- Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines
-
The first utility of ytterbium(0) as a mediating-metal in the intramolecular cyclization of brominated oxime ether was reported in this paper. In contrast to the prior methods, the N–O bond was used as a receptor of nucleophilic reagent, rather than as a source of N-centered radicals. Cyclic imines were obtained in this one-pot reaction with a broad scope of substrates and feasible reaction conditions.
- Wang, Yiqiong,Huang, Fei,Zhang, Songlin
-
supporting information
p. 5178 - 5181
(2020/08/13)
-
- Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process
-
In this study, we screened a large library of (+)-camphor and (?)-borneol derivatives to assess their filovirus entry inhibition activities using pseudotype systems. Structure-activity relationship studies revealed several compounds exhibiting submicromolar IC50 values. These compounds were evaluated for their effect against natural Ebola virus (EBOV) and Marburg virus. Compound 3b (As-358) exhibited the good antiviral potency (IC50 = 3.7 μM, SI = 118) against Marburg virus, while the hydrochloride salt of this compound 3b·HCl had a strong inhibitory effect against Ebola virus (IC50 = 9.1 μM, SI = 31) and good in vivo safety (LD50 > 1000 mg/kg). The results of molecular docking and in vitro mutagenesis analyses suggest that the synthesized compounds bind to the active binding site of EBOV glycoprotein similar to the known inhibitor toremifene.
- Baev, Dmitriy S.,Maksyutov, Rinat A.,Mordvinova, Ekaterina D.,Pyankov, Oleg V.,Salakhutdinov, Nariman F.,Shcherbakov, Dmitriy N.,Shcherbakova, Nadezhda S.,Sokolova, Anastasiya S.,Tolstikova, Tatyana G.,Yarovaya, Olga I.,Zaykovskaya, Anna V.,Zybkina, Anastasiya V.
-
-
- FGFR INHIBITOR AND APPLICATION THEREOF
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An azatricyclic compound (as represented by formula I) which acts as an inhibitor of fibroblast growth factor receptors (FGFR), as well as a pharmaceutical composition thereof, a preparation method, and a use therefor in the treatment of FGFR-mediated diseases. The azatricyclic compound exerts an effect by means of participating in the regulation of a plurality of processes such as cell proliferation, apoptosis, migration, neovascularization, and the like. AA%%%Formula (I).
- -
-
Paragraph 0249-0250
(2020/01/22)
-
- Method for long-term stable preparation of 4-chlorobutyryl chloride
-
The invention relates to a synthesis method of 4-chlorobutyryl chloride, which is characterized in that gamma-butyrolactone and di (trichloromethyl) carbonate are used as reaction raw materials, and aspecific amine catalyst is used for chlorination reaction to obtain the 4-chlorobutyryl chloride. Wherein the amine catalyst is an intercalation product obtained after aluminum dihydrogen tripolyphosphate reacts with a complex of organic amine and copper, and the structure is disclosed in the invention, and R is alkyl and aryl.
- -
-
Paragraph 0042-0068
(2020/08/27)
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- Iminyl Radicals by Reductive Cleavage of N-O Bond in Oxime Ether Promoted by SmI2: A Straightforward Synthesis of Five-Membered Cyclic Imines
-
A new generation method of N-centered radicals from the reductive cleavage of the N-O bond in oxime ether promoted by SmI2 is reported for the first time. The in-situ-generated N-centered radicals underwent intramolecular cyclization to afford five-membered cyclic imines in two manners: N-centered radical addition and N-centered anion nucleophilic substitution. From a synthetic point of view, an efficient synthetic method of five-membered cyclic imines was developed. A mechanism of the transformation was proposed.
- Huang, Fei,Zhang, Songlin
-
supporting information
p. 7430 - 7434
(2019/10/11)
-
- Synthesis of Piperidine Derivatives by Rhodium- Catalyzed Tandem Reaction of N-Sulfonyl-1,2,3-Triazole and Vinyl Ether
-
A chemoselective tandem reaction of 4-acyloxymethylene-1-sulfonyl-1,2,3-triazole and vinyl ether was reported, producing polysubstituted piperidine derivatives in up to 96% yield. The key intermediate N-sulfonyl 1-azadiene generated by migration of the OAc group to the α-imino rhodium carbene was isolated and a plausible mechanism was proposed. Several related ring systems were constructed from the highly functionalized products. (Figure presented.).
- Yu, Sisi,An, Yuehui,Wang, Wenlin,Xu, Ze-Feng,Li, Chuan-Ying
-
supporting information
p. 2125 - 2130
(2018/04/17)
-
- Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (?)-Borneol from Abies sibirica and (+)-Camphor
-
A series of the bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μm, respectively, and good cytotoxicity. The primary structure–activity relationship (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.
- Sokolova, Anastasiya S.,Yarovaya, Olga I.,Bormotov, Nikolay I.,Shishkina, Larisa N.,Salakhutdinov, Nariman F.
-
-
- Method for synthesizing 4-chlorobutyryl chloride
-
The invention relates to a method for synthesizing 4-chlorobutyryl chloride, which is characterized in that gamma-butyrolactone and di(trichloromethyl) carbonate are used as reaction raw materials, and a specific amine catalyst is used for carrying out chlorination reaction to obtain 4-chlorobutyryl chloride, wherein, the amine catalyst is an intercalation product obtained by reacting aluminum dihydrogen tripolyphosphate with an organic amine, and the structure thereof is as follows: the formulas are shown in the specification, wherein R is an alkyl group and an aromatic group.
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-
Paragraph 0035-0058
(2018/12/13)
-
- QUINAZOLINE DERIVATIVE
-
Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.
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-
Paragraph 0088
(2017/07/04)
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- Photoinduced, Copper-Catalyzed Decarboxylative C-N Coupling to Generate Protected Amines: An Alternative to the Curtius Rearrangement
-
The Curtius rearrangement is a classic, powerful method for converting carboxylic acids into protected amines, but its widespread use is impeded by safety issues (the need to handle azides). We have developed an alternative to the Curtius rearrangement that employs a copper catalyst in combination with blue-LED irradiation to achieve the decarboxylative coupling of aliphatic carboxylic acid derivatives (specifically, readily available N-hydroxyphthalimide esters) to afford protected amines under mild conditions. This C-N bond-forming process is compatible with a wide array of functional groups, including an alcohol, aldehyde, epoxide, indole, nitroalkane, and sulfide. Control reactions and mechanistic studies are consistent with the hypothesis that copper species are engaged in both the photochemistry and the key bond-forming step, which occurs through out-of-cage coupling of an alkyl radical.
- Zhao, Wei,Wurz, Ryan P.,Peters, Jonas C.,Fu, Gregory C.
-
supporting information
p. 12153 - 12156
(2017/09/12)
-
- N-(4-alkyl-5-benzylthiazol-2-yl)aminoalkylamide, and preparation method and application thereof
-
The invention relates to N-(4-alkyl-5-benzylthiazol-2-yl)aminoalkylamide with a chemical structural formula I as described in the specification or salts thereof. In the formula I, R is selected from a group consisting of C1-C2 alkyl groups, C3-C4 straight-chain alkyl groups and C3-C4 branched-chain alkyl groups; Y and Y are selected from a group consisting of hydrogen, a methyl group, an ethyl group, a hydroxyl group, a methoxy group, an ethoxy group, fluorine, chlorine, bromine and iodine; Y and Y are selected from a group consisting of hydrogen, a methyl group and an ethyl group; n is in a range of 1 to 9; and the salt is selected from a group consisting of hydrochloride, hydrobromide, sulfate, nitrate, phosphate, mesylate, benzene sulfonate, tosilate, malate, lactate, succinate, maleate and fumarate. The invention also discloses application of N-(4-alkyl-5-benzylthiazol-2-yl)aminoalkylamide or the salts thereof to preparation of anticancer drugs.
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-
Paragraph 0024; 0025
(2017/07/19)
-
- Overcoming Problems at Elaboration and Scale-up of Liquid-Phase Pd/C Mediated Catalytic Hydrogenations in Pharmaceutical Production
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The practical solutions for scale-up and production of intermediates or precursors of pharmaceuticals by liquid-phase Pd/C mediated hydrogenation can be of considerable interest and deserve broader attention even if they have not been the focus of previously published research due to regulations of patent law. The practical obstacles are persistent and have been known for a long time, but for the most part remained unpublished. The most important discoveries and solutions that contributed to the successful scale-up of hydrogenations for pharmaceutical production were the following: (i) the poisoning of Pd/C catalyst with Fe2+ ions for the selective hydrogenation of 2,6-dimethyl-1-nitrosopiperidine to the corresponding hydrazo compound; (ii) alloying of the deposited Pd metal with Cu for converting the aromatic acid chlorides into the corresponding aldehydes; (iii) alteration of the pH of the reaction mixture to basic values which enhanced the stereoselectivity of paracetamol hydrogenation; (iv) a useful modification of the catalyst preparation process, i.e., the acidification of the catalyst resulted in the hydrogenolysis of benzylic OH in a molecule containing a basic N atom; (v) use of two liquid phases, altogether a four-phase system, which permitted the hydrogenolysis of the S-S bond in a potential catalyst poisoning molecule; (vi) the preservation of the metallic Pd surface of the catalyst by saturation of the reaction mixture with hydrogen, resulting in a high H2/substrate ratio, increased the aldehyde yield in the hydrogenation of 4-chloro-butyric-acid-chloride by avoiding the unwanted poisoning effect of the hydrochloric acid. In the present article, these problems and their solutions, as they emerged during the scale-up of the processes, will be discussed in detail.
- Tungler, Antal,Szabados, Erika
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p. 1246 - 1251
(2016/07/23)
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- Cobalt-bisoxazoline-catalyzed asymmetric kumada cross-coupling of racemic α-bromo esters with aryl grignard reagents
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The first cobalt-catalyzed asymmetric Kumada cross-coupling with high enantioselectivity has been developed. The reaction affords a unique strategy for the enantioselective arylation of α-bromo esters catalyzed by a cobalt-bisoxazoline complex. A variety of chiral α-arylalkanoic esters were prepared in excellent enantioselectivity and yield (up to 97% ee and 96% yield). The arylated products were transformed into α-arylcarboxylic acids and primary alcohols without erosion of ee. The new enantioenriched α-arylpropionic esters synthesized herein are potentially useful in the development of nonsteroidal anti-inflammatory drugs. This method was conducted on gram-scale and applied to the synthesis of highly enantioenriched (S)-fenoprofen and (S)-ar-turmerone.
- Mao, Jianyou,Liu, Feipeng,Wang, Min,Wu, Lin,Zheng, Bing,Liu, Shangzhong,Zhong, Jiangchun,Bian, Qinghua,Walsh, Patrick J.
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supporting information
p. 17662 - 17668
(2015/02/02)
-
- 2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS
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The invention provides certain 2-pyridyl carboxamide-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
- -
-
Paragraph 00243
(2013/04/24)
-
- Synthesis and biological evaluation of novel ferrocene-naphthoquinones as antiplasmodial agents
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This work deals with the synthesis and evaluation of new compounds designed by combination of 1,4-naphthoquinone and ferrocene fragments in a 3-ferrocenylmethyl-2-hydroxy-1,4-naphthoquinone arrangement. A practical coupling reaction between 2-hydroxy-1,4-naphthoquinone and ferrocenemethanol derivatives has been developed. This procedure can be carried out "on-water", at moderate temperatures and without auxiliaries or catalysts, with moderate to high yields. The synthesized derivatives have shown significant in vitro antiplasmodial activity against chloroquine-sensitive and resistant Plasmodium falciparum strains and it has been shown that this activity is not related to the inhibition of biomineralization of ferriprotoporphyrin IX. Binding energy calculations and docking of these compounds to cytochrome b in comparison with atovaquone have been performed.
- García-Barrantes, Pedro M.,Lamoureux, Guy V.,Pérez, Alice L.,García-Sánchez, Rory N.,Martínez, Antonio R.,San Feliciano, Arturo
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p. 548 - 557
(2013/12/04)
-
- Synthesis and radiofluorination of iodophenyl esters as tool for the traceless staudinger ligation
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A new synthetic pathway for the preparation of ω-functionalized 2-iodophenyl esters as starting materials for the synthesis of substituted phosphanes is described. A radiolabeling of these esters with fluorine-18 has led to building blocks which were reacted with HPPh2 in a Pd-catalyzed P-C cross coupling to establish new phosphanes. These compounds can be applied as mild and bioorthogonal radiolabeling agents by means of the traceless Staudinger ligation. A route to access this class of compounds has been established.
- Pretze, Marc,Flemming, Anke,Koeckerling, Martin,Mamata, Constantin
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experimental part
p. 1128 - 1136
(2011/01/09)
-
- Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands
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Piperazinebenzylamine derivatives from trans-4-(4-chlorophenyl)tetrahydrothiophene-3-carboxylic acid 6 and its S-oxide 7 and sulfone 8, and the tetrahydrofuran 9 and its two regioisomers 11 and 13 were synthesized and studied for their binding affinities at the human melanocortin-4 receptor. These five-membered ring constrained compounds possessed similar or lower potency compared to the acyclic analogs.
- Tran, Joe A.,Chen, Caroline W.,Tucci, Fabio C.,Jiang, Wanlong,Fleck, Beth A.,Chen, Chen
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p. 1124 - 1130
(2008/09/18)
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- LIGANDS OF MELANOCORTIN RECEPTORS AND COMPOSITIONS AND METHODS RELATED THERETO
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Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders. The compounds have the following structure (I): (R4)s (R 2)n N~ X1-X2 (CR1aCRlb)q 1~ N R1-lm 1 O R3 (I) including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein m, n, q, s, R1, R1a, R1b, R2, R3, R4, X1 X2 and X3 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
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-
Page/Page column 66
(2010/02/11)
-
- Polymethylene derivatives of nucleic bases with ω-functional groups: V. Pyrimidine- and purine-containing γ-butyrophenones
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New polymethylene derivatives of nucleic bases containing a keto function in the ω-position were synthesized by alkylation of nucleic bases with 2-(3-chloropropyl)-2-phenyl-1,3-dioxolane and the subsequent deblocking of the keto group; their physicochemical properties were studied.
- Kritzyn,Komissarov
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p. 549 - 555
(2007/10/03)
-
- Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic
-
Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein R1 represents hydrogen, OH, alkyl or phenyl alkyl,R2, R3, R4, and R5 represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, andQ represents a group selected from the following groups (i) to (iv), halogen, or alkoxy:
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-
-
- Process for preparing o-(carboalkoxy)phenylmethanesulfonyl chloride derivatives
-
A process for preparing an o-(carboalkoxy)phenylmethanesulfonyl chloride derivative of formula (1), wherein: X is chosen from a hydrogen atom, halogen atoms, C1to C6alkyl groups, C1to C6haloalkyl groups, C1to C6alkoxy groups, C1to C6alkoxycarbonyl groups, a nitro group, and a phenyl group; R is chosen from C1to C6alkyl groups, C1to C6haloalkyl groups, and C3to C6cycloalkyl groups; and n is chosen from integers ranging from 1 to 4, is discussed.
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-
-
- Thiopyridines for use in the control of helicobacter bacteria
-
PCT No. PCT/EP95/02236 Sec. 371 Date Sep. 16, 1997 Sec. 102(e) Date Sep. 16, 1997 PCT Filed Jun. 9, 1995 PCT Pub. No. WO95/34553 PCT Pub. Date Dec. 21, 1995Thiopyridines of formula (I) in which the substituents and symbols are as defined in the specification are suitable for use in controlling Helicobacter bacteria. They are compounded into medicament compositions and administered to subjects afflicted with a disease based on Helicobacter bacteria.
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-
- Preparation of 4,4-dimethoxybutyl chloride from γ-butyrolactone
-
4,4-Dimethoxybutyl chloride 4, an important alternate for the synthesis of 1,5- and 1,6-dicarbonyl functionalities, has been synthesized from γ-butyrolactone.
- Athar, Taimur
-
p. 1037 - 1038
(2007/10/03)
-
- Synthesis of Alkyl and Aryl Cyclopropyl Ketones
-
A series of cyclopropyl ketones are prepared by reactions of organometallic compounds with cyclopropanecarboxylic acid derivatives and also by cyclization of γ-chloro ketones.
- Matveeva,Kvasha,Kurts
-
-
- Stereocontrolled construction of 1, 7-dimethyl A.B.C.[6.6.6] tricycles. Part I. transannular Diels-Alder reactions of 14-membered macrocycles containing frans-dienophiles
-
Transannular Diels-Alder reactions of 14-membered macrocyclic trienes possessing a methyl substituent on both the diene and dienophile moiety have been investigated. Macrocyclic structures la, lb, and lc having cis-trans-trans (CTT), trans-cis-trans (TCT), and trans-trans-trans (TTT) geometries could be stereoselectively constructed by coupling appropriately functionalized dienes 5 and dienophile 4 following an intramolecular displacement of an allylic halide by the anion of an appropriately located dimethyl malonate unit. The transannular Diels-Alder reaction performed on la led to a mixture of four major tricyclic products, including 34 possessing the unexpected trans-anti-cis (TAC) stereochemistry. When heated at 300°C, macrocycle lb underwent an unique conversion via an ene-retroene, Diels-Alder process, producing the unexpected tricycle 41 (racemic form) containing five contiguous chiral centers. A rationale for the above experimental facts is presented. In contrast to the previous results, the transannular Diels-Alder reaction of macrocycle lc was straightforward, producing a 95% isolated yield of trans-anti-cis (TAC) tricycle 34. This investigation demonstrates a general methodology for the stereocontrolled synthesis of 1, 2-dimethyl A.B.C[6.6.6] tricyclic compounds, which are potential precursors to polycyclic natural products such as steroids and terpenes.
- Xu, Yao-Chang,Roughton, Andrew L.,Plante, Raymond,Goldstein, Solo,Deslongchamps, Pierre
-
p. 1152 - 1168
(2007/10/02)
-
- Transannular Diels-Alder reactions on 14-membered macrocyclic trienes. Part I: stereoselective syntheses of the macrocyclic trienes precursors
-
Transannular Diels-Alder reactions on 14-membered macrocycles containing properly located diene and methyl-substituted dienophile units lead to A.B.C. tricycles related to steroids.To study the influence of the olefin and diene geometry on the stereochemical outcome of the Diels-Alder reaction it was necessary to prepare macrocyclic trienes of well-defined stereochemistry.Eight different types of macrocyclic trienes might be obtained by the coupling of appropriate dienophiles and dienes, namely, TTC, TTT, TCC, TCT, CTC, CTT, CCC, and CCT.In this paper (first in a series of two), the synthesis of appropriately functionalized dienophile and diene synthons, as well as their coupling reaction affording macrocyclic triene precursors, is described.
- Ndibwami, Alexis,Lamothe, Serge,Guay, Daniel,Plante, Raymond,Soucy, Pierre,et al.
-
p. 695 - 713
(2007/10/02)
-
- Process for the preparation of chlorides of chlorinated carboxylic acids
-
The invention relates to a process for the preparation of chlorides of chlorinated carboxylic acids of formula STR1 in which R2 denotes the radical (CH2)n, n being an integer from 2 to 4, or the radical --CH2 --C(C6 H5)2 -- and R1 denotes a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms, which consists in reacting the lactones of formula STR2 in which R1 and R2 have the above meanings, with phosgene at a temperature of 90° to 180° C., while employing as catalysts trisubstituted phosphine oxides or sulphides. The process according to the invention makes it possible to obtain chlorides of chlorinated carboxylic acids of high purity which exhibit an excellent stability to light and to heat and which are very useful as synthesis intermediates.
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-
- A New Synthesis of Geranyl Acetate
-
A new route to geranyl acetate starting from isohexenyl chloride (VIII) and 3,4-dichlorobutan-2-one (IX) is described.The route involves stereoselective reactions giving products with the desired configuration.Preparation of VIII by a new method is also described.
- Mathew, K. K.,Raman, P. S.,Antharjanam, T. G. Bhargavi
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p. 340 - 342
(2007/10/02)
-
- SIMPLE PREPARATION OF ω-gem-DISUBSTITUTED HOMOALLYL CHLORIDES
-
The synthesis of the title compounds, starting from γ-butyrolactone, is described.
- Biernacki, Wladyslaw,Gdula, Andrzej
-
p. 849 - 852
(2007/10/02)
-
- Chlorination of Butyryl Chloride in the Liquid Phase
-
The photochlorination of butyryl chloride in the liquid phase at room temperature has been studied.The progress of the chlorination was followed, the mono- and dichloro products being identified and estimated by GLC as their methyl esters.The isomer distribution has been studied in detail at different stages of chlorination.The main compounds identified in the reaction mixture were substrate until 0.5 h, 3-chlorobutyryl chloride between 0.5 and 2.5 h, 3,4-dichlorobutyryl chloride between 2.5 and 7.5 h, 3,3-dichlorobutyryl chloride between 7.5 and 10.0 h and 4,4-dichlorobutyryl chloride after chlorination for 10.0 h.Polychloro compounds were, however, the main products towards the end of the process.
- Korhonen, Ilpo O. O.
-
p. 175 - 178
(2007/10/02)
-
- Interaction of Cyclopropane with Platinum-Metal Chlorides under Carbon Monoxide Pressure in Benzene
-
The six platinum-metal chlorides were reacted with cyclopropane in benzene under carbon monoxide pressure to produce propyl benzenes and, in three instances, chlorobutyrates.The isomer of propylbenzene obtained ranged from pure n-propylbenzene from PdCl2 to pure isopropylbenzene for OsCl3 and IrCl3.The other three platinum-metal chlorides gave mixture of the two propylbenzenes.The reaction was shown to be specific for benzene and cyclopropane as chlorobenzene and toluene failed to enter into the reaction.Likewise, methylcyclopropane did not react with benzene to produce butylbenzenes.
- Johnson, Thomas J.,Baldwin, Thomas F.
-
p. 140 - 142
(2007/10/02)
-
- Antiviral compositions containing bis-basic ketones of thioxanthene
-
The novel bis-basic ketones of thioxanthene have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: SPC1 Wherein A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group EQU1 wherein R1 and R2 are individually hydrogen or lower alkyl having from 1 to about 4 carbon atoms; or B. the group EQU2 WHEREIN N IS A WHOLE INTEGER OF 4 OR 5, AND R3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group EQU3 wherein X is oxygen or NR4, and R4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; or pharmaceutically acceptable acid addition salts of said base. These new compounds can be prepared by several different methods which are described.
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