- Synthesis and characterization of [Mo3S4(NDABu) (HNDABu)2]3- and [Mo3S4(HNDAPr) 3]2- anions as building blocks for organic-inorganic hybrid solids
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The polymetallic cation [Mo3S4(H2O) 9]4+ was used as an inorganic precursor to generate new hybrid organic-inorganic chalcogenide clusters. Three organic compounds with flexible and hanging arms were synthesized and investigated as ligands for coordination complexes with the rigid and electroactive inorganic {Mo 3S4} unit. Interestingly, the {Mo3S 4} core formed hybrid structures with the flexible H3NDABu [N-(3-carboxypropyl)iminodiacetic acid] and H3NDAPr [N-(2-carboxyethyl)iminodiacetic acid] ligands, which were characterized by X-ray crystallography. Surprisingly, no crystals were isolated, when the more rigid H3NDABn [N-(4-methoxycarbonylbenzyl)iminodiacetic acid] ligand was used. The two coordination complexes [Mo3S4(NDABu) (HNDABu)2]3- and [Mo3S4(HNDAPr) 3]2- were characterized by X-ray diffraction (XRD), IR spectroscopy, thermal gravimetric analysis (TGA), 1H NMR spectroscopy, elemental analysis, and electrochemistry. The organic ligands H3NDABu, H3NDAPr, and H3NDABn were characterized by XRD, IR, HR mass, and 13C and 1H NMR spectroscopy. [Mo3S4(NDABu)(HNDABu)2] 3- and [Mo3S4(HNDAPr)3]2- constitute promising preformed building blocks to generate new organic-inorganic hybrid molecular or extended materials. Two new promising preformed building blocks [Mo3S4(NDABu)(HNDABu) 2]3- and [Mo3S4(HNDAPr) 3]2- have been obtained. Their syntheses and characterizations are described. Copyright
- Duval, Sylvain,Dumur, Frederic,Guenee, Laure,Marrot, Jerome,Simonnet-Jegat, Corine,Cadot, Emmanuel
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p. 1149 - 1156
(2013/03/29)
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- Preparation of α-alaninediacetic acid or its alkali metal or ammonium salts
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The invention relates to a process for preparing β-alaninediacetic acid (Ia) or its alkali metal or ammonium salts (Ib) which comprises reacting iminodiacetic acid with acrylonitrile or C1 -C4 -alkyl acrylates in weakly acid to weakly basic aqueous medium and subsequently hydrolyzing the nitrile or ester moiety to the acid or a salt. The products prepared according to the invention can be used, in particular, to form complexes.
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- Preparation of β-alaninediacetic acid or its alkali metal or ammonium salts
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β-Alaninediacetic acid (Ia) or its alkali metal or ammonium salts (Ib) are prepared by a process in which iminodiacetic acid and acrylic acid (a) for the preparation of Ia, are reacted with one another in a nonbasic aqueous medium and (b) for the preparation of Ib, are reacted with one another in an alkaline aqueous medium or an aqueous medium containing a nitrogen base, or the Ia formed in the nonbasic medium is converted with an alkali metal base, ammonia or an amine into Ib.
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- Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
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Disclosed herein are nasal spray compositions and methods for enhancing polypeptide absorption across nasal membranes comprising a chelating agent and a polypeptide in a pharmaceutically acceptable excipient.
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