidin-4-ylideneamine 
• 19263-02-6 2-bromo-3-hydroxypropenal 
• 155272-73-4 2-bromo-3-(1-methylethoxy)-2-propenal 

Relevant articles and documents

Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors

This invention relates to certain bicyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with β-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of general formula I or a pharmaceutically acceptable salt or in vivo hydrolyzable ester R5 thereof: wherein: One of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X═O or S.

Process for preparing 6-alkylidene penem derivatives

The present invention provides a process of making compounds of formula I, which are useful for the treatment of bacterial infection or disease.

BICYCLIC 6-ALKYLIDENE-PENEMS AS ?-LACTAMASES INHIBITORS

The present invention provides a compound of Formula (I), pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.

PROCESS FOR PREPARING 6-ALKYLIDENE PENEM DERIVATIVES

The present invention provides a process of making compounds of Formula (I), which are useful for the treatment of bacterial infection or disease.