623577-59-3 Usage
Uses
Used in Pharmaceutical Industry:
4-BROMO-1-(4-FLUORO-PHENYL)-1H-IMIDAZOLE is used as a building block and intermediate for the production of pharmaceuticals, contributing to the development of new drugs and medical treatments due to its pharmacological properties.
Used in Agrochemical Industry:
4-BROMO-1-(4-FLUORO-PHENYL)-1H-IMIDAZOLE is also utilized as an intermediate in the synthesis of agrochemicals, playing a role in the development of pesticides and other agricultural products to protect crops and enhance yields.
Used in Organic Synthesis:
4-BROMO-1-(4-FLUORO-PHENYL)-1H-IMIDAZOLE is used as a key component in organic synthesis, serving as a versatile building block for the creation of various fine chemicals that have a range of applications across different industries.
Used as a Reagent in Chemical Reactions:
In the field of chemistry, 4-BROMO-1-(4-FLUORO-PHENYL)-1H-IMIDAZOLE is employed as a reagent in specific chemical reactions such as Suzuki coupling and Sonogashira cross-coupling, facilitating the formation of new chemical bonds and the synthesis of complex molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 623577-59-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,3,5,7 and 7 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 623577-59:
(8*6)+(7*2)+(6*3)+(5*5)+(4*7)+(3*7)+(2*5)+(1*9)=173
173 % 10 = 3
So 623577-59-3 is a valid CAS Registry Number.
623577-59-3Relevant articles and documents
Novel orally bioavailable γ-secretase inhibitors with excellent in vivo activity
Keown, Linda E.,Collins, Ian,Cooper, Laura C.,Harrison, Timothy,Madin, Andrew,Mistry, Jayesh,Reilly, Michael,Shaimi, Mohamed,Welch, Christopher J.,Clarke, Earl E.,Lewis, Huw D.,Wrigley, Jonathan D. J.,Best, Jonathan D.,Murray, Fraser,Shearman, Mark S.
supporting information; experimental part, p. 3441 - 3444 (2010/03/30)
The development of potent γ-secretase inhibitors having substituted heterocycles attached to a benzobicyclo[4.2.1]nonane core is described. This work led to the identification of [6S,9R,11R]-2′,3′,4′,5, 5′,6,7,8,9,10-decahydro-2-(5-(4-fluorophenyl)-1-methylpyrazol-3-yl) -5′-(2,2,2-trifluoroethyl)spiro[6,9-methanobenzocyclooctene-11, 3′-[1,2,5]thiadiazole] 1′,1′-dioxide (16), which has excellent in vitro potency (0.06 nM) and which reduced amyloid-β in APP-YAC mice with an ED50 of 1 mg/kg (po). 16 had a good pharmacokinetic profile in three preclinical species.
HETEROARYL SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR INHIBITION OF GAMMA SECRETASE
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Page/Page column 111, (2008/06/13)
Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
