- Chemical compounds
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Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
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- Synthesis of methyl 5(6)-(4-aminophenoxy)-and 5(6)-(2-aminophenoxy)-2- benzimidazolyl carbamates and their biological properties
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A procedure was developed for preparation of methyl 5(6)-(4-aminophenoxy)- and 5(6)-(2-aminophenoxy)-2-benzimidazolyl carbamates by reaction of 3,4,4′-triaminodiphenyl or 3,4,2′-triaminodiphenyl ethers respectively with methyl cyanocarbamate in water solution in the presence of 7-10 molar excess of acetic acid. The helminthicidal properties, embryotoxicity, and overall toxicity of compounds obtained were estimated.
- Pilyugin,Mikhailyuk,Kosareva,Chikisheva,Kiseleva,Kuznetsova,Vorobyeva,Klimakova
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p. 1154 - 1160
(2007/10/03)
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- Synthesis of 3,4,4′- and 2′,3,4-triaminodiphenyl ethers
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Procedures were developed for preparing 3,4,4′- and 2′,3,4-triaminodiphenyl ethers by the reaction of 4-acetylaminophenol with, respectively, 4-nitro- or 2-nitrochlorobenzene, followed by nitration of the resulting 4-acetylamino-4′- or -2′-nitrodiphenyl ether, hydrolysis of the product, 4-acetylamino-3,4′- or -2′,3- dinitrodiphenyl ether, and reduction of 4-amino-3,4′- or -2′-3-dinitrodiphenyl ether.
- Pilyugin,Mikhailyuk,Kiseleva,Kuznetsova,Chikisheva,Kosareva
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p. 1105 - 1109
(2007/10/03)
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