A different role of Meldrum's acid in the Biginelli reaction
A Biginelli-type condensation using Meldrum's acid has been accomplished in refluxing AcOH to give 6-substituted dihydropyrimidine-2,4-(1H,3H)-diones. In contrast to other aldehydes, the three-component reaction with salicylaldehyde led to an oxygen-bridged pyridine. A reaction mechanism is proposed.
Svetlik, Jan,Veizerova, Lucia
experimental part
p. 199 - 205
(2011/04/17)
Search for potential antineoplastic agents. Possible formation of hydrogenated pyrimidine derivatives from coumarin derivatives
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Wachi,Takagi,Menichi,Hubert-Habart
p. 230 - 233
(2007/10/08)
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