Copper-catalyzed guanidinylation of aryl iodides: The formation of N,N′-disubstituted guanidines
Chemical Equation Presented A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N′-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/1 igand system provided a simple diarylation procedure.
Cortes-Salva, Michelle,Nguyen, Be-Lan,Cuevas, Javier,Pennypacker, Keith R.,Antilla, Jon C.
supporting information; experimental part
p. 1316 - 1319
(2010/06/15)
Synthetic routes to N-Pmc-N′,N″-disubstituted guanidines via EDCI-mediated guanylation of amines with N-Pmc-N′-substituted thioureas
An overview of the facile and high-yielding EDCI-mediated reaction of amines with N-Pmc-N′-alkyl thioureas to afford guanidines is presented, in which the general scope and limitations of the reaction are probed. It was found that the N-sulfonyl-N′-substi
Flemer Jr., Stevenson,Madalengoitia, Jose S.
p. 1848 - 1860
(2008/02/10)
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