- Method for synthesizing gamma-chloro-butyric acid
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The invention provides a method for synthesizing gamma-chloro-butyric acid. The method comprises the following steps of adding 86g of gamma-butyrolactone into a flask; performing stirring at room temperature and normal pressure; adding 1 to 10 percent of heteropolyacid catalysts; performing stirring at room temperature and normal pressure; slowly dripping 200g of 20-percent hydrochloric acid; performing stirring reaction for 2h; through GC detection, the residue of gamma-butyrolactone is smaller than 1 percent; the content of the gamma-chloro-butyric acid reaches 99 percent or higher; still standing layering is performed; a lower layer product is collected; the upper layer water phase is repeatedly reused. An effective reaction catalyst is selected; high-pressure reaction is avoided; the danger due to the use of thionyl chloride is avoided; no waste water is generated in the reaction process; the catalyst can be repeatedly reused; the yield of the prepared gamma-chloro-butyric acid ishigh.
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Paragraph 0012; 0015-0020
(2019/02/17)
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- Process for treating homoserin compounds
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The present invention relates to the preparation of a useful compound which can be used as an intermediate product for preparing an important compound in the industrial field from a homoserine-based compound and provides a process for treating a homoserine-based compound, capable of simply mass producing a useful compound from a homoserine-based compound with excellent efficiency.(AA) Homoserine-based compound(BB) Product(CC) GBL derivative(DD) Halo-GBL(EE, FF, GG) GBL puranone(HH) Puranone(II) Dialkyl succinate(JJ) Step 1(KK) Step 2(LL) Step 3(MM) Step 4(NN) Step 5(OO) Step 6(PP) Step 7COPYRIGHT KIPO 2016
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Paragraph 0154-0158
(2017/01/02)
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- (P(C6H5)3)CpRu+-catalyzed deprotection of allyl carboxylic esters
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A new and efficient catalytic method for deprotection of allyl carboxylic esters using a transition metal complex is reported. The reaction proceeds with a high substrate/catalyst ratio and without use of additional nucleophiles, giving the deprotected carboxylic acid in a quantitative yield. A variety of substrates, including the multifunctional amino acids and peptides, are also usable. The new method is more efficient, safe, and operationally simple in comparison to the conventional palladium-catalyzed method.
- Kitamura, Masato,Tanaka, Shinji,Yoshimura, Masahiro
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p. 4975 - 4977
(2007/10/03)
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- Preparation of 4,4-dimethoxybutyl chloride from γ-butyrolactone
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4,4-Dimethoxybutyl chloride 4, an important alternate for the synthesis of 1,5- and 1,6-dicarbonyl functionalities, has been synthesized from γ-butyrolactone.
- Athar, Taimur
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p. 1037 - 1038
(2007/10/03)
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- 'Dry' hydrolysis of nitriles by sodium perborate and copper salts in heterogeneous media
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Nitriles react with sodium perborate or copper salts to yield carboxylic acids under mild acidic conditions. The multiphase reaction can be carried out in the absence of solvent, water, added acid or base. The yields are good, and the nitrile group can be hydrolysed in the presence of other functional groups. A comparative study between microwave and conventional heating shows that there is no specific activation from the electromagnetic field. However, careful attention to temperature and pressure measurements in the experimental apparatus is clearly needed.
- Chemat, Farid,Poux, Martine,Berlan, Jacques
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p. 1781 - 1784
(2007/10/03)
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- MODERN FRIEDEL-CRAFTS CHEMISTRY XVI. REACTION OF THIOPHENE WITH BIFUNCTIONAL MOLECULES UNDER DIFFERENT FRIEDEL-CRAFTS CATALYSTS: ATTEMPTED SYNTHESIS OF CYCLOPENTA THIOPHENES AND DIHYDROBENZO THIOPHENES
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The reaction of thiophene (1) with 3-chloropropionyl chloride (2), 4-chlorobutyryl chloride (3), crotonyl chloride (4) and cinnamoyl chloride (5) under different Friedel-Crafts catalysts (AlCl3/CH3NO2, FeCl3, and AlCl3/CS2) was investigated.The cyclic products 4,5-dihydro-6H-4-methylcyclopenta-thiophen-6-one, 5,6-dihydrobenzothiophen-7(4H)one and 4-phenyl-6H-cyclopentathiophen-6-one were formed.The different behaviors of compounds (2-5) towards thiophene were discussed.
- El-Khagawa, Ahmed M.,El-Zohry, Maher F.,Ismail, Mohamed T.
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- Gas-Phase Elimination Kinetics of Ethyl Esters of Chloroacetate, 3-Chloropropionate, and 4-Chlorobutyrate. The Electronic Effects of Substituents at the Acyl Carbon
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Several ethyl chloroesters were pyrolyzed in a static reactor in the presence of a propene inhibitor at temperatures between 360 and 420 deg C and pressures between 49 and 209 torr.The reactions are homogeneous, unimolecular, and follow a first-order rate law.The temperature dependence of the rate coefficients is given by the following Arrhenius equations: for ethyl chloroacetate, log k(s-1) = (12.70+/-0.50) - (197.0+/-6.1)kJ mol-1 (2.303RT)-1; for ethyl 3-chloropropionate, log k(s-1) = (12.54+/-0.22) - 196.8+/-2.7) kJ mol-1 (2.303RT)-1; and ethyl 4-chlorobutyrate, log k(s-1) = (12.67+/-0.31) - (198.7+/-3.8) kJ mol-1 (2.303RT)-1.The data from the rate coefficients give an approximate correlation only with ?* values (ρ*=0.357, r=0.903, and intercept =0.048 at 400 deg C).The present work together with those reported in the literature suggests, that electron-withdawing substituents at the acyl carbon of ethyl, isopropyl, and tert-butyl esters of substituted acetates enhance the rate of elimination, whereas electron-releasing substituents decrease it.
- Chuchani, Gabriel,Triana, Juana L.,Rotinov, Alexandra,Caraballo, Darlo F.
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p. 1243 - 1245
(2007/10/02)
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- A New Synthesis of Geranyl Acetate
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A new route to geranyl acetate starting from isohexenyl chloride (VIII) and 3,4-dichlorobutan-2-one (IX) is described.The route involves stereoselective reactions giving products with the desired configuration.Preparation of VIII by a new method is also described.
- Mathew, K. K.,Raman, P. S.,Antharjanam, T. G. Bhargavi
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p. 340 - 342
(2007/10/02)
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