- New adaptation diseases of cefoperazone medicinal preparation for treating endometritis and other gynecological genital tract infections
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The invention discloses new adaptation diseases of cefoperazone medicinal preparation for treating gynecological genital tract infections of gynecology department. The cefoperazone sodium provided bya specific raw material production process is extremely low in impurity content and remarkable in medicine effect, so that the quality of a preparation product is improved, the safety and effectiveness of the preparation product are guaranteed, and the invention provides the application of preparing the medicine for treating endometritis and other gynecological genital tract infections.
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Paragraph 0108; 0012-0013; 0121-0126; 0143; 0144
(2020/08/22)
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- Cefoperazone sodium compound prepared by using fluid mechanics principle and preparation comprising cefoperazone sodium compound
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The invention discloses a cefoperazone sodium compound prepared by using the fluid mechanics principle. ResearchandDevelopment and Industrialization Project of High-end Medical Product Refinement Crystallization Technologies wins the second prize of national scientific and technological progress in 2015, and the fluid mechanics principle crystallization technology belongs to one of the high-end medical product refinement crystallization technologies. The cefoperazone sodium compound is determined by using X-ray powder diffraction, and the main characteristic peaks represented by the diffraction angle 2 theta in a map are located at 10.25+/-0.2 degrees, 14.40+/-0.2 degrees, 18.51+/-0.2 degrees, 23.14+/-0.2 degrees, 29.10+/-0.2 degrees, 33.25+/-0.2 degrees and 38.45+/-0.2 degrees. Cefoperazone acid reacts with a salt forming agent, and the cefoperazone sodium compound is prepared through secondary crystallization. The operation is simple, reactants are easy to obtain, the reaction condition is mild, and the yield is high. The compound is high in purity, low in impurity content, good in fluidity and good in stability. Meanwhile, the invention further discloses a preparation prepared from cefoperazone sodium, namely, cefoperazone sodium for injection. The preparation process of the preparation is simple, no excipient is needed, and the preparation has better stability and few side effects.
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Paragraph 0025; 0026; 0037; 0038; 0039-0044; 0054-0057
(2017/05/12)
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- Cefoperazone sodium compound and sulbactam sodium compound prepared with strong-field coupling crystallization technology as well as prepared composition
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The invention discloses a cefoperazone sodium compound and a sulbactam sodium compound. The cefoperazone sodium compound and the sulbactam sodium compound are both prepared with a strong-field coupling crystallization technology, specifically, ultrasonic out-field strengthened crystals are added in the compound crystallization process, and the high-purity compounds are prepared. 'Research & Development of the Industrialization Project of High-end Medicine Product Refining Crystallization Technologies' wins the 2015 national scientific and technological progress second prize, and the high-field coupling crystallization technology belongs to one of high-end medicine product refining crystallization technologies. The two compounds have the characteristics of high purity and good stability. Besides, the invention further discloses cefoperazone sodium and sulbactam sodium medicinal composition. The cefoperazone sodium and sulbactam sodium medicinal composition is prepared from components in parts by weight as follows: 0.25-2 parts of cefoperazone sodium (on the basis of C25H27N9O8S2) and 0.25-2 parts of sulbactam sodium (on the basis of C8H11NO5S).
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Paragraph 0042-0045; 0046; 0047; 0048-0051; 0071-0075
(2017/06/21)
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- A NEW CRYSTAL FORM OF CEFOPERAZONE SODIUM
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The present invention relates to a new crystal form of cefoperazone sodium and the method for making said crystal form. The new crystal form has the following characteristics: orthorhombic crystal, space group F222, unit cell dimensions a=52.15?, b=51.87? and c=4.95 ?.
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Page/Page column 6; 7
(2014/02/15)
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- Process for the preparation of highly crystalline sodium cefoperazone
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Highly crystalline, highly filterable sodium Cefoperazone in the form of needle crystal aggregates, obtainable by a process comprising the controlled addition of acetone to a solution of water/acetone/alcohols/sodium Cefoperazone at 20?40° C.
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