A novel and efficient lewis acid catalysed preparation of pyrimidines: Microwave-promoted reaction of urea and β-formyl enamides
A novel and efficient synthesis of pyrimidine from β-formyl enamide is described. The key step involves samarium chloride catalysed cyclisation of β-formyl enamides using urea as source of ammonia under microwave irradiation. Georg Thieme Verlag Stuttgart