62893-20-3 Usage
Uses
Used in Pharmaceutical Industry:
Cefoperazone sodium is used as an antibacterial agent for the treatment of a wide range of bacterial infections. Its broad-spectrum activity makes it a valuable tool in the fight against antibiotic-resistant bacteria.
Used in Antidepressant Applications:
Cefoperazone sodium is also used as an antidepressant, specifically as a serotonin reuptake inhibitor and a 5HT1A agonist. This application highlights its versatility in the medical field, as it can address both bacterial infections and mental health conditions.
Used in Research and Development:
In the field of research, Cefoperazone sodium is utilized for studying the expression, binding, and inhibition of penicillin-binding proteins. This helps in understanding the mechanisms of drug-protein interactions and the development of new antibiotics.
Used in Prevention of Postoperative Infections:
Cefoperazone sodium is used as an antimicrobial agent to prevent infections that may occur after surgery. Its effectiveness in combating bacteria makes it a crucial component in postoperative care.
Used in Inhibition of Alfa-Antitrypsin Inactivation:
Cefoperazone sodium is employed as an inhibitor of the inactivation of alfa-antitrypsin, a protein that protects the lungs from damage caused by an excessive number of neutrophils. This application further demonstrates its importance in various medical and therapeutic areas.
Therapeutic Function
Antibiotic
Biological Activity
cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as escherichia coli, klebsiella pneumoniae, and proteus species [1].
Clinical Use
Cefoperazone sodium is a third-generation, antipseudomonalcephalosporin that resembles piperacillinchemically and microbiologically. It is active against manystrains of P. aeruginosa, indole-positive Proteus spp.,Enterobacter spp., and S. marcescens that are resistant tocefamandole. It is less active than cephalothin againstGram-positive bacteria and less active than cefamandoleagainst most of the Enterobacteriaceae. Like piperacillin,cefoperazone is hydrolyzed by many of the β-lactamasesthat hydrolyze penicillins. Unlike piperacillin, however, itis resistant to some (but not all) of the β-lactamases thathydrolyze cephalosporins.Cefoperazone is excreted primarily in the bile. Hepaticdysfunction can affect its clearance from the body.
Veterinary Drugs and Treatments
Cefoperazone is used to treat serious infections, particularly susceptible
Enterobacteriaceae not susceptible to other less expensive
agents or when aminoglycosides are not indicated (due to their potential
toxicity).
in vitro
there was only a small spread between the minimum inhibitory concentrations and the minimum bactericidal concentrations of cefoperazone and a significant decrease in activity with an increase in inoculum size. cefoperazone is relatively stable to hydrolysis to β-lactamases produced by gram-negative bacteria. relative rates of hydrolysis of cefoperazone by cephalosporinases were 7.0 to 0.01[1]. in 50 strains of n. gonorrhoeae, the mic50 of cefoperazone was ≤ 0.004-0.06 μg/ml [2].
in vivo
in four patients with cholelithiasis and one patient with carcinoma of the head of the pancreas, all of whom had normal renal functions, cefoperazone was intravenously administrated. in common duct bile, the maximum concentrations of cefoperazone ranged from 373.4 to 3,100 μg/ml while the concentrations ranged from 6.8 to 680 μg/ml in gall bladder bile. cefoperazone concentrations of the gall bladder wall ranged from 16.8 to 48.0 μg/g [3].
references
[1] matsubara n, minami s, muraoka t, et al. in vitro antibacterial activity of cefoperazone (t-1551), a new semisynthetic cephalosporin[j]. antimicrobial agents and chemotherapy, 1979, 16(6): 731-735.[2] baker c n, thornsberry c, jones r n. in vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (ly127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against neisseria gonorrhoeae and haemophilus influenzae, including beta-lactamase-producing strains[j]. antimicrobial agents and chemotherapy, 1980, 17(4): 757-761.[3] nakamura t, hashimoto i, sawada y, et al. cefoperazone concentrations in bile and gall bladder wall after intravenous administration[j]. antimicrobial agents and chemotherapy, 1980, 18(6): 980-982.
Check Digit Verification of cas no
The CAS Registry Mumber 62893-20-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,8,9 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 62893-20:
(7*6)+(6*2)+(5*8)+(4*9)+(3*3)+(2*2)+(1*0)=143
143 % 10 = 3
So 62893-20-3 is a valid CAS Registry Number.
InChI:InChI=1/C25H27N9O8S2.Na/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);/q;+1/p-1/t15-,16-,22-;/m1./s1
62893-20-3Relevant articles and documents
New adaptation diseases of cefoperazone medicinal preparation for treating endometritis and other gynecological genital tract infections
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, (2020/08/22)
The invention discloses new adaptation diseases of cefoperazone medicinal preparation for treating gynecological genital tract infections of gynecology department. The cefoperazone sodium provided bya specific raw material production process is extremely low in impurity content and remarkable in medicine effect, so that the quality of a preparation product is improved, the safety and effectiveness of the preparation product are guaranteed, and the invention provides the application of preparing the medicine for treating endometritis and other gynecological genital tract infections.
Cefoperazone sodium compound prepared by using fluid mechanics principle and preparation comprising cefoperazone sodium compound
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Paragraph 0025; 0026; 0037; 0038; 0039-0044; 0054-0057, (2017/05/12)
The invention discloses a cefoperazone sodium compound prepared by using the fluid mechanics principle. ResearchandDevelopment and Industrialization Project of High-end Medical Product Refinement Crystallization Technologies wins the second prize of national scientific and technological progress in 2015, and the fluid mechanics principle crystallization technology belongs to one of the high-end medical product refinement crystallization technologies. The cefoperazone sodium compound is determined by using X-ray powder diffraction, and the main characteristic peaks represented by the diffraction angle 2 theta in a map are located at 10.25+/-0.2 degrees, 14.40+/-0.2 degrees, 18.51+/-0.2 degrees, 23.14+/-0.2 degrees, 29.10+/-0.2 degrees, 33.25+/-0.2 degrees and 38.45+/-0.2 degrees. Cefoperazone acid reacts with a salt forming agent, and the cefoperazone sodium compound is prepared through secondary crystallization. The operation is simple, reactants are easy to obtain, the reaction condition is mild, and the yield is high. The compound is high in purity, low in impurity content, good in fluidity and good in stability. Meanwhile, the invention further discloses a preparation prepared from cefoperazone sodium, namely, cefoperazone sodium for injection. The preparation process of the preparation is simple, no excipient is needed, and the preparation has better stability and few side effects.
Cefoperazone sodium compound and sulbactam sodium compound prepared with strong-field coupling crystallization technology as well as prepared composition
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Paragraph 0042-0045; 0046; 0047; 0048-0051; 0071-0075, (2017/06/21)
The invention discloses a cefoperazone sodium compound and a sulbactam sodium compound. The cefoperazone sodium compound and the sulbactam sodium compound are both prepared with a strong-field coupling crystallization technology, specifically, ultrasonic out-field strengthened crystals are added in the compound crystallization process, and the high-purity compounds are prepared. 'Research & Development of the Industrialization Project of High-end Medicine Product Refining Crystallization Technologies' wins the 2015 national scientific and technological progress second prize, and the high-field coupling crystallization technology belongs to one of high-end medicine product refining crystallization technologies. The two compounds have the characteristics of high purity and good stability. Besides, the invention further discloses cefoperazone sodium and sulbactam sodium medicinal composition. The cefoperazone sodium and sulbactam sodium medicinal composition is prepared from components in parts by weight as follows: 0.25-2 parts of cefoperazone sodium (on the basis of C25H27N9O8S2) and 0.25-2 parts of sulbactam sodium (on the basis of C8H11NO5S).
A NEW CRYSTAL FORM OF CEFOPERAZONE SODIUM
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Page/Page column 6; 7, (2014/02/15)
The present invention relates to a new crystal form of cefoperazone sodium and the method for making said crystal form. The new crystal form has the following characteristics: orthorhombic crystal, space group F222, unit cell dimensions a=52.15?, b=51.87? and c=4.95 ?.
Process for the preparation of highly crystalline sodium cefoperazone
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, (2008/06/13)
Highly crystalline, highly filterable sodium Cefoperazone in the form of needle crystal aggregates, obtainable by a process comprising the controlled addition of acetone to a solution of water/acetone/alcohols/sodium Cefoperazone at 20?40° C.
