632335-63-8Relevant articles and documents
New stereoselective synthesis of 2-allyl-4-nitroalkylpiperidine-2-thiones and their transformation to annulated piperidinones
So?nicki, Jacek G.
, p. 1673 - 1677 (2003)
Highly stereocontrolled access to trans-3-allyl-4nitro-alkyl-1,6-disubstituted δ-thiolactams was achieved starting from piperidine-2-thione or commercially available 2-mercaptopyridine via Michael-addition of nitroalkanes to 5,6-dihydropyridin-2-thiones, S-allylation and thio-Claisen rearrangement. The corresponding lactams obtained by desulfurisation, were found to be suitable precursors for the construction of trans-fused bicyclic 2-piperidinone derivatives (octahydro[2]pyrindinones) in a regio- and stereoselective radical 5-exo-trig annulation process.
An easy approach to α,β-unsaturated δ-thiolactams via a RCM and thionation one-pot procedure
So?nicki, Jacek G.
supporting information; experimental part, p. 178 - 181 (2009/05/07)
An easy approach to mono- and bicyclic derivatives of 5,6-dihydro-1H-pyridine-2-thione via a one-pot ring closing metathesis (RCM) of dialkenoic amides and thionation using Lawesson's reagent, followed by isomerization of the 3,6-dihydro-isomer (if necess