632294-01-0

Basic information

• Product Name: N-benzhydrylthiophene-2-sulfonamide
• Synonyms: N-benzhydrylthiophene-2-sulfonamide
• CAS NO: 632294-01-0
• Molecular Weight: 329.444
• Mol File: 632294-01-0.mol

Chemical Properties

• CAS DataBase Reference: N-benzhydrylthiophene-2-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzhydrylthiophene-2-sulfonamide(632294-01-0)
• EPA Substance Registry System: N-benzhydrylthiophene-2-sulfonamide(632294-01-0)

Safety Data

• Hazardous Substances Data: 632294-01-0(Hazardous Substances Data)

Upstream product

• 382-99-0 thiophene-2-sulfonyl fluoride 
• 91-00-9 Benzhydrylamine 
• 308293-22-3 N-phenylmethylene 2-thiophenesulfonamide 
• 591-50-4 iodobenzene 
• 108-90-7 chlorobenzene 
• 6339-87-3 2-thiophensulfonamide 
• 91-01-0 1,1-Diphenylmethanol 
• 16629-19-9 thiophene-2-sulfonyl chloride 

Relevant articles and documents

A Broad-Spectrum Catalytic Amidation of Sulfonyl Fluorides and Fluorosulfates**

A broad-spectrum, catalytic method has been developed for the synthesis of sulfonamides and sulfamates. With the activation by the combination of a catalytic amount of 1-hydroxybenzotriazole (HOBt) and silicon additives, amidations of sulfonyl fluorides and fluorosulfates proceeded smoothly and excellent yields were generally obtained (87–99 %). Noticeably, this protocol is particularly efficient for sterically hindered substrates. Catalyst loading is generally low and only 0.02 mol % of catalyst is required for the multidecagram-scale synthesis of an amantadine derivative. In addition, the potential of this method in medicinal chemistry has been demonstrated by the synthesis of the marketed drug Fedratinib via a key intermediate sulfonyl fluoride 13. Since a large number of amines are commercially available, this route provides a facile entry to access Fedratinib analogues for biological screening.

CoI-Catalyzed Barbier Reactions of Aromatic Halides with Aromatic Aldehydes and Imines

The reductive Barbier coupling of aromatic halides and electrophiles has been achieved using a CoBr2/1,10-phenanthroline catalytic system and over stoichiometric amounts of zinc. The reaction displayed a broad scope of substrates, including (hetero)aryl chlorides as pro-nucleophiles and aldehydes or imines as electrophiles, leading to diarylmethanols and diarylmethylamines in moderate to excellent yields, respectively.

Aluminum triflate as a powerful catalyst for direct amination of alcohols, including electron-withdrawing group-substituted benzhydrols

Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron-withdrawing (F, Br, I, NO2, or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf)3] to afford the corresponding biarylamines in high yield, and the dibromo-substituted product was further transformed into letrozole. Copyright

Catalytic coupling of N-benzylic sulfonamides with silylated nucleophiles at room temperature

In the presence of 2-10 mol% of Tf2NH, a range of N-benzylic sulfonamides smoothly react with allylic, propargylic, benzylic, or hydrido silanes at room temperature via sp3 carbon-nitrogen bond cleavage to afford structurally diverse products in moderate to excellent yields and with high chemo- and regioselectivity.